Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT(2A) and 5-HT(3) receptors.

[1]  M. Ishizuka,et al.  Inhibitory effects of dopamine on spinal synaptic transmission via dopamine D1‐like receptors in neonatal rats , 2012, British journal of pharmacology.

[2]  S. Ito,et al.  Differential contributions of adenosine to hypoxia‐evoked depressions of three neuronal pathways in isolated spinal cord of neonatal rats , 2011, British journal of pharmacology.

[3]  B. Meyerson,et al.  Spinal 5-HT receptors that contribute to the pain-relieving effects of spinal cord stimulation in a rat model of neuropathy , 2011, PAIN®.

[4]  A. Dogrul,et al.  Systemic cannabinoids produce CB₁-mediated antinociception by activation of descending serotonergic pathways that act upon spinal 5-HT(7) and 5-HT(2A) receptors. , 2010, European journal of pharmacology.

[5]  H. Kimura,et al.  Presynaptic inhibition of primary afferents by depolarization: observations supporting nontraditional mechanisms , 2010, Annals of the New York Academy of Sciences.

[6]  Y. Yanagawa,et al.  Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn. , 2009, Journal of neurophysiology.

[7]  F. Porreca,et al.  Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors , 2009, Brain Research.

[8]  Keir G. Pearson,et al.  Descending command systems for the initiation of locomotion in mammals , 2008, Brain Research Reviews.

[9]  Manfred Göthert,et al.  5-HT Receptor Regulation of Neurotransmitter Release , 2007, Pharmacological Reviews.

[10]  S. Ito,et al.  Zinc modulates primary afferent fiber-evoked responses of ventral roots in neonatal rat spinal cord in vitro , 2006, Neuroscience.

[11]  M. Tanabe,et al.  Fluvoxamine, a selective serotonin reuptake inhibitor, exerts its antiallodynic effects on neuropathic pain in mice via 5-HT2A/2C receptors , 2006, Neuropharmacology.

[12]  H. Furue,et al.  Mechanisms for the anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord. , 2006, Journal of pharmacological sciences.

[13]  D. Vergé,et al.  Pre‐ and postsynaptic localization of the 5‐HT7 receptor in rat dorsal spinal cord: Immunocytochemical evidence , 2005, The Journal of comparative neurology.

[14]  V. Granados-Soto,et al.  Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin test , 2005, Pain.

[15]  S. Ito,et al.  Effects of opioid receptor and alpha2-adrenoceptor agonists on slow ventral root potentials and on capsaicin and formalin tests in neonatal rats. , 2005, Brain research. Developmental brain research.

[16]  H. Schaible,et al.  Descending control of persistent pain: inhibitory or facilitatory? , 2004, Brain Research Reviews.

[17]  P. Pauwels,et al.  Pharmacology of cloned human 5-HT1D receptor-mediated functional responses in stably transfected rat C6-glial cell lines: further evidence differentiating human 5-HT1D and 5-HT1B receptors , 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

[18]  J. Lopez-Garcia,et al.  Role of serotonin1A receptors on the modulation of rat spinal mono-synaptic reflexes in vitro , 2002, Neuroscience Letters.

[19]  J. Lopez-Garcia,et al.  5‐HT1B but not 5‐HT6 or 5‐HT7 receptors mediate depression of spinal nociceptive reflexes in vitro , 2002, British journal of pharmacology.

[20]  A. Eschalier,et al.  5-HT receptor subtypes involved in the spinal antinociceptive effect of acetaminophen in rats. , 2001, European journal of pharmacology.

[21]  E. Kirkness,et al.  5‐HT3‐receptor subunits A and B are co‐expressed in neurons of the dorsal root ganglion , 2001 .

[22]  R. Miledi,et al.  Distribution of serotonin 2A, 2C and 3 receptor mRNA in spinal cord and medulla oblongata. , 2001, Brain research. Molecular brain research.

[23]  T. Goto,et al.  The antinociceptive effect induced by FR140423 is mediated through spinal 5-HT2A and 5-HT3 receptors. , 2000, European journal of pharmacology.

[24]  A. Eschalier,et al.  Serotonin receptor subtypes involved in the spinal antinociceptive effect of 5-HT in rats , 2000, Pain.

[25]  L. Vyklický.  Presynaptic Inhibition , 1999, Science.

[26]  R. Roth,et al.  5-HT2 Receptor Regulation of Extracellular GABA Levels in the Prefrontal Cortex , 1999, Neuropsychopharmacology.

[27]  R. Andrade,et al.  5-Hydroxytryptamine2 receptor facilitates GABAergic neurotransmission in rat hippocampus. , 1998, The Journal of pharmacology and experimental therapeutics.

[28]  E. Faber,et al.  Depression of A and C fibre‐evoked segmental reflexes by morphine and clonidine in the in vitro spinal cord of the neonatal rat , 1997, British journal of pharmacology.

[29]  J. Giordano.  Antinociceptive effects of intrathecally administered 2-methylserotonin in developing rats. , 1997, Brain research. Developmental brain research.

[30]  A. Akaike,et al.  Dual effect of serotonin on formalin-induced nociception in the rat spinal cord , 1996, Neuroscience Research.

[31]  S. Barasi,et al.  The role of 5HT3 in nociceptive processing in the rat spinal cord: results from behavioural and electrophysiological studies , 1996, Neuroscience Letters.

[32]  N. A. Manuel,et al.  Ketanserin‐sensitive depressant actions of 5‐HT receptor agonists in the neonatal rat spinal cord , 1995, British journal of pharmacology.

[33]  J. Stamford.  Descending control of pain. , 1995, British journal of anaesthesia.

[34]  N. A. Manuel,et al.  A novel 5-HT receptor or a combination of 5-HT receptor subtypes may mediate depression of a spinal monosynaptic reflex in vitro , 1994, Neuropharmacology.

[35]  J. Wu,et al.  Is 5-hydroxytryptamine mediating descending inhibition in the neonatal rat spinal cord through different receptor subtypes? , 1993, European Journal of Pharmacology.

[36]  X. Langlois,et al.  5-HT3 receptors in the rat central nervous system are mainly located on nerve fibres and terminals , 1993, Brain Research.

[37]  D. I. Lewis,et al.  Excitatory and indirect inhibitory actions of 5-hydroxytryptamine on sympathetic preganglionic neurones in the neonate rat spinal cord in vitro , 1993, Brain Research.

[38]  X. Wang,et al.  Descending inhibition in the neonate rat spinal cord is mediated by 5-hydroxytryptamine , 1993, Neuropharmacology.

[39]  H. Suzuki,et al.  Serotonergic fibers induce a long-lasting inhibition of monosynaptic reflex in the neonatal rat spinal cord , 1992, Neuroscience.

[40]  D. Wallis,et al.  Serotonin andl-norepinephrine as mediators of altered excitability in neonatal rat motoneurons studied in vitro , 1992, Neuroscience.

[41]  J. Kendig,et al.  Substance P and NMDA receptors mediate a slow nociceptive ventral root potential in neonatal rat spinal cord , 1991, Brain Research.

[42]  H. Crick,et al.  Inhibition of reflex responses of neonate rat lumbar spinal cord by 5‐hydroxytryptamine , 1991, British journal of pharmacology.

[43]  G. Wilcox,et al.  Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[44]  J. Teilhac,et al.  Autoradiographic mapping of 5-HT1, 5-HT1A, 5-HT1B and 5-HT2 receptors in the rat spinal cord , 1991, Brain Research.

[45]  M. Maze,et al.  α2-Adrenoceptors inhibit a nociceptive response in neonatal rat spinal cord , 1991 .

[46]  M. Otsuka,et al.  Pharmacological properties of a C‐fibre response evoked by saphenous nerve stimulation in an isolated spinal cord‐nerve preparation of the newborn rat , 1989, British journal of pharmacology.

[47]  M. Hamon,et al.  5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord. , 1989, European journal of pharmacology.

[48]  M. Yanagisawa,et al.  GABAergic modulation of a substance P‐mediated reflex of slow time course in the isolated rat spinal cord , 1987, British journal of pharmacology.

[49]  S. Konishi,et al.  The role of substance P as a neurotransmitter in the reflexes of slow time courses in the neonatal rat spinal cord , 1985, British journal of pharmacology.

[50]  T. Murakoshi,et al.  Tail-pinch method in vitro and the effects of some antinociceptive compounds , 1984 .