Alkaloids from Ochrosia borbonica

Ten new monoterpenoid indole alkaloids, ochroborines A and B (1 and 2, resp.), 10-hydroxyisovallesiachotamine (3), 10-hydroxyisositsirikine (4), 10,11-dimethoxysitsirikine (5), 10-methoxyapoyohimbine (6), 10-hydroxyakuammidine (7), akuammidine 17-O--D-glucoside (8), 15-hydroxyapparicine (9), and 15-hydroxy-10-methoxyapparicine (10), and 24 known alkaloids were isolated from leaves and twigs of Ochrosia borbonica J.F.Gmel. These structures were elucidated based on 1D- and 2D-NMR, FT-IR, UV, and MS data. 10-Hydroxyisovallesiachotamine (3), ellipticine, and 10-methoxyellipticine showed cytotoxic activities against five human cancer cell lines.

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