Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Novel Biomarkers of Primary Open-Angle Glaucoma

Purpose:We aimed to assess the levels of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with primary open-angle glaucoma (POAG) and to compare the NLR and PLR results of patients with POAG and ocular hypertension, as well as in healthy controls. Patients and Methods:Eighty-four patients with POAG, 94 patients with ocular hypertension, and 80 healthy subjects were enrolled in this retrospective study. Complete ophthalmological examination and complete blood count measurements were performed for all subjects. Results:There was a significant difference in the NLR (P=0.003) and PLR (P=0.049) between POAG and control groups. In addition, there was a correlation between pattern standard deviation and NLR in the POAG group. The receiver operating characteristics analysis revealed that the value of NLR to distinguish patients with POAG and controls was found to be 0.651. The best cutoff value was 2.1, with a sensitivity of 65% and a specificity of 65%. Conclusions:Our study for the first time provides evidence that NLR and PLR may be useful as biomarkers in patients with POAG.

[1]  J. Castillo,et al.  The neutrophil-to-lymphocyte ratio is an independent prognostic factor in patients with peripheral T-cell lymphoma, unspecified , 2016, Leukemia & lymphoma.

[2]  E. Sertoğlu,et al.  Accurate Use of Neutrophil/Lymphocyte Ratio in Patients with Age-related Macular Degeneration , 2014, Ocular immunology and inflammation.

[3]  T. Güngör,et al.  Two new inflammatory markers associated with Disease Activity Score‐28 in patients with rheumatoid arthritis: neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio , 2015, International journal of rheumatic diseases.

[4]  Hilal Kahraman,et al.  Assessment of Neutrophil/Lymphocyte Ratio in Patients with Age-related Macular Degeneration , 2015, Ocular immunology and inflammation.

[5]  A. Ejaz,et al.  Neutrophil‐lymphocyte and platelet‐lymphocyte ratio in patients after resection for hepato‐pancreatico‐biliary malignancies , 2015, Journal of surgical oncology.

[6]  Ying Li,et al.  Neutrophil-Lymphocyte ratio is associated with arterial stiffness in diabetic retinopathy in type 2 diabetes. , 2015, Journal of diabetes and its complications.

[7]  A. V. Ozeç,et al.  Association of Neutrophil/Lymphocyte Ratio and Retinal Vein Occlusion , 2015 .

[8]  Emine Esra Karaca,et al.  Neutrophil-to-Lymphocyte Ratio May Predict Progression in Patients With Keratoconus , 2014, Cornea.

[9]  M. Bozbay,et al.  Neutrophil-to-lymphocyte ratio as a prognostic marker in infective endocarditis: in-hospital and long-term clinical results. , 2014, The Journal of heart valve disease.

[10]  Mirjana Janićijević-Petrović,et al.  Evaluation of central corneal thickness in patients with ocular hypertension and primary open-angle glaucoma. , 2014, Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina.

[11]  S. Inan,et al.  Neutrophil-to-lymphocyte ratio as a quick and reliable predictive marker to diagnose the severity of diabetic retinopathy. , 2013, Diabetes technology & therapeutics.

[12]  E. Campos,et al.  Endothelin-1 plasma levels and vascular endothelial dysfunction in primary open angle glaucoma. , 2012, Life sciences.

[13]  J. Crowston,et al.  Is primary open‐angle glaucoma part of a generalized sensory neurodegeneration? A review of the evidence , 2012, Clinical & experimental ophthalmology.

[14]  C. Cheung,et al.  Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes , 2012, Molecular vision.

[15]  M. Wax.  The case for autoimmunity in glaucoma. , 2011, Experimental eye research.

[16]  K. Rezaei,et al.  Multiplex cytokine analysis reveals elevated concentration of interleukin-8 in glaucomatous aqueous humor. , 2010, Investigative ophthalmology & visual science.

[17]  H. Abe,et al.  Tumor necrosis factor-alpha concentrations in the aqueous humor of patients with glaucoma. , 2010, Investigative ophthalmology & visual science.

[18]  D. Liao,et al.  Serum Cytokine Alteration is Associated With Optic Neuropathy in Human Primary Open Angle Glaucoma , 2009, Journal of glaucoma.

[19]  A. Coleman,et al.  The logic behind target intraocular pressure. , 2009, American journal of ophthalmology.

[20]  F. Salazar-Onfray,et al.  Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape. , 2007, Cytokine & growth factor reviews.

[21]  C. Creuzot-Garcher,et al.  Measurement of inflammatory cytokines by multicytokine assay in tears of patients with glaucoma topically treated with chronic drugs , 2006, British Journal of Ophthalmology.

[22]  A. Kesler,et al.  C-Reactive Protein Levels in Normal Tension Glaucoma , 2005, Journal of glaucoma.

[23]  N. Pfeiffer,et al.  Analysis of Autoantibody Repertoires in Sera of Patients with Glaucoma , 2003, European journal of ophthalmology.

[24]  E. Stefánsson,et al.  The impact of ocular blood flow in glaucoma , 2002, Progress in Retinal and Eye Research.

[25]  M. Wax,et al.  TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes. , 2001, Investigative ophthalmology & visual science.

[26]  M. Wax,et al.  Serum autoantibody against glutathione S-transferase in patients with glaucoma. , 2001, Investigative ophthalmology & visual science.

[27]  Yoko Ikeda,et al.  Retinal ganglion cells recognized by serum autoantibody against gamma-enolase found in glaucoma patients. , 2000, Investigative ophthalmology & visual science.

[28]  M. Wax,et al.  Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes. , 2000, Archives of ophthalmology.

[29]  G Bellone,et al.  Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients. , 1999, The American journal of pathology.

[30]  M. Wax,et al.  Serum autoantibodies to optic nerve head glycosaminoglycans in patients with glaucoma. , 1999, Archives of ophthalmology.

[31]  A. Pestronk,et al.  Anti-rhodopsin antibodies in sera from patients with normal-pressure glaucoma. , 1995, Investigative ophthalmology & visual science.