Association between Genetic Polymorphism of Tumor Necrosis Factor-a and Risk of Oral Submucous Fibrosis, a Pre-cancerous Condition of Oral Cancer

Many cytokines have been thought to play important roles in the pathogenesis of oral submucous fibrosis (OSF), an areca nut chewing-specific pre-cancerous condition characterized by the deposition of collagen in oral submucosa. Tumor necrosis factor-a (TNF-a), situated in the class III region of human leukocyte antigen (HLA), is a mediator with multiple functions, including the regulation of inflammatory reaction and transcriptions of collagen and collagenase. In total, 809 male subjects were recruited for assessment of the association of OSF with a bi-allelic promoter-region (-308) polymorphism on the TNFA gene. The high production allele, TNF2, was significantly lower among OSF subjects (n = 166) than in areca-chewing controls (n = 284). This association was independent of oral cancer status. The multivariate-adjusted odds ratio for the TNFA 11 genotype was 2.6 (95% confidence interval = 1.4-4.9 ; p = 0.004). The finding may imply a multifunctional etiological factor of TNF-α in OSF pathogenesis.

[1]  S. Meghji,et al.  Interferon gamma (IFN-gamma) may reverse oral submucous fibrosis. , 2001, Journal of Oral Pathology & Medicine.

[2]  S. Meghji,et al.  Oral submucous fibrosis patients have altered levels of cytokine production. , 2000, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[3]  N. Camp,et al.  Primary biliary cirrhosis shows association with genetic polymorphism of tumour necrosis factor alpha promoter region. , 1999, Journal of hepatology.

[4]  J. Hull,et al.  Contribution of genetic factors other than CFTR to disease severity in cystic fibrosis , 1998, Thorax.

[5]  P. Borm,et al.  Polymorphisms in the promoter of the tumor necrosis factor-alpha gene in coal miners. , 1998, American journal of industrial medicine.

[6]  S. Meghji,et al.  Immunolocalization of cytokines and growth factors in oral submucous fibrosis. , 1998, Cytokine.

[7]  P. Gupta,et al.  Oral submucous fibrosis in India: a new epidemic? , 1998, The National medical journal of India.

[8]  Song-Lih Huang,et al.  Tumor Necrosis Factor- α Gene Polymorphism in Chronic Bronchitis , 1997 .

[9]  I A Razak,et al.  A national epidemiological survey of oral mucosal lesions in Malaysia. , 1997, Community dentistry and oral epidemiology.

[10]  T. Peters,et al.  Copper content in Areca catechu (betel nut) products and oral submucous fibrosis , 1997, The Lancet.

[11]  S. Meghji,et al.  HLA-typing in oral submucous fibrosis. , 1997 .

[12]  H. Mcdevitt,et al.  Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[13]  T. Ling,et al.  Epidemiological survey of oral submucous fibrosis in Xiangtan City, Hunan Province, China. , 1997, Community dentistry and oral epidemiology.

[14]  P. Speight,et al.  An immunohistochemical study of oral submucous fibrosis. , 1997, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[15]  D. Kwiatkowski,et al.  Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria , 1994, Nature.

[16]  R. Armitage.  Tumor necrosis factor receptor superfamily members and their ligands. , 1994, Current opinion in immunology.

[17]  J A Lewis,et al.  Role of areca nut in the causation of oral submucous fibrosis: a case-control study in Pakistan. , 1994, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[18]  M. Meurer,et al.  Polymorphism of the tumor necrosis factor genes in patients with dermatitis herpetiformis. , 1994, Dermatology.

[19]  M. Hammond,et al.  HLA-antigens in oral submucous fibrosis. , 1994, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[20]  F. Pociot,et al.  An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles , 1993, The Journal of experimental medicine.

[21]  A. Blakemore,et al.  Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product. , 1992, Human molecular genetics.

[22]  Y. Ko,et al.  Prevalence of betel quid chewing habit in Taiwan and related sociodemographic factors. , 1992, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[23]  Yang Jf,et al.  Collagenase activity in oral submucous fibrosis. , 1992 .

[24]  J. F. Yang,et al.  Collagenase activity in oral submucous fibrosis. , 1992, Proceedings of the National Science Council, Republic of China. Part B, Life sciences.

[25]  P. Gupta,et al.  A case-control study of oral submucous fibrosis with special reference to the etiologic role of areca nut. , 1990, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[26]  D. Brenner,et al.  Prolonged activation of jun and collagenase genes by tumour necrosis factor-α , 1989, Nature.

[27]  H A Seedat,et al.  Betel-nut chewing and submucous fibrosis in Durban. , 1988, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[28]  D. Brenner,et al.  Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. , 1988, The Journal of biological chemistry.

[29]  B. Beutler,et al.  CACHECTIN: MORE THAN A TUMOR NECROSIS FACTOR , 1988 .

[30]  H. Orr,et al.  Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[31]  W. Harvey,et al.  Oral submucous fibrosis: its pathogenesis and management , 1986, British Dental Journal.

[32]  W. Harvey,et al.  Stimulation of human buccal mucosa fibroblasts in vitro by betel-nut alkaloids. , 1986, Archives of oral biology.

[33]  J. Pindborg,et al.  Oral Submucous Fibrosis as a Precancerous Condition , 1966 .

[34]  D. Paissat,et al.  Oral submucous fibrosis. , 1981, International journal of oral surgery.

[35]  Kwan Hw.  A statistical study on oral carcinomas in Taiwan with emphasis on the relationship with betel nut chewing: a preliminary report. , 1976 .

[36]  H. Kwan.  A statistical study on oral carcinomas in Taiwan with emphasis on the relationship with betel nut chewing: a preliminary report. , 1976, Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association.

[37]  O S Miettinen,et al.  Proportion of disease caused or prevented by a given exposure, trait or intervention. , 1974, American journal of epidemiology.