Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants

Drinking water contamination with poly- and perfluoroalkyl substances (PFASs) poses risks to the developmental, immune, metabolic, and endocrine health of consumers. We present a spatial analysis of 2013-2015 national drinking water PFAS concentrations from the U.S. Environmental Protection Agency's (US EPA) third Unregulated Contaminant Monitoring Rule (UCMR3) program. The number of industrial sites that manufacture or use these compounds, the number of military fire training areas, and the number of wastewater treatment plants are all significant predictors of PFAS detection frequencies and concentrations in public water supplies. Among samples with detectable PFAS levels, each additional military site within a watershed's eight-digit hydrologic unit is associated with a 20% increase in PFHxS, a 10% increase in both PFHpA and PFOA, and a 35% increase in PFOS. The number of civilian airports with personnel trained in the use of aqueous film-forming foams is significantly associated with the detection of PFASs above the minimal reporting level. We find drinking water supplies for 6 million U.S. residents exceed US EPA's lifetime health advisory (70 ng/L) for PFOS and PFOA. Lower analytical reporting limits and additional sampling of smaller utilities serving <10000 individuals and private wells would greatly assist in further identifying PFAS contamination sources.

[1]  Tony Fletcher,et al.  Private Drinking Water Wells as a Source of Exposure to Perfluorooctanoic Acid (PFOA) in Communities Surrounding a Fluoropolymer Production Facility , 2010, Environmental health perspectives.

[2]  Steven H Strauss,et al.  Method for the determination of sub-ppm concentrations of perfluoroalkylsulfonate anions in water. , 2002, Journal of environmental monitoring : JEM.

[3]  WORKING TOWARDS A GLOBAL EMISSION INVENTORY OF PFASS: FOCUS ON PFCAS - STATUS QUO AND THE WAY FORWARD WORKING TOWARDS A GLOBAL EMISSION INVENTORY OF PFASS: FOCUS ON PFCAS - STATUS QUO AND THE WAY FORWARD , 2015 .

[4]  Youngihn Kho,et al.  GeoDa: An Introduction to Spatial Data Analysis , 2006 .

[5]  L. Buxton,et al.  Evaluation of chronic toxicity and carcinogenicity of ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate in Sprague–Dawley rats , 2015, Toxicology reports.

[6]  Nancy L. Barber,et al.  Estimated use of water in the United States in 2010 , 2014 .

[7]  Anna Palm Cousins,et al.  Stockholm Arlanda Airport as a source of per- and polyfluoroalkyl substances to water, sediment and fish. , 2015, Chemosphere.

[8]  H. Koivusalo,et al.  Contamination risk of raw drinking water caused by PFOA sources along a river reach in south-western Finland. , 2016, The Science of the total environment.

[9]  Esben Budtz-Jørgensen,et al.  Serum vaccine antibody concentrations in children exposed to perfluorinated compounds. , 2012, JAMA.

[10]  E. Kissa,et al.  Fluorinated Surfactants and Repellents , 2001 .

[11]  Allan N. Williams,et al.  Biomonitoring for perfluorochemicals in a Minnesota community with known drinking water contamination. , 2014, Journal of environmental health.

[12]  L. Birnbaum,et al.  Alternatives to PFASs: Perspectives on the Science , 2015, Environmental health perspectives.

[13]  H. Anton-Culver,et al.  Preliminary Associations between the Detection of Perfluoroalkyl Acids (PFAAs) in Drinking Water and Serum Concentrations in a Sample of California Women , 2016 .

[14]  J. Meeker,et al.  Serum Biomarkers of Exposure to Perfluoroalkyl Substances in Relation to Serum Testosterone and Measures of Thyroid Function among Adults and Adolescents from NHANES 2011–2012 , 2015, International journal of environmental research and public health.

[15]  S. Nakayama,et al.  Application of WWTP biosolids and resulting perfluorinated compound contamination of surface and well water in Decatur, Alabama, USA. , 2011, Environmental science & technology.

[16]  Ian T Cousins,et al.  Tracking the pathways of human exposure to perfluorocarboxylates. , 2009, Environmental science & technology.

[17]  A REVIEW OF STATEWIDE WATERSHED MANAGEMENT APPROACHES FINAL REPORT APRIL 2002 U. S. ENVIRONMENTAL PROTECTION AGENCY OFFICE OF WATER , 2002 .

[18]  M. Clara,et al.  Emissions of perfluorinated alkylated substances (PFAS) from point sources--identification of relevant branches. , 2008, Water science and technology : a journal of the International Association on Water Pollution Research.

[19]  Jack Thompson,et al.  Concentrations of PFOS, PFOA and other perfluorinated alkyl acids in Australian drinking water. , 2011, Chemosphere.

[20]  Lakhwinder S Hundal,et al.  Occurrence and fate of perfluorochemicals in soil following the land application of municipal biosolids. , 2011, Environmental science & technology.

[21]  C. D. de Wit,et al.  What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review protocol , 2015, Environmental Evidence.

[22]  H. Akaike.  A new look at the statistical model identification , 1974 .

[23]  Gloria B Post,et al.  Perfluorooctanoic acid (PFOA), an emerging drinking water contaminant: a critical review of recent literature. , 2012, Environmental research.

[24]  D. Sedlak,et al.  Persistence of perfluoroalkyl acid precursors in AFFF-impacted groundwater and soil. , 2013, Environmental science & technology.

[25]  R. G. York,et al.  Evaluation of potential reproductive and developmental toxicity of potassium perfluorohexanesulfonate in Sprague Dawley rats. , 2009, Reproductive toxicology.

[26]  June-Soo Park,et al.  Poly- and perfluoroalkyl substances in wastewater: Significance of unknown precursors, manufacturing shifts, and likely AFFF impacts. , 2016, Water research.

[27]  M. Dam,et al.  Perfluoroalkyl substances (PFASs) in food and water from Faroe Islands , 2013, Environmental Science and Pollution Research.

[28]  G. Viviano,et al.  Occurrence and sources of perfluoroalkyl acids in Italian river basins. , 2015, Chemosphere.

[29]  Andrea C. Blaine,et al.  Bioaccumulation of perfluoroalkyl acids by earthworms (Eisenia fetida) exposed to contaminated soils. , 2015, Environmental science & technology.

[30]  E. Budtz-Jørgensen,et al.  Immunotoxicity of perfluorinated alkylates: calculation of benchmark doses based on serum concentrations in children , 2013, Environmental Health.

[31]  J. Peterson,et al.  Concentrations and patterns of perfluoroalkyl acids in Georgia, USA surface waters near and distant to a major use source , 2008, Environmental toxicology and chemistry.

[32]  S. Bergström.  Transport of per- and polyfluoroalkyl substances in soil and groundwater in Uppsala, Sweden , 2014 .

[33]  A. Calafat,et al.  Prenatal Perfluoroalkyl Substance Exposure and Child Adiposity at 8 Years of Age: The HOME Study , 2015, Obesity.

[34]  Ruthann A Rudel,et al.  Pharmaceuticals, perfluorosurfactants, and other organic wastewater compounds in public drinking water wells in a shallow sand and gravel aquifer. , 2014, The Science of the total environment.

[35]  K. Kannan,et al.  Inter-laboratory trials for analysis of perfluorooctanesulfonate and perfluorooctanoate in water samples: performance and recommendations. , 2013, Analytica chimica acta.

[36]  James Franklin,et al.  Perfluoroalkyl and Polyfluoroalkyl Substances in the Environment: Terminology, Classification, and Origins , 2011, Integrated environmental assessment and management.

[37]  R. Anderson,et al.  Occurrence of select perfluoroalkyl substances at U.S. Air Force aqueous film-forming foam release sites other than fire-training areas: Field-validation of critical fate and transport properties. , 2016, Chemosphere.

[38]  Elsie M. Sunderland,et al.  Draft Guidance on the Development, Evaluation, and Application of Regulatory Environmental Models , 2003 .

[39]  Kurunthachalam Kannan,et al.  Perfluoroalkyl sulfonates and perfluorocarboxylates in two wastewater treatment facilities in Kentucky and Georgia. , 2007, Water research.

[40]  Jennifer A Field,et al.  Fluorochemical mass flows in a municipal wastewater treatment facility. , 2006, Environmental science & technology.

[41]  Jan Busch,et al.  Polyfluoroalkyl compounds in landfill leachates. , 2010, Environmental pollution.

[42]  Pim de Voogt,et al.  Perfluorinated substances in human food and other sources of human exposure. , 2010, Reviews of environmental contamination and toxicology.

[43]  Andrea C. Blaine,et al.  Uptake of perfluoroalkyl acids into edible crops via land applied biosolids: field and greenhouse studies. , 2013, Environmental science & technology.

[44]  Jennifer A Field,et al.  Occurrence and persistence of perfluorooctanesulfonate and other perfluorinated surfactants in groundwater at a fire-training area at Wurtsmith Air Force Base, Michigan, USA. , 2003, Journal of environmental monitoring : JEM.

[45]  K. Steenland,et al.  Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers among Adults Living Near a Chemical Plant , 2013, Environmental health perspectives.

[46]  B. Sanders,et al.  Environmental fate and transport modeling for perfluorooctanoic acid emitted from the Washington Works Facility in West Virginia. , 2011, Environmental science & technology.

[47]  Martin Kraft,et al.  Biomonitoring of Perfluorinated Compounds in Children and Adults Exposed to Perfluorooctanoate-Contaminated Drinking Water , 2008, Environmental health perspectives.

[48]  S. Sauvé,et al.  Quantitative analysis of poly- and perfluoroalkyl compounds in water matrices using high resolution mass spectrometry: optimization for a laser diode thermal desorption method. , 2015, Analytica chimica acta.

[49]  K. Hungerbühler,et al.  Global emission inventories for C4-C14 perfluoroalkyl carboxylic acid (PFCA) homologues from 1951 to 2030, Part I: production and emissions from quantifiable sources. , 2014, Environment international.

[50]  L. Shaw,et al.  Community Exposure to Perfluorooctanoate: Relationships Between Serum Concentrations and Exposure Sources , 2006, Journal of occupational and environmental medicine.

[51]  Kurunthachalam Kannan,et al.  Mass loading and fate of perfluoroalkyl surfactants in wastewater treatment plants. , 2006, Environmental science & technology.

[52]  Morton A Barlaz,et al.  Quantitative determination of fluorochemicals in municipal landfill leachates. , 2011, Chemosphere.