RNA interference as potential therapy--not so fast.
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RNA interference has been successfully used to treat several animal models of human disease, giving hope that this approach may have therapeutic potential. A new study shows, however, that the appr...
[1] Theresa A. Storm,et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways , 2006, Nature.
[2] G. Hannon,et al. Control of translation and mRNA degradation by miRNAs and siRNAs. , 2006, Genes & development.
[3] C. Burge,et al. Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets , 2005, Cell.
[4] A. Fire,et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans , 1998, Nature.