Survival following a diagnosis of heart failure in primary care

Abstract Background. Heart failure is a common long term condition affecting around 900 000 people in the UK and patients commonly present to primary care. The prognosis of patients with a code of heart failure in their primary care record is unknown. Objective. The study sought to determine the overall survival rates for patients with heart failure in a primary care population from the time of diagnosis. Methods. Survival analysis was carried out using UK primary care records from The Health Improvement Network (THIN) between 1 January 1998 and 31 December 2012. Patients age 45 or over with a first diagnostic label of heart failure were matched by age, sex and practice to people without heart failure. Outcome was death in the heart failure and no heart failure cohorts. Kaplan-Meier curves were used to compare survival. Age-specific survival rates at 1, 5 and 10 years were determined for men and women with heart failure. Survival rates by year of diagnosis and case definition were also calculated. Results. During the study period, 54313 patients had a first diagnostic code of heart failure. Overall survival rates for the heart failure group were 81.3% (95%CI 80.9–81.6), 51.5% (95%CI 51.0–52.0) and 29.5% (95%CI 28.9–30.2) at 1, 5 and 10 years respectively and did not change over time. Conclusions. In a primary care population, the survival of patients diagnosed with heart failure did not improved over time. Further research is needed to explain these trends and to find strategies to improve outlook.

[1]  K. White,et al.  Clinical epidemiology. , 1983, International journal of epidemiology.

[2]  Daniel Levy,et al.  Long-term trends in the incidence of and survival with heart failure. , 2002, The New England journal of medicine.

[3]  Harlan M Krumholz,et al.  Trajectories of risk after hospitalization for heart failure, acute myocardial infarction, or pneumonia: retrospective cohort study , 2015, BMJ : British Medical Journal.

[4]  Simon Capewell,et al.  The current cost of heart failure to the National Health Service in the UK , 2002, European journal of heart failure.

[5]  N. Bayley,et al.  Failure , 1890, The Hospital.

[6]  M. Davies,et al.  Prognosis of all-cause heart failure and borderline left ventricular systolic dysfunction: 5 year mortality follow-up of the Echocardiographic Heart of England Screening Study (ECHOES). , 2007, European heart journal.

[7]  E. Braunwald The war against heart failure: the Lancet lecture , 2015, The Lancet.

[8]  M. Kodama,et al.  Burden of Systolic and Diastolic Ventricular Dysfunction in the Community (Preventive Medicine/Epidemiology/Education/Health Policy 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society) , 2005 .

[9]  Colin Simpson,et al.  Long-Term Trends in First Hospitalization for Heart Failure and Subsequent Survival Between 1986 and 2003: A Population Study of 5.1 Million People , 2009, Circulation.

[10]  A. Maguire,et al.  The importance of defining periods of complete mortality reporting for research using automated data from primary care , 2009, Pharmacoepidemiology and drug safety.

[11]  S. Muller,et al.  Electronic medical records: the way forward for primary care research? , 2014, Family practice.

[12]  I. Higginson,et al.  Improving generalist end of life care: national consultation with practitioners, commissioners, academics, and service user groups , 2008, BMJ : British Medical Journal.

[13]  Thomas Kahan,et al.  The epidemiology of heart failure, based on data for 2.1 million inhabitants in Sweden , 2013, European journal of heart failure.

[14]  Evangelos Kontopantelis,et al.  Effect of financial incentives on incentivised and non-incentivised clinical activities: longitudinal analysis of data from the UK Quality and Outcomes Framework , 2011, BMJ : British Medical Journal.

[15]  C. Thieke,et al.  Long-term survival of cancer patients compared to heart failure and stroke: A systematic review , 2010, BMC Cancer.

[16]  S Capewell,et al.  More ‘malignant’ than cancer? Five‐year survival following a first admission for heart failure , 2001, European journal of heart failure.

[17]  A. Bourke,et al.  Generalisability of The Health Improvement Network (THIN) database: demographics, chronic disease prevalence and mortality rates. , 2011, Informatics in primary care.

[18]  Karl Swedberg,et al.  Predicting survival in heart failure: a risk score based on 39 372 patients from 30 studies. , 2013, European heart journal.

[19]  A. Hoes,et al.  Clinical epidemiology of heart failure , 2007, Heart.