Burn injuries

Purpose of review To summarize new advances and research findings that relate to the treatment of burn victims. Recent findings Recent advances in burn resuscitation and critical care reflect a better understanding of the acute phase pathophysiology of severe burns. Aggressive management of the unstable burn airway is always the most important clinical priority. Emphasis has been placed on the early identification of inhalation injury and its impact on fluid resuscitation, as well as on a protective lung strategy to reduce the development of pulmonary edema, acute lung injury and pneumonia, and to reduce the risk of barotrauma. New blood markers, such as serum cholinesterase and inflammatory cytokines, have been introduced to assist in the prognosis of morbidity and mortality, beyond the traditional vital signs. At this time, however, these are available only for research purposes. Finally, early burn wound excision and coverage with new biodegradable materials results in less pain and more rapid healing for the patient. Summary The combination of innovative approaches and a dedicated burn team is expected to continue to improve survival in the next few years even in the most severe cases.

[1]  C. Ryan,et al.  Incidence, outcome, and long-term consequences of herpes simplex virus type 1 reactivation presenting as a facial rash in intubated adult burn patients treated with acyclovir. , 2002, The Journal of trauma.

[2]  C. Schulman,et al.  Mechanisms of Pulmonary Microvascular Dysfunction during Severe Burn Injury , 2002, World Journal of Surgery.

[3]  C. Holm,et al.  Effect of crystalloid resuscitation and inhalation injury on extravascular lung water: clinical implications. , 2002, Chest.

[4]  E. Kesiktaş,et al.  A retrospective analysis of 1083 Turkish patients with serious burns. Part 2: burn care, survival and mortality. , 2002, Burns : journal of the International Society for Burn Injuries.

[5]  Nabil Wasif,et al.  Diabetes and burns: retrospective cohort study. , 2002, The Journal of burn care & rehabilitation.

[6]  G. Su,et al.  Thermal injury induces expression of CD14 in human skin. , 2002, Burns : journal of the International Society for Burn Injuries.

[7]  M. Mckenney,et al.  Unexpected findings in trauma patients dying in the intensive care unit: results of 153 consecutive autopsies. , 2002, Journal of the American College of Surgeons.

[8]  K. Jablonski,et al.  Serum lactate, not base deficit, rapidly predicts survival after major burns. , 2002, Burns : journal of the International Society for Burn Injuries.

[9]  K. Iida,et al.  Circulating blood volume in burn resuscitation. , 2002, Hiroshima journal of medical sciences.

[10]  D. Herndon,et al.  Modulating the hypermetabolic response to burn injuries. , 2002, Journal of wound care.

[11]  T. Shimazu,et al.  Long-term enhanced expression of heat shock proteins and decelerated apoptosis in polymorphonuclear leukocytes from major burn patients. , 2002, The Journal of burn care & rehabilitation.

[12]  C. Yowler,et al.  Burns with Multiple Trauma , 2002, The American surgeon.

[13]  L. Kamolz,et al.  Serum cholinesterase activity reflects morbidity in burned patients. , 2002, Burns : journal of the International Society for Burn Injuries.

[14]  M. Zimpfer,et al.  Impact of duodenal feeding on the oxygen balance of the splanchnic region during different phases of severe burn injury. , 2002, Burns : journal of the International Society for Burn Injuries.

[15]  M. O'mara,et al.  Helicopter transportation of burn patients. , 2002, Burns : journal of the International Society for Burn Injuries.

[16]  C. Polanczyk,et al.  Association between early detection of soluble TNF-receptors and mortality in burn patients , 2002, Intensive Care Medicine.

[17]  A. Munster,et al.  The long-term consequences of lightning injuries. , 2001, Burns : journal of the International Society for Burn Injuries.

[18]  L. Gottlieb,et al.  Glutamine administration reduces Gram-negative bacteremia in severely burned patients: A prospective, randomized, double-blind trial versus isonitrogenous control , 2001, Critical care medicine.

[19]  P. Esselman,et al.  Time off work and return to work rates after burns: systematic review of the literature and a large two-center series. , 2001, The Journal of burn care & rehabilitation.

[20]  D. Heimbach,et al.  Rates, trends, and severity of depression after burn injuries. , 2001, The Journal of burn care & rehabilitation.

[21]  H. Kehlet,et al.  Analgesic Effects of Dexamethasone in Burn Injury , 2001, Regional Anesthesia & Pain Medicine.

[22]  M. Cushman,et al.  Management of multiple burn casualties in a high volume ED without a verified burn unit. , 2001, The American journal of emergency medicine.

[23]  J. Coakley,et al.  Pathogenesis and recovery of tetraplegia after electrical injury , 2001, Journal of neurology, neurosurgery, and psychiatry.

[24]  R. Wolfe,et al.  Testosterone administration in severe burns ameliorates muscle catabolism , 2001, Critical care medicine.

[25]  A H Roberts,et al.  The influence of body mass index on burn surface area estimated from the area of the hand. , 2001, Burns : journal of the International Society for Burn Injuries.

[26]  K. Kowalske,et al.  Neuropathy after burn injury. , 2001, The Journal of burn care & rehabilitation.

[27]  N. Aikawa,et al.  Elevation of plasma free PAI-1 levels as an integrated endothelial response to severe burns. , 2001, Burns : journal of the International Society for Burn Injuries.

[28]  T. Cubison,et al.  Treatment before transfer: the patient with burns , 2001, Emergency medicine journal : EMJ.

[29]  L. Wibbenmeyer,et al.  Predicting survival in an elderly burn patient population. , 2001, Burns : journal of the International Society for Burn Injuries.

[30]  J. Hunt,et al.  Differential activation of coronary and pulmonary endothelial cells by thermal injury. , 2001, Shock.

[31]  J. Fish,et al.  Early clinical experience with high-frequency oscillatory ventilation for ARDS in adult burn patients. , 2001, The Journal of burn care & rehabilitation.

[32]  S. Lal,et al.  Determinants of blood loss during primary burn excision. , 2001, Surgery.

[33]  A. M. Kahn,et al.  Management of burn injuries during pregnancy. , 2001, Burns : journal of the International Society for Burn Injuries.

[34]  R. Sheridan,et al.  Trends in blood conservation in burn care. , 2001, Burns : journal of the International Society for Burn Injuries.

[35]  M. A. de la Cal,et al.  Pneumonia in patients with severe burns : a classification according to the concept of the carrier state. , 2001, Chest.

[36]  M. rule,et al.  Determinants of death following burn injury , 2001, The British journal of surgery.

[37]  R. Gamelli,et al.  The impact of antithrombin (H) concentrate infusions on pulmonary function in the acute phase of thermal injury. , 2001, Burns : journal of the International Society for Burn Injuries.

[38]  G. O’Keefe,et al.  An evaluation of risk factors for mortality after burn trauma and the identification of gender-dependent differences in outcomes. , 2001, Journal of the American College of Surgeons.

[39]  S. Ying,et al.  Corneal perforation with extrusion of lens in a burn patient. , 2001, Burns : journal of the International Society for Burn Injuries.

[40]  R. Demling,et al.  Comparison of the anabolic effects and complications of human growth hormone and the testosterone analog, oxandrolone, after severe burn injury. , 1999, Burns : journal of the International Society for Burn Injuries.

[41]  G. Wells,et al.  A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. , 1999, The New England journal of medicine.

[42]  A. Vanderkelen,et al.  The usefulness of combined high-frequency percussive ventilation during acute respiratory failure after smoke inhalation. , 1998, Burns : journal of the International Society for Burn Injuries.

[43]  Raphael C. Lee,et al.  The physicochemical basis for thermal and non-thermal 'burn' injuries. , 1996, Burns : journal of the International Society for Burn Injuries.

[44]  L. Rue,et al.  Hypertonic sodium resuscitation is associated with renal failure and death. , 1995, Annals of surgery.

[45]  P A Ward,et al.  Pathophysiologic events related to thermal injury of skin. , 1990, The Journal of trauma.

[46]  R. Edlich,et al.  Prediction of burn mortality. , 1982, Surgery, gynecology & obstetrics.

[47]  E. Diem,et al.  [Modern burn care]. , 1977, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete.

[48]  D. Heimbach,et al.  Inpatient depression in persons with burns. , 2002, The Journal of burn care & rehabilitation.

[49]  Günter Germann,et al.  Transcardiopulmonary vs pulmonary arterial thermodilution methods for hemodynamic monitoring of burned patients. , 2002, The Journal of burn care & rehabilitation.

[50]  J. Fish,et al.  Reduced blood loss during burn surgery. , 2001, The Journal of burn care & rehabilitation.

[51]  C. Yowler,et al.  Current status of burn resuscitation. , 2000, Clinics in plastic surgery.

[52]  X. Rong,et al.  Successful recovery of 14 patients afflicted with full-thickness burns for more than 70 per cent body surface area. , 1998, Burns : journal of the International Society for Burn Injuries.