Similarity-index early seizure detector VLSI architecture

A low power VLSI architecture implementing an algorithm for early seizure detection in epileptic patients using intracranial or scalp EEG data is proposed. The algorithm tested over more than 40 hours of recording from standard databases achieves a best-case result of 100% sensitivity at a false positive rate of 0.2 per hour. The algorithm is programmed on an FPGA and was experimentally validated along with a neural recording SoC chip to demonstrate a real-time seizure detection microsystem.

[1]  Jeffrey M. Hausdorff,et al.  Physionet: Components of a New Research Resource for Complex Physiologic Signals". Circu-lation Vol , 2000 .

[2]  J. Martinerie,et al.  Anticipating epileptic seizures in real time by a non-linear analysis of similarity between EEG recordings. , 1999, Neuroreport.

[3]  Gabriel Lang,et al.  Quadratic variations and estimation of the local Hölder index of a gaussian process , 1997 .

[4]  Murad S. Taqqu,et al.  Semi-parametric estimation of the long-range dependence parameter : A survey , 2003 .

[5]  Karim Abdelhalim,et al.  915-MHz wireless 64-channel neural recording SoC with programmable mixed-signal FIR filters , 2011, 2011 Proceedings of the ESSCIRC (ESSCIRC).

[6]  J. Martinerie,et al.  Comparison of Hilbert transform and wavelet methods for the analysis of neuronal synchrony , 2001, Journal of Neuroscience Methods.

[7]  Pedram Mohseni,et al.  A Battery-Powered Activity-Dependent Intracortical Microstimulation IC for Brain-Machine-Brain Interface , 2011, IEEE Journal of Solid-State Circuits.

[8]  Zhiguo Wang,et al.  Estimating Hurst exponent with wavelet packet , 2006, 2006 7th International Conference on Computer-Aided Industrial Design and Conceptual Design.

[9]  Evgenia Sitnikova,et al.  Granger causality: Cortico-thalamic interdependencies during absence seizures in WAG/Rij rats , 2008, Journal of Neuroscience Methods.

[10]  E. H. Lloyd,et al.  Long-Term Storage: An Experimental Study. , 1966 .

[11]  Steve S. Chung,et al.  Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy , 2010, Epilepsia.

[12]  Felice T. Sun,et al.  Responsive cortical stimulation for the treatment of epilepsy , 2011, Neurotherapeutics.

[13]  Karim Abdelhalim,et al.  A phase synchronization and magnitude processor VLSI architecture for adaptive neural stimulation , 2010, 2010 Biomedical Circuits and Systems Conference (BioCAS).