The Efficacy and Safety of Cyclosporin A in Pregnant Patients with Systemic Autoimmune Diseases

Cyclosporin A (CYS A) is an immunosuppressant agent administered in autoimmune diseases, and its use during pregnancy and lactation is a debated topic.

[1]  G. Moro,et al.  A new formula for premature infants: effects on growth and nutritional status , 2015, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[2]  Z. Hrnčíř,et al.  Extended follow-up of the CYCLOFA-LUNE trial comparing two sequential induction and maintenance treatment regimens for proliferative lupus nephritis based either on cyclophosphamide or on cyclosporine A , 2014, Lupus.

[3]  F. Förger,et al.  How safe are anti-rheumatic drugs during pregnancy? , 2013, Current opinion in pharmacology.

[4]  Q. Fu,et al.  Cyclosporine A promotes in vitro migration of human first-trimester trophoblasts via MAPK/ERK1/2-mediated NF-κB and Ca2+/calcineurin/NFAT signaling. , 2013, Placenta.

[5]  M. Moritz,et al.  Ciclosporin Use During Pregnancy , 2013, Drug Safety.

[6]  C. Oddis,et al.  Therapeutic advances in myositis , 2012, Current opinion in rheumatology.

[7]  Angela Tincani,et al.  Pregnancy implications for systemic lupus erythematosus and the antiphospholipid syndrome. , 2012, Journal of autoimmunity.

[8]  E. Ammirati,et al.  Cyclosporine in transplantation - a history of converging timelines. , 2011, Journal of biological regulators and homeostatic agents.

[9]  J. Bisognano,et al.  Hypertension in pregnancy and women of childbearing age. , 2009, The American journal of medicine.

[10]  Lelia Duley,et al.  The global impact of pre-eclampsia and eclampsia. , 2009, Seminars in perinatology.

[11]  J. Pope,et al.  Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) is Improving: Results from a Case Control Study and Literature Review , 2008, The open rheumatology journal.

[12]  A. Tincani,et al.  Follow-up of children exposed antenatally to immunosuppressive drugs. , 2008, Rheumatology.

[13]  Marcus John Beasley,et al.  Immune function in children born to mothers with autoimmune diseases and exposed in utero to immunosuppressants , 2007, Lupus.

[14]  Wen-hui Zhou,et al.  Cyclosporin A Improves Pregnancy Outcome by Promoting Functions of Trophoblasts and Inducing Maternal Tolerance to the Allogeneic Fetus in Abortion-Prone Matings in the Mouse1 , 2007, Biology of reproduction.

[15]  V. Khajuria,et al.  Pregnancy and rheumatoid arthritis. , 2006, Indian journal of medical sciences.

[16]  Y. Shoenfeld,et al.  International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) , 2006, Journal of thrombosis and haemostasis : JTH.

[17]  M. Piepenbrink,et al.  Developmental immunotoxicity of cyclosporin-A in rats: age-associated differential effects. , 2005, Toxicology.

[18]  S. Decramer,et al.  Long-term effects of in utero exposure to cyclosporin A on renal function in the rabbit. , 2004, Journal of the American Society of Nephrology : JASN.

[19]  G. Koren,et al.  Cyclosporine excretion into breast milk. , 2003, Transplantation.

[20]  M. Moritz,et al.  Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation. , 2003, Clinical transplants.

[21]  A. Tincani,et al.  The immune development in a child born to a cyclosporin A-treated woman with systemic lupus erythematosus/polymyositis , 2002, Lupus.

[22]  R. Zinkernagel Maternal antibodies, childhood infections, and autoimmune diseases. , 2001, The New England journal of medicine.

[23]  T. Kveder,et al.  Anticardiolipin and anti-beta(2) glycoprotein I antibodies in sera of 61 apparently healthy children at regular preventive visits. , 2001, Rheumatology.

[24]  T. Einarson,et al.  Pregnancy outcome after cyclosporine therapy during pregnancy: a meta-analysis. , 2001, Transplantation.

[25]  G. Stallone,et al.  Immunologic evaluation during the first year of life of infants born to cyclosporine-treated female kidney transplant recipients: analysis of lymphocyte subpopulations and immunoglobulin serum levels. , 2000, Transplantation.

[26]  T. Cole,et al.  Growth patterns of breastfed infants in seven countries , 2000, Acta paediatrica.

[27]  K. Kalunian,et al.  Assessing disease activity in SLE patients during pregnancy , 1999, Lupus.

[28]  G. Nyberg,et al.  Breast-feeding during treatment with cyclosporine. , 1998, Transplantation.

[29]  J. Kalden,et al.  Cyclosporin A in the treatment of systemic lupus erythematosus: results of an open clinical study. , 1996, British journal of rheumatology.

[30]  L. Fedele,et al.  Weight at birth by gestational age in Italy. , 1995, Human reproduction.

[31]  H. Nishida,et al.  SEVERE B CELL DEPLETION IN NEWBORNS FROM RENAL TRANSPLANT MOTHERS TAKING IMMUNOSUPPRESSIVE AGENTS , 1994, Transplantation.

[32]  A. Olshan,et al.  International Commission for Protection Against Environmental Mutagens and Carcinogens. Cyclosporine A: review of genotoxicity and potential for adverse human reproductive and developmental effects. Report of a Working Group on the genotoxicity of cyclosporine A, August 18, 1993. , 1994, Mutation research.

[33]  R. Alexander The Transfer of Drugs and Other Chemicals Into Human Milk , 1994, Pediatrics.

[34]  J. Madrenas,et al.  The mechanism of action of cyclosporine: a perspective for the 90's. , 1991, Clinical biochemistry.

[35]  T. Starzl,et al.  Cyclosporine and its metabolites in mother and baby. , 1988, Transplantation.

[36]  S. Perrone,et al.  Successful pregnancy and vaginal delivery after heart transplantation. , 1988, American journal of obstetrics and gynecology.

[37]  J. Mahony,et al.  Successful pregnancy in a renal transplant recipient taking cyclosporin A. , 1986, Australian and New Zealand journal of medicine.

[38]  A. Capute,et al.  The motor quotient. A method for the early detection of motor delay. , 1985, American journal of diseases of children.

[39]  W. Gross,et al.  Treatment of ANCA-associated vasculitis , 2014, Nature Reviews Nephrology.

[40]  Bibliographic Sources Screening for gestational diabetes mellitus: U.S. Preventive Services Task Force recommendation statement. , 2008, Annals of internal medicine.

[41]  A. Doria,et al.  Cyclosporin A in a pregnant patient affected with systemic lupus erythematosus , 2004, Rheumatology International.

[42]  M. Nandakumaran,et al.  Transfer of cyclosporine in the perfused human placenta. , 1990, Developmental pharmacology and therapeutics.

[43]  S. Flechner,et al.  The presence of cyclosporine in body tissues and fluids during pregnancy. , 1985, American journal of kidney diseases : the official journal of the National Kidney Foundation.