Hyperpolarized helium-3 MR imaging of pulmonary function.

Recent advances in HP MR imaging contrast agents have led to novel tests of pulmonary function. Many of these tests show promise in the clinical arena.

[1]  P. Wagner Ventilation/perfusion relationships. , 1981, Clinical physiology.

[2]  D. Yablonskiy,et al.  MR imaging of diffusion of 3He gas in healthy and diseased lungs , 2000, Magnetic resonance in medicine.

[3]  H C Charles,et al.  Human lung air spaces: potential for MR imaging with hyperpolarized He-3. , 1996, Radiology.

[4]  H. Kauczor,et al.  Assessment of a single‐acquisition imaging sequence for oxygen‐sensitive 3He‐MRI , 2002, Magnetic resonance in medicine.

[5]  W. Thurlbeck Overview of the pathology of pulmonary emphysema in the human. , 1983, Clinics in laboratory medicine.

[6]  L W Hedlund,et al.  Dynamics of magnetization in hyperpolarized gas MRI of the lung , 1997, Magnetic resonance in medicine.

[7]  L. Hedlund,et al.  MR Imaging with Hyperpolarized 3He Gas , 1995, Magnetic resonance in medicine.

[8]  J. Roca,et al.  Airway obstruction and ventilation-perfusion relationships in acute severe asthma. , 1993, The American review of respiratory disease.

[9]  Cates,et al.  Relaxation of spins due to field inhomogeneities in gaseous samples at low magnetic fields and low pressures. , 1988, Physical review. A, General physics.

[10]  Peter D. Wagner,et al.  8 – Numerical Analysis of Gas Exchange , 1980 .

[11]  G. Snider Chronic obstructive pulmonary disease: a definition and implications of structural determinants of airflow obstruction for epidemiology. , 1989, The American review of respiratory disease.

[12]  R. Bartlett,et al.  Pulmonary compliance and mechanical ventilation. , 1992, Archives of surgery.

[13]  R. Rizi,et al.  Detection of simulated pulmonary embolism in a porcine model using hyperpolarized 3He MRI , 2004, Magnetic resonance in medicine.

[14]  Wu,et al.  Coherent interactions of the polarized nuclear spins of gaseous atoms with the container walls. , 1988, Physical review. A, General physics.

[15]  N Weiler,et al.  Quantification of regional intrapulmonary oxygen partial pressure evolution during apnea by (3)He MRI. , 1999, Journal of magnetic resonance.

[16]  J. West,et al.  Gas Exchange after Pulmonary Thromboembolization in Dogs , 1978, Circulation research.

[17]  M. Bock Simultaneous T2* and diffusion measurements with 3He , 1997, Magnetic resonance in medicine.

[18]  Barton,et al.  Gaseous 3He-3He magnetic dipolar spin relaxation. , 1993, Physical review. A, Atomic, molecular, and optical physics.

[19]  L W Hedlund,et al.  Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: Diffusion coefficient , 1999, Magnetic resonance in medicine.

[20]  Middleton,et al.  Nuclear relaxation of 3He in the presence of O2. , 1995, Physical review. A, Atomic, molecular, and optical physics.

[21]  T A Altes,et al.  Hyperpolarized 3He MR lung ventilation imaging in asthmatics: Preliminary findings , 2001, Journal of magnetic resonance imaging : JMRI.

[22]  White,et al.  Spin relaxation in gases due to inhomogeneous static and oscillating magnetic fields. , 1988, Physical review. A, General physics.

[23]  J B West,et al.  Ventilation-perfusion inequality and overall gas exchange in computer models of the lung. , 1969, Respiration physiology.

[24]  Peter D. Wagner,et al.  Continuous Distributions of Ventilation-Perfusion Ratios in Normal Subjects Breathing Air and 100% O2 , 1974 .

[25]  T. Jones,et al.  Quantification of regional V/Q ratios in humans by use of PET. I. Theory. , 1989, Journal of applied physiology.

[26]  G. K. Walters,et al.  NUCLEAR SPIN-LATTICE RELAXATION IN THE PRESENCE OF MAGNETIC-FIELD GRADIENTS , 1965 .

[27]  M P Hlastala,et al.  A model of fluctuating alveolar gas exchange during the respiratory cycle. , 1972, Respiration physiology.

[28]  Peter Magnusson,et al.  Quantitative measurement of regional lung ventilation using 3He MRI , 2002, Magnetic resonance in medicine.

[29]  H. Kauczor,et al.  Flip angle considerations in 3Helium‐MRI , 2000, NMR in biomedicine.

[30]  Dmitriy A Yablonskiy,et al.  Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[31]  A. Harf,et al.  Distribution of ventilation/perfusion ratios in pulmonary embolism: an adjunct to the interpretation of ventilation/perfusion lung scans. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[32]  S. Kety The theory and applications of the exchange of inert gas at the lungs and tissues. , 1951, Pharmacological reviews.

[33]  J. Severinghaus Simple, accurate equations for human blood O2 dissociation computations. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[34]  H. Kauczor,et al.  3He‐MRI‐based measurements of intrapulmonary p O2 and its time course during apnea in healthy volunteers: first results, reproducibility, and technical limitations , 2000, NMR in biomedicine.

[35]  N. Zamel,et al.  Lung elastic recoil in acute and chronic asthma , 2002, Current opinion in pulmonary medicine.

[36]  R. Rizi,et al.  Determination of regional VA/Q by hyperpolarized 3He MRI , 2004, Magnetic resonance in medicine.

[37]  G. Gibson,et al.  Lung volumes and elasticity. , 2001, Clinics in chest medicine.

[38]  J R MacFall,et al.  Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T∗︁2 , 1999, Magnetic resonance in medicine.

[39]  John,et al.  Blood gas calculator. , 1966, Journal of applied physiology.

[40]  C. L. Bartberger The Magnetic Field of a Plane Circular Loop , 1950 .

[41]  R. Rizi,et al.  Single‐acquisition sequence for the measurement of oxygen partial pressure by hyperpolarized gas MRI , 2004, Magnetic resonance in medicine.

[42]  J. West,et al.  7 – Ventilation–Perfusion Relationships , 1980 .

[43]  R. Crystal,et al.  The Lung: Scientific Foundations , 1991 .

[44]  John P Mugler,et al.  Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes--initial experience. , 2002, Radiology.

[45]  J B West,et al.  Measurement of continuous distributions of ventilation-perfusion ratios: theory. , 1974, Journal of applied physiology.

[46]  Interpretation of the Temperature Autostabilization of a Ferroelectric Crystal , 1965 .