Imaging Update: New Windows, New Views

The recent progress in our understanding of the molecular-genetic mechanisms active in many diseases and the application of new biologically based approaches in therapy are exciting new developments that have emerged following mapping of the human genome. Novel “molecular therapies” have been

[1]  Jürg Zimmermann,et al.  Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells , 1996, Nature Medicine.

[2]  T. Jacks,et al.  STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications , 2001, Oncogene.

[3]  Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[4]  R. Blasberg,et al.  Human reporter genes: potential use in clinical studies. , 2007, Nuclear medicine and biology.

[5]  R. Blasberg,et al.  Multi-modality molecular imaging of tumors. , 2006, Hematology/oncology clinics of North America.

[6]  Robert M. Hoffman,et al.  The multiple uses of fluorescent proteins to visualize cancer in vivo , 2005, Nature Reviews Cancer.

[7]  J. Barrio,et al.  Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients. , 2005, Gastroenterology.

[8]  A. Nagy,et al.  Embryonic stem cells and mice expressing different GFP variants for multiple non-invasive reporter usage within a single animal , 2002, BMC biotechnology.

[9]  C. Löwik,et al.  Whole-Body Optical Imaging in Animal Models to Assess Cancer Development and Progression , 2007, Clinical Cancer Research.

[10]  K Wienhard,et al.  Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas , 2001, The Lancet.

[11]  R. Weissleder.  Scaling down imaging: molecular mapping of cancer in mice , 2002, Nature Reviews Cancer.

[12]  H. Wester,et al.  Nuclear Imaging Probes: from Bench to Bedside , 2007, Clinical Cancer Research.

[13]  M. Nerenberg,et al.  Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter control , 1990, Neuron.

[14]  R. Weissleder,et al.  MRI of transgene expression: correlation to therapeutic gene expression. , 2002, Neoplasia.

[15]  T. Choueiri,et al.  The current role of angiogenesis inhibitors in the treatment of renal cell carcinoma. , 2006, Seminars in oncology.

[16]  Patricia L. Harris,et al.  Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. , 2004, The New England journal of medicine.

[17]  C. Contag,et al.  Advancing animal models of neoplasia through in vivo bioluminescence imaging. , 2002, European journal of cancer.

[18]  W. Kaelin,et al.  Molecular pathways in renal cell carcinoma--rationale for targeted treatment. , 2006, Seminars in oncology.