Use of the z‐transform to investigate nanopulse penetration of biological matter

Short duration, fast rise time electromagnetic ultra-wideband (UWB) pulses ("nanopulses") are generated by numerous electronic devices. Many new technologies involving nanopulses are under development and expected to become widely available soon. Study of nanopulse bioeffects therefore is needed to ensure human safety and to probe the useful range of nanopulses in possible biomedical and biotechnological applications. In this article, we present a new approximation of the Cole-Cole expression for the frequency dependence of the dielectric properties of tissues. The approximation is based on a z-transformation of the electric displacement and a second-order Taylor approximation of the Cole-Cole expression. The approach has been applied to investigating the penetration of nanopulses into biological matter as a function of the dielectric properties of tissue and pulse width. Solutions to Maxwell's equations are calculated using the finite difference time domain method (FDTD).

[1]  K.W. Leung,et al.  A circularly polarized dielectric resonator antenna excited by an asymmetrical U-slot with a backing cavity , 2003, IEEE Antennas and Wireless Propagation Letters.

[2]  R. W. Lau,et al.  The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. , 1996, Physics in medicine and biology.

[3]  C Gabriel,et al.  The dielectric properties of biological tissues: I. Literature survey. , 1996, Physics in medicine and biology.

[4]  R. Luebbers,et al.  The Finite Difference Time Domain Method for Electromagnetics , 1993 .

[5]  R. W. Lau,et al.  The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues. , 1996, Physics in medicine and biology.

[6]  Dennis M. Sullivan,et al.  Electromagnetic Simulation Using the FDTD Method , 2000 .

[7]  J. Bérenger Three-Dimensional Perfectly Matched Layer for the Absorption of Electromagnetic Waves , 1996 .

[8]  Laura Marcu,et al.  Nanoelectropulse-induced phosphatidylserine translocation. , 2004, Biophysical journal.

[9]  K. Cole,et al.  Dispersion and Absorption in Dielectrics I. Alternating Current Characteristics , 1941 .

[10]  Neven Simicevic,et al.  FDTD simulation of exposure of biological material to electromagnetic nanopulses , 2004, Physics in medicine and biology.

[11]  James C. Lin Electromagnetic Pulse Interaction with Mammalian Cranial Structures , 1976, IEEE Transactions on Biomedical Engineering.

[12]  K. Schoenbach,et al.  Mechanism for membrane electroporation irreversibility under high-intensity, ultrashort electrical pulse conditions. , 2002, Physical review. E, Statistical, nonlinear, and soft matter physics.

[13]  Matthew N. O. Sadiku,et al.  Numerical Techniques in Electromagnetics , 2000 .

[14]  Todd A. Kuiken,et al.  Finite-element time-domain algorithms for modeling linear Debye and Lorentz dielectric dispersions at low frequencies , 2003, IEEE Transactions on Biomedical Engineering.

[15]  K. Schoenbach,et al.  Self-consistent simulations of electroporation dynamics in biological cells subjected to ultrashort electrical pulses. , 2001, Physical review. E, Statistical, nonlinear, and soft matter physics.

[16]  Kenneth R. Foster,et al.  Thermal and nonthermal mechanisms of interaction of radio-frequency energy with biological systems , 2000 .

[17]  S.C. Hagness,et al.  Numerical and experimental investigation of an ultrawideband ridged pyramidal horn antenna with curved launching plane for pulse radiation , 2003, IEEE Antennas and Wireless Propagation Letters.

[18]  Jean-Pierre Berenger,et al.  A perfectly matched layer for the absorption of electromagnetic waves , 1994 .

[19]  William D. Hurt,et al.  Multiterm Debye Dispersion Relations for Permittivity of Muscle , 1985, IEEE Transactions on Biomedical Engineering.

[20]  K. Yee Numerical solution of initial boundary value problems involving maxwell's equations in isotropic media , 1966 .

[21]  H. F. Cook,et al.  The dielectric behaviour of some types of human tissues at microwave frequencies , 1951 .

[22]  K. Foster,et al.  Dielectric properties of tissues and biological materials: a critical review. , 1989, Critical reviews in biomedical engineering.

[23]  K. Schoenbach,et al.  Intracellular effect of ultrashort electrical pulses , 2001, Bioelectromagnetics.

[24]  James C Lin Interaction of Electromagnetic Transient Radiation with Biological Materials , 1975, IEEE Transactions on Electromagnetic Compatibility.

[25]  Allen Taflove,et al.  Computational Electrodynamics the Finite-Difference Time-Domain Method , 1995 .

[26]  K. Schoenbach,et al.  Electroporation dynamics in biological cells subjected to ultrafast electrical pulses: a numerical simulation study. , 2000, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.