Effects of steroidal and non-steroidal anti-inflammatory agents on corneal wound healing.

This study was designed to compare corticosteroids with ketorolac, a non steroidal anti-inflammatory drug on corneal wound healing in rabbits. The present studies indicate that 0.5% ketorolac does not significantly impair wound healing as determined by corneal tensile strength, whereas 0.1% solution of dexamethasane phosphate resulted in a significant impairment of wound healing. In addition, ketorolac does not impair healing of corneal epithelial abrasion, whereas prednisolone acetate was found to impair wound healing. The development of a non-steroidal anti-inflammatory drug such as ketorolac provides an alternative method to suppress post-surgical inflammation and does not adversely affect the cellular system involved in corneal repair.

[1]  D. Miller,et al.  Effects of prednisolone and medroxyprogesterone on corneal wound healing, ulceration, and neovascularization. , 1983, Archives of ophthalmology.

[2]  R. D. Legrand,et al.  Inhibition of adenylate cyclase activity in the corneal epithelium by anti-inflammatory steroids. , 1982, Experimental eye research.

[3]  D. Miller,et al.  Topical flurbiprofen or prednisolone. Effect on corneal wound healing in rabbits. , 1981, Archives of ophthalmology.

[4]  B. Schimmelpfennig,et al.  Sensory denervation of the rabbit cornea affects epithelial properties , 1980, Experimental Neurology.

[5]  J. Sugar,et al.  Experimental Corneal Wound Strength: Effect of Topically Applied Corticosteroids , 1974 .

[6]  A. Gasset,et al.  The tensile strength of corneal wounds. , 1968, Archives of ophthalmology.

[7]  A. Gasset,et al.  CORTICOSTEROIDS IN CORNEAL WOUND HEALING. , 1964, American journal of ophthalmology.

[8]  Geeraets Wj,et al.  Corticosteroids and corneal wound-healing. , 1959, Eye, ear, nose & throat monthly.

[9]  E. S. Palmerton.  The effect of local cortisone on wound healing in rabbit corneas. , 1955, American journal of ophthalmology.

[10]  L. Tanenbaum,et al.  The analgesic and anti-inflammatory profile of ketorolac and its tromethamine salt. , 1985, Drugs under experimental and clinical research.

[11]  L. Waterbury,et al.  Drug effects on the neovascularization response to silver nitrate cauterization of the rat cornea. , 1985, Current eye research.