Naringenin Promotes Thermogenic Gene Expression in Human White Adipose Tissue

Naringenin, a citrus flavonoid, prevents diet‐induced weight gain and improves glucose and lipid metabolism in rodents. There is evidence that naringenin activates brown fat and increases energy expenditure in mice, but little is known about its effects in humans. The goal of this study was to examine the effects of naringenin on energy expenditure in adipose tissue.

[1]  F. Greenway,et al.  Fucoxanthin and Its Metabolite Fucoxanthinol Do Not Induce Browning in Human Adipocytes. , 2017, Journal of agricultural and food chemistry.

[2]  D. Ndwandwe,et al.  Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights. , 2017, European journal of pharmacology.

[3]  Eran Segal,et al.  Persistent microbiome alterations modulate the rate of post-dieting weight regain , 2016, Nature.

[4]  C. Diéguez,et al.  Antiobesity efficacy of GLP-1 receptor agonist liraglutide is associated with peripheral tissue-specific modulation of lipid metabolic regulators. , 2016, BioFactors.

[5]  M. Huff,et al.  Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis. , 2016, Annual review of nutrition.

[6]  H. Guillou,et al.  White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways , 2016, Molecular metabolism.

[7]  L. Chan,et al.  FABP4-Cre Mediated Expression of Constitutively Active ChREBP Protects Against Obesity, Fatty Liver, and Insulin Resistance. , 2015, Endocrinology.

[8]  S. Mandrup,et al.  Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers , 2015, Genes & development.

[9]  M. Klingenspor,et al.  Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes , 2014, EMBO reports.

[10]  Alan D. Lopez,et al.  Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013 , 2014, The Lancet.

[11]  Clark R. Andersen,et al.  Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans , 2014, Diabetes.

[12]  J. F. Young,et al.  Caffeic acid, naringenin and quercetin enhance glucose‐stimulated insulin secretion and glucose sensitivity in INS‐1E cells , 2014, Diabetes, obesity & metabolism.

[13]  P. Seale,et al.  Brown and beige fat: development, function and therapeutic potential , 2013, Nature Medicine.

[14]  U. Knippschild,et al.  De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health , 2013, Nature Communications.

[15]  G. Shulman,et al.  Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes , 2013, Diabetes.

[16]  M. Blüher,et al.  A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism , 2012, Nature.

[17]  G. Ailhaud,et al.  Differentiation of Human Adipose-Derived Stem Cells into “Brite” (Brown-in-White) Adipocytes , 2011, Front. Endocrin..

[18]  A. Landar,et al.  Assessing bioenergetic function in response to oxidative stress by metabolic profiling. , 2011, Free radical biology & medicine.

[19]  Christopher J. Lyon,et al.  A Peroxisome Proliferator-activated Receptor γ (PPARγ)/PPARγ Coactivator 1β Autoregulatory Loop in Adipocyte Mitochondrial Function* , 2011, The Journal of Biological Chemistry.

[20]  A. Carpentier,et al.  Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. , 2011, The Journal of clinical endocrinology and metabolism.

[21]  M. Yarmush,et al.  Transcriptional Regulation of Human and Rat Hepatic Lipid Metabolism by the Grapefruit Flavonoid Naringenin: Role of PPARα, PPARγ and LXRα , 2010, PloS one.

[22]  Naresh Kumar,et al.  Acute Stimulation of White Adipocyte Respiration by PKA-Induced Lipolysis , 2010, Diabetes.

[23]  B. Faubert,et al.  Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK. , 2010, Biochemical and biophysical research communications.

[24]  S. Kannappan,et al.  Naringenin enhances insulin-stimulated tyrosine phosphorylation and improves the cellular actions of insulin in a dietary model of metabolic syndrome , 2010, European journal of nutrition.

[25]  M. Lorenzo,et al.  Adenosine 5'-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte differentiation. , 2010, Endocrinology.

[26]  K. Kristiansen,et al.  Human Multipotent Adipose‐Derived Stem Cells Differentiate into Functional Brown Adipocytes , 2009, Stem cells.

[27]  R. Hegele,et al.  Naringenin Prevents Dyslipidemia, Apolipoprotein B Overproduction, and Hyperinsulinemia in LDL Receptor–Null Mice With Diet-Induced Insulin Resistance , 2009, Diabetes.

[28]  R. Scarpulla Transcriptional paradigms in mammalian mitochondrial biogenesis and function. , 2008, Physiological reviews.

[29]  S. Z. Imam,et al.  Medicinal importance of grapefruit juice and its interaction with various drugs , 2007, Nutrition journal.

[30]  I. Niopas,et al.  Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects , 2007, European Journal of Clinical Nutrition.

[31]  Frank Eisenhaber,et al.  Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase , 2004, Science.

[32]  M. Matsuda,et al.  Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. , 2003, Diabetes.

[33]  G. Shulman,et al.  AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[34]  S. O’Rahilly,et al.  Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPARγ Agonists: A Potential Mechanism of Insulin Sensitization. , 2002, Endocrinology.

[35]  P. Ho,et al.  Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds. , 2001, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[36]  M. Reitman,et al.  Lipoatrophy syndromes: when ‘too little fat’ is a clinical problem , 2000, Pediatric diabetes.

[37]  D. Bailey,et al.  Grapefruit juice—felodipine interaction: Effect of naringin and 6′,7′‐dihydroxybergamottin in humans , 1998, Clinical pharmacology and therapeutics.

[38]  D. Edwards,et al.  Naringin and naringenin are not the primary CYP3A inhibitors in grapefruit juice. , 1996, Life sciences.

[39]  K. Pietiläinen,et al.  Adipose tissue NAD+-homeostasis, sirtuins and poly(ADP-ribose) polymerases -important players in mitochondrial metabolism and metabolic health. , 2017, Redox biology.

[40]  S. O’Rahilly,et al.  Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. , 2002, Endocrinology.