Paramagnetic gold nanostructures for dual modal bioimaging and phototherapy of cancer cells.

Paramagnetic gold nanostructures were synthesized by combining the paramagnetism of gadolinium with the plasmonic properties of gold nanoparticles and used for dual modal (MRI and optical) imaging and phototherapy of breast cancer cells.

[1]  Jeff W M Bulte,et al.  Iron oxide MR contrast agents for molecular and cellular imaging , 2004, NMR in biomedicine.

[2]  Atle Bjørnerud,et al.  The utility of superparamagnetic contrast agents in MRI: theoretical consideration and applications in the cardiovascular system , 2004, NMR in biomedicine.

[3]  Vladimir P Zharov,et al.  Photothermal nanotherapeutics and nanodiagnostics for selective killing of bacteria targeted with gold nanoparticles. , 2006, Biophysical journal.

[4]  Jin Kyeong Kim,et al.  Direct immobilization of protein g variants with various numbers of cysteine residues on a gold surface. , 2007, Analytical chemistry.

[5]  R. Weissleder A clearer vision for in vivo imaging , 2001, Nature Biotechnology.

[6]  Kent Kirshenbaum,et al.  Viral nanoparticles donning a paramagnetic coat: conjugation of MRI contrast agents to the MS2 capsid. , 2006, Nano letters.

[7]  Konstantin V Sokolov,et al.  Hybrid plasmonic magnetic nanoparticles as molecular specific agents for MRI/optical imaging and photothermal therapy of cancer cells , 2007 .

[8]  Chun Li,et al.  Bifunctional Gold Nanoshells with a Superparamagnetic Iron Oxide-Silica Core Suitable for Both MR Imaging and Photothermal Therapy. , 2007, The journal of physical chemistry. C, Nanomaterials and interfaces.

[9]  Xiaohua Huang,et al.  Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. , 2006, Journal of the American Chemical Society.

[10]  J. West,et al.  Immunotargeted nanoshells for integrated cancer imaging and therapy. , 2005, Nano letters.

[11]  Earl J. Bergey,et al.  Nanochemistry: Synthesis and Characterization of Multifunctional Nanoclinics for Biological Applications , 2002 .

[12]  R. Issels,et al.  Hyperthermia in oncology. , 2001 .

[13]  Joseph M. McLellan,et al.  Facile synthesis of gold-silver nanocages with controllable pores on the surface. , 2006, Journal of the American Chemical Society.

[14]  Taeghwan Hyeon,et al.  Designed fabrication of multifunctional magnetic gold nanoshells and their application to magnetic resonance imaging and photothermal therapy. , 2006, Angewandte Chemie.

[15]  Klaas Nicolay,et al.  Annexin A5-conjugated quantum dots with a paramagnetic lipidic coating for the multimodal detection of apoptotic cells. , 2006, Bioconjugate chemistry.

[16]  H. Hofmann,et al.  Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system , 2005 .

[17]  J. Frangioni In vivo near-infrared fluorescence imaging. , 2003, Current opinion in chemical biology.

[18]  P. Wust,et al.  The cellular and molecular basis of hyperthermia. , 2002, Critical reviews in oncology/hematology.

[19]  B. Bonnemain,et al.  Superparamagnetic agents in magnetic resonance imaging: physicochemical characteristics and clinical applications. A review. , 1998, Journal of drug targeting.

[20]  Younan Xia,et al.  Gold Nanocages: Engineering Their Structure for Biomedical Applications , 2005 .

[21]  T. Hirano,et al.  Nanogel-quantum dot hybrid nanoparticles for live cell imaging. , 2005, Biochemical and biophysical research communications.

[22]  R. Stafford,et al.  Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance , 2003, Proceedings of the National Academy of Sciences of the United States of America.