Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease

To characterize the diversity and taxonomic relative abundance of the gut microbiota in patients with never‐treated, recent‐onset psoriatic arthritis (PsA).

[1]  W. Garrett,et al.  The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis , 2013, Science.

[2]  Dafna Gladman,et al.  Classification criteria for psoriatic arthritis: development of new criteria from a large international study. , 2006, Arthritis and rheumatism.

[3]  M. De Vos,et al.  Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model , 2012, Annals of the rheumatic diseases.

[4]  Michael A McGuckin,et al.  Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria , 2010, The American Journal of Gastroenterology.

[5]  T. Mcclanahan,et al.  IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells , 2012, Nature Medicine.

[6]  A. Rizzo,et al.  Interleukin-22 and interleukin-22-producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis. , 2012, Arthritis and rheumatism.

[7]  B. Vainer,et al.  Rectal dialysate and fecal concentrations of neutrophil gelatinase-associated lipocalin, interleukin-8, and tumor necrosis factor-α in ulcerative colitis , 1999, American Journal of Gastroenterology.

[8]  A. Viale,et al.  Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. , 2012, Arthritis and rheumatism.

[9]  Vinod Chandran,et al.  Soluble biomarkers differentiate patients with psoriatic arthritis from those with psoriasis without arthritis. , 2010, Rheumatology.

[10]  W. M. Vos,et al.  Intestinal Integrity and Akkermansia muciniphila, a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly , 2007, Applied and Environmental Microbiology.

[11]  H. Vogel,et al.  Probiotic Bacteria Produce Conjugated Linoleic Acid Locally in the Gut That Targets Macrophage PPAR γ to Suppress Colitis , 2012, PloS one.

[12]  D. Jewell,et al.  Peripheral arthropathies in inflammatory bowel disease: their articular distribution and natural history , 1998, Gut.

[13]  P. Rutgeerts,et al.  Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD , 2014, Gut.

[14]  C. Huttenhower,et al.  Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis , 2013, eLife.

[15]  Xiaoxia Zhu,et al.  Adipokines in Psoriatic Arthritis Patients: The Correlations with Osteoclast Precursors and Bone Erosions , 2012, PloS one.

[16]  Timothy L. Tickle,et al.  Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment , 2012, Genome Biology.

[17]  J. Reveille,et al.  Genetics of spondyloarthritis—beyond the MHC , 2012, Nature Reviews Rheumatology.

[18]  F. D'armiento,et al.  Microscopic inflammatory changes in colon of patients with both active psoriasis and psoriatic arthritis without bowel symptoms. , 2000, The Journal of rheumatology.

[19]  C. Manichanh,et al.  Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach , 2005, Gut.

[20]  R. Bloomfeld,et al.  Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease. , 2012, Clinical nutrition.

[21]  Marco Scutari,et al.  Learning Bayesian Networks with the bnlearn R Package , 2009, 0908.3817.

[22]  M. Brown,et al.  β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice. , 2012, Arthritis and rheumatism.

[23]  Leandro Martínez,et al.  Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists , 2012, PloS one.

[24]  H. Tilg,et al.  The RANKL/OPG system is activated in inflammatory bowel disease and relates to the state of bone loss , 2005, Gut.

[25]  S. Bull,et al.  Human leucocyte antigen risk alleles for psoriatic arthritis among patients with psoriasis , 2011, Annals of the rheumatic diseases.

[26]  E. Schwarz,et al.  RANKL induces heterogeneous DC‐STAMPlo and DC‐STAMPhi osteoclast precursors of which the DC‐STAMPlo precursors are the master fusogens , 2009, Journal of cellular physiology.

[27]  P. Vandamme,et al.  Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives , 2011, Gut.

[28]  M. De Vos,et al.  The evolution of spondyloarthropathies in relation to gut histology. II. Histological aspects. , 1995, The Journal of rheumatology.

[29]  H. Kiyono,et al.  RANKL Is Necessary and Sufficient to Initiate Development of Antigen-Sampling M Cells in the Intestinal Epithelium1 , 2009, The Journal of Immunology.

[30]  F. Guarner,et al.  Phylogenetic Analysis of Dysbiosis in Ulcerative Colitis During Remission , 2013, Inflammatory bowel diseases.

[31]  J. Doré,et al.  Comparison of the faecal microflora of patients with ankylosing spondylitis and controls using molecular methods of analysis. , 2002, Rheumatology.

[32]  Anders F. Andersson,et al.  A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. , 2010, Gastroenterology.

[33]  F. Toberer,et al.  Tissue microarray analysis of RANKL in cutaneous lupus erythematosus and psoriasis , 2011, Experimental dermatology.

[34]  Richard A. Flavell,et al.  NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis , 2011, Cell.

[35]  James A. Foster,et al.  Phylogenetics Clearcut : a fast implementation of relaxed neighbor joining , 2006 .

[36]  A. Qureshi,et al.  Psoriasis, psoriatic arthritis and increased risk of incident Crohn's disease in US women , 2012, Annals of the rheumatic diseases.

[37]  P. Bork,et al.  Enterotypes of the human gut microbiome , 2011, Nature.

[38]  D. Elewaut,et al.  Mucosal Inflammation in Spondylarthritides: Past, Present, and Future , 2011, Current rheumatology reports.

[39]  D. Cua,et al.  Autoimmunity's collateral damage: Gut microbiota strikes 'back' , 2011, Nature Medicine.

[40]  R. Winchester,et al.  HLA associations reveal genetic heterogeneity in psoriatic arthritis and in the psoriasis phenotype. , 2012, Arthritis and rheumatism.

[41]  T. R. Licht,et al.  Gram-negative bacteria account for main differences between faecal microbiota from patients with ulcerative colitis and healthy controls. , 2012, Beneficial microbes.

[42]  E. Schwarz,et al.  Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. , 2003, The Journal of clinical investigation.

[43]  Ben Lacy Costello,et al.  The FASEB Journal • Research Communication Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease , 2022 .

[44]  C. Huttenhower,et al.  Metagenomic biomarker discovery and explanation , 2011, Genome Biology.

[45]  R. Hammer,et al.  Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. , 1996, The Journal of clinical investigation.