Critical oxygen tension at the corneal surface.

Human corneas in vivo were exposed to a reduced partial pressure of atmospheric oxygen in order to determine the minimum oxygen for normal corneal hydration. Below a critical range of 11 to 19 mm Hg, the cornea will hydrate and swell. The rate of swelling increases as the oxygen tension decreases. The oxygen required by the epithelium is about one tenth of that available from the atmosphere when the eyes are open and about one fourth of that available from the palpebral conjunctiva when the eyes are closed.

[1]  R. Hill,et al.  Oxygen Uptake from a Reservoir of Limited Volume by the Human Cornea in vivo , 1963, Science.

[2]  M. Langham.  Utilization of oxygen by the component layers of the living cornea , 1952, The Journal of physiology.

[3]  I. Fatt,et al.  THE DIFFUSION OF OXYGEN IN THE CORNEA. , 1965, Experimental eye research.

[4]  G. K. Smelser.  Relation of factors involved in maintenance of optical properties of cornea to contact-lens wear. , 1952, A.M.A. archives of ophthalmology.

[5]  G. K. Smelser,et al.  Physiological Changes in Cornea orneu induced by Contact Lenses , 1955 .

[6]  R. Mandell,et al.  Corneal swelling caused by contact lens wear. , 1970, Archives of ophthalmology.

[7]  R. Mandell,et al.  Keratoconus: spatial variation of corneal thickenss as a diagnostic test. , 1969, Archives of ophthalmology.

[8]  R. Farris,et al.  Oxygen flux across the in vivo rabbit cornea. , 1965, Archives of ophthalmology.

[9]  J. E. Harris.  The physiologic control of corneal hydration. , 1957, American journal of ophthalmology.

[10]  I. Fatt,et al.  The steady-state distribution of oxygen and carbon dioxide in the in vivo cornea. I. The open eye in air and the closed eye. , 1968, Experimental eye research.

[11]  R. Hill,et al.  OXYGEN REQUIREMENTS OF CONTACT LENS SYSTEMS* I. COMPARISON OF MATHEMATICAL PREDICTIONS WITH PHYSIOLOGICAL MEASUREMENTS , 1969, American journal of optometry and archives of American Academy of Optometry.

[12]  R. Mandell,et al.  Thinning of the Human Cornea on Awakening , 1965, Nature.

[13]  G. K. Smelser,et al.  Structural changes in corneas of guinea pigs after wearing contact lenses. , 1953, A.M.A. archives of ophthalmology.

[14]  R. Hill,et al.  OXYGEN DEPRIVATION OF THE CORNEA BY CONTACT LENSES AND LID CLOSURE. , 1964, American journal of optometry and archives of American Academy of Optometry.

[15]  M. Langham,et al.  Permeability of the Cornea and the Blood-Aqueous Barrier to Oxygen * , 1956, The British journal of ophthalmology.

[16]  S. Mishima,et al.  The thickness-hydration relationship of the cornea. , 1966, Experimental eye research.

[17]  G. K. Smelser,et al.  Importance of atmospheric oxygen for maintenance of the optical properties of the human cornea. , 1952, Science.

[18]  L. Horberg.  Quaternary Volcanic Ash in Southern Alberta, Canada. , 1952, Science.

[19]  J. E. Harris,et al.  The hydration of the cornea. I. The transport of water from the cornea. , 1956, American journal of ophthalmology.

[20]  I Fatt,et al.  OXYGEN TENSION UNDER A CONTACT LENS DURING BLINKING* , 1969, American journal of optometry and archives of American Academy of Optometry.