Advances in hydrogel delivery systems for tissue regeneration.

Hydrogels are natural or synthetic polymer networks that have high water-absorbing capacity and closely mimic native extracellular matrices. As hydrogel-based cell delivery systems are being increasingly employed in regenerative medicine, several advances have been made in the hydrogel chemistry and modification for enhanced control of cell fate and functions, and modulation of cell and tissue responses against oxidative stress and inflammation in the tissue environment. This review aims to provide the state-of-the-art overview of the recent advances in field, discusses new perspectives and challenges in the regeneration of specific tissues, and highlights some of the limitations of current systems for possible future advancements.

[1]  Milica Radisic,et al.  Controlled release of thymosin β4 using collagen-chitosan composite hydrogels promotes epicardial cell migration and angiogenesis. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[2]  J. Ringe,et al.  Chitosan‐based injectable hydrogel as a promising in situ forming scaffold for cartilage tissue engineering , 2014, Cell biology international.

[3]  A. Wan,et al.  Modulation of chondrocyte functions and stiffness-dependent cartilage repair using an injectable enzymatically crosslinked hydrogel with tunable mechanical properties. , 2014, Biomaterials.

[4]  Changyong Wang,et al.  A chitosan-glutathione based injectable hydrogel for suppression of oxidative stress damage in cardiomyocytes. , 2013, Biomaterials.

[5]  Y. Pek,et al.  The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid-tyramine composite as an injectable bone cement. , 2009, Biomaterials.

[6]  K. Christman,et al.  Myocardial matrix–polyethylene glycol hybrid hydrogels for tissue engineering , 2014, Nanotechnology.

[7]  Teck Chuan Lim,et al.  The effect of injectable gelatin-hydroxyphenylpropionic acid hydrogel matrices on the proliferation, migration, differentiation and oxidative stress resistance of adult neural stem cells. , 2012, Biomaterials.

[8]  Yuan Ji,et al.  Dual-syringe reactive electrospinning of cross-linked hyaluronic acid hydrogel nanofibers for tissue engineering applications. , 2006, Macromolecular bioscience.

[9]  Daniel J. Macaya,et al.  Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury. , 2013, Biomaterials.

[10]  Robert Langer,et al.  Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells , 2007, Proceedings of the National Academy of Sciences.

[11]  M. Spector,et al.  Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilage. , 2011, Molecular pharmaceutics.

[12]  Ping Zhu,et al.  Preparation and characterization of IPN hydrogels composed of chitosan and gelatin cross-linked by genipin. , 2014, Carbohydrate polymers.

[13]  S. Sia,et al.  Engineering extracellular matrix structure in 3D multiphase tissues. , 2011, Biomaterials.

[14]  Daniel J. Macaya,et al.  Injectable Collagen–Genipin Gel for the Treatment of Spinal Cord Injury: In Vitro Studies , 2011 .

[15]  M. Prabhakaran,et al.  Mechanical properties and in vitro behavior of nanofiber–hydrogel composites for tissue engineering applications , 2012, Nanotechnology.

[16]  M. Longaker,et al.  Pullulan hydrogels improve mesenchymal stem cell delivery into high-oxidative-stress wounds. , 2011, Macromolecular bioscience.

[17]  Ali Khademhosseini,et al.  Directed endothelial cell morphogenesis in micropatterned gelatin methacrylate hydrogels. , 2012, Biomaterials.

[18]  Qia Zhang,et al.  Peripheral nerve repair in rats using composite hydrogel-filled aligned nanofiber conduits with incorporated nerve growth factor. , 2013, Tissue engineering. Part A.

[19]  Jiang Chang,et al.  Bioglass/alginate composite hydrogel beads as cell carriers for bone regeneration. , 2014, Journal of biomedical materials research. Part B, Applied biomaterials.

[20]  Jackie Y Ying,et al.  The effect of matrix stiffness on mesenchymal stem cell differentiation in a 3D thixotropic gel. , 2010, Biomaterials.

[21]  D. Seliktar.  Designing Cell-Compatible Hydrogels for Biomedical Applications , 2012, Science.

[22]  Dongan Wang,et al.  Hepatogenesis of murine induced pluripotent stem cells in 3D micro-cavitary hydrogel system for liver regeneration. , 2013, Biomaterials.

[23]  Mei Yang,et al.  Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction , 2013, Experimental Gerontology.

[24]  Jun Li,et al.  Controlled drug release from biodegradable thermoresponsive physical hydrogel nanofibers. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[25]  Stephanie J Bryant,et al.  Encapsulating chondrocytes in degrading PEG hydrogels with high modulus: Engineering gel structural changes to facilitate cartilaginous tissue production , 2004, Biotechnology and bioengineering.

[26]  Jan P. Stegemann,et al.  Matrix composition regulates three-dimensional network formation by endothelial cells and mesenchymal stem cells in collagen/fibrin materials , 2012, Angiogenesis.

[27]  J. Hubbell,et al.  Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering , 2005, Nature Biotechnology.

[28]  Allan S Hoffman,et al.  Hydrogels for biomedical applications. , 2002, Advanced drug delivery reviews.

[29]  P. Chan,et al.  Injectable 3D Hydrogel Scaffold with Tailorable Porosity Post‐Implantation , 2014, Advanced healthcare materials.

[30]  B. Ratner.  Reducing capsular thickness and enhancing angiogenesis around implant drug release systems. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[31]  A. Gefen,et al.  Thermosensitive hydrogel made of ferulic acid-gelatin and chitosan glycerophosphate. , 2013, Carbohydrate polymers.

[32]  Krishnendu Roy,et al.  Engineering articular cartilage with spatially-varying matrix composition and mechanical properties from a single stem cell population using a multi-layered hydrogel. , 2011, Biomaterials.

[33]  Jun Beom Park,et al.  The identification of a heparin binding domain peptide from bone morphogenetic protein-4 and its role on osteogenesis. , 2010, Biomaterials.

[34]  Myron Spector,et al.  Modulation of mesenchymal stem cell chondrogenesis in a tunable hyaluronic acid hydrogel microenvironment. , 2012, Biomaterials.

[35]  Ali Khademhosseini,et al.  Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels , 2012, Advanced functional materials.

[36]  A. Khademhosseini,et al.  Carbon nanotube reinforced hybrid microgels as scaffold materials for cell encapsulation. , 2012, ACS nano.

[37]  Mohammad Ali Shokrgozar,et al.  Enhanced mechanical properties of thermosensitive chitosan hydrogel by silk fibers for cartilage tissue engineering. , 2013, Materials science & engineering. C, Materials for biological applications.

[38]  Robert Langer,et al.  A 3D Interconnected Microchannel Network Formed in Gelatin by Sacrificial Shellac Microfibers , 2012, Advanced materials.

[39]  Yi Yan Yang,et al.  Injectable biodegradable hydrogels composed of hyaluronic acid-tyramine conjugates for drug delivery and tissue engineering. , 2005, Chemical communications.

[40]  S. Sen,et al.  Matrix Elasticity Directs Stem Cell Lineage Specification , 2006, Cell.

[41]  Stephanie J Bryant,et al.  The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)-based hydrogels. , 2012, Journal of biomedical materials research. Part A.

[42]  J. Burdick,et al.  Macromer density influences mesenchymal stem cell chondrogenesis and maturation in photocrosslinked hyaluronic acid hydrogels. , 2009, Osteoarthritis and cartilage.

[43]  M. Detamore,et al.  Tuning mechanical performance of poly(ethylene glycol) and agarose interpenetrating network hydrogels for cartilage tissue engineering. , 2013, Biomaterials.

[44]  J. West,et al.  A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[45]  Teck Chuan Lim,et al.  Chemotactic recruitment of adult neural progenitor cells into multifunctional hydrogels providing sustained SDF‐1α release and compatible structural support , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[46]  O. Scherman,et al.  Supramolecular polymeric hydrogels. , 2012, Chemical Society reviews.

[47]  Myeong-Jin Oh,et al.  Hollow polydimethylsiloxane beads with a porous structure for cell encapsulation. , 2013, Macromolecular rapid communications.

[48]  K. Anseth,et al.  The influence of the RGD peptide motif and its contextual presentation in PEG gels on human mesenchymal stem cell viability , 2008, Journal of tissue engineering and regenerative medicine.

[49]  Ruzhi Wang,et al.  Photodegradable supramolecular hydrogels with fluorescence turn-on reporter for photomodulation of cellular microenvironments. , 2013, Journal of the American Chemical Society.

[50]  Oren A Scherman,et al.  Sustained release of proteins from high water content supramolecular polymer hydrogels. , 2012, Biomaterials.

[51]  Wen-Hsuan Wu,et al.  Biodegradable ferulic acid-containing poly(anhydride-ester): degradation products with controlled release and sustained antioxidant activity. , 2013, Biomacromolecules.

[52]  C. Yeow,et al.  Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells. , 2010, Biomaterials.

[53]  Steffen Cosson,et al.  A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells. , 2014, Biomaterials.

[54]  Glenn D Prestwich,et al.  Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2. , 2012, Biomaterials.

[55]  D. Stewart,et al.  The effect of encapsulation of cardiac stem cells within matrix-enriched hydrogel capsules on cell survival, post-ischemic cell retention and cardiac function. , 2014, Biomaterials.

[56]  William L Lowe,et al.  Anti-inflammatory peptide-functionalized hydrogels for insulin-secreting cell encapsulation. , 2010, Biomaterials.

[57]  Jeff W Lichtman,et al.  Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors , 2009, Proceedings of the National Academy of Sciences.

[58]  Chaenyung Cha,et al.  Controlling mechanical properties of cell-laden hydrogels by covalent incorporation of graphene oxide. , 2014, Small.

[59]  Mikaël M. Martino,et al.  In Situ Cell Manipulation through Enzymatic Hydrogel Photopatterning , 2013 .

[60]  M. Kurisawa,et al.  Injectable biodegradable hydrogels with tunable mechanical properties for the stimulation of neurogenesic differentiation of human mesenchymal stem cells in 3D culture. , 2010, Biomaterials.

[61]  H. Vandenburgh,et al.  The role of multifunctional delivery scaffold in the ability of cultured myoblasts to promote muscle regeneration. , 2011, Biomaterials.

[62]  B. Newland,et al.  The reduction in immunogenicity of neurotrophin overexpressing stem cells after intra-striatal transplantation by encapsulation in an in situ gelling collagen hydrogel. , 2013, Biomaterials.

[63]  M. Kurisawa,et al.  Formation and stability of interpenetrating polymer network hydrogels consisting of fibrin and hyaluronic acid for tissue engineering. , 2013, Acta biomaterialia.