Influence of ribose donors on the action of 5-fluorouracil.

Although the most potent antimetabolite formed from 5-fluorouracil in vivo is a deoxyribonucleotide, evidence has accumulated which suggests an antineoplastic role for drug ribonucleotides. A study of the consequences of stimulating 5-fluorouracil metabolism along pathways leading to drug ribonucleotides was therefore made, using murine leukemias. Appropriate ribose donors, e.g., glucose and inosine, strongly enhanced the conversion of 5-fluorouracil to ribonucleotides, both in vitro and in vivo , but this had little effect on drug-promoted survival of tumor-bearing animals.

[1]  D. Kessel,et al.  Transport of two non-metabolized nucleosides, deoxycytidine and cytosine arabinoside, in a sub-line of the L1210 murine leukemia. , 1968, Biochimica et biophysica acta.

[2]  I. Wodinsky,et al.  Uptake in vivo and in vitro of actinomycin D by mouse leukemias as factors in survival. , 1968, Biochemical pharmacology.

[3]  D. Kessel,et al.  Studies on drug transport by normal human leukocytes. , 1967, Biochemical pharmacology.

[4]  D. Kessel,et al.  Amethopterin transport in Ehrlich ascites carcinoma and L1210 cells. , 1967, Cancer research.

[5]  K. Ibsen,et al.  Inorganic ion concentrations in Ehrlich ascites carcinoma cells and fluid. , 1967, Cancer research.

[6]  Schell Hw,et al.  5-Fluorouracil (NSC-19893) in glucose and saline: therapeutic effect and toxicity. , 1966 .

[7]  I. Wodinsky,et al.  Nucleotide Formation as a Determinant of 5-Fluorouracil Response in Mouse Leukemias , 1966, Science.

[8]  S. Perry,et al.  Pyrimidine metabolism in human leukocytes. 3. The utilization of thymine for DNA-thymine synthesis by leukemic leukocytes. , 1966, Cancer research.

[9]  A. Pardee,et al.  On the action of fluorouracil on leukemia cells. , 1966, Cancer research.

[10]  C. Griffiths,et al.  Time and vehicle studies of a safe and effective method for administration of 5‐fluorouracil , 1966, Cancer.

[11]  I. Wodinsky,et al.  Studies on folic reductase. 3. The level of enzyme activity and response to methotrexate of transplantable mouse tumors. , 1965, Cancer research.

[12]  Henderson Jf,et al.  AVAILABILITY OF 5-PHOSPHORIBOSYL 1-PYROPHOSPHATE FOR RIBONUCLEOTIDE SYNTHESIS IN EHRLICH ASCITES TUMOR CELLS IN VITRO. , 1965 .

[13]  J. L. Dahl,et al.  Potentiation of 5-Fluorouracil Inhibition of Flexner-Jobling Carcinoma by Glucose , 1963, Science.

[14]  D. M. Greenberg,et al.  STUDIES ON TUMOR RESISTANCE TO 5-FLUOROURACIL. , 1963, Cancer research.

[15]  J. Jacquez.  Transport and enzymic splitting of pyrimidine nucleosides in Ehrlich cells. , 1962, Biochimica et biophysica acta.

[16]  P. Reichard,et al.  Studies on resistance against 5-fluorouracil. I. Enzymes of the uracil pathway during development of resistance. , 1962, Cancer research.

[17]  J. Jacquez.  Permeability of Ehrlich Cells to Uracil, Thymine and Fluorouracil.∗ , 1962, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[18]  C. Heidelberger,et al.  Studies on fluorinated pyrimidines. XIII. Inhibition of thymidylate synthetase. , 1961, The Journal of biological chemistry.

[19]  D. Burk,et al.  Glucose enhancement of inhibition by fluorinated and normal pyrimi- dines of tumor glycolysis and transplantability. Abstr. , 1960 .

[20]  G. Ricceri,et al.  The nucleic acid metabolism of animal cells in vitro. III. Factors influencing nucleotide biosynthesis. , 1960, Biochimica et biophysica acta.

[21]  C. Heidelberger,et al.  Studies on fluorinated pyrimidines. VIII. Further biochemical and metabolic investigations. , 1959, The Journal of biological chemistry.

[22]  G. Klein,et al.  Possible Enzymic Mechanism for the Development of Resistance against Fluorouracil in Ascites Tumours , 1959, Nature.

[23]  Seymour S. Cohen,et al.  THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES. , 1958, Proceedings of the National Academy of Sciences of the United States of America.

[24]  J. Davidson,et al.  The nucleic acid metabolism of animal cells in vitro. I. The incorporation of 14C-formate. , 1958, Biochimica et biophysica acta.

[25]  C. Heidelberger,et al.  Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo. , 1958, Cancer research.

[26]  C. Heidelberger,et al.  Studies on fluorinated pyrimidines. IV. Effects on nucleic acid metabolism in vivo. , 1958, Cancer research.

[27]  C. Heidelberger,et al.  Studies on fluorinated pyrimidines. II. Effects on transplanted tumors. , 1958, Cancer research.