A longitudinal study of pain sensitivity and blood pressure in adolescent boys: results from a 5-year follow-up.

A growing literature has observed a significant reduction in pain sensitivity among hypertensive animals and humans. It is uncertain whether a reduced sensitivity to pain can be observed in nonnotensive individuals who go on to develop high blood pressure. Blood pressure (BP) was reassessed in one hundred fifteen 19-year-old boys initially tested at age 14, when they were also presented with a pain stimulus (mechanical finger pressure). Hierarchical regression analyses indicated that information regarding pain tolerance improved prediction of changes in systolic and diastolic blood pressure beyond that afforded by differences in BP at age 14, parental history of hypertension, and body mass index. These analyses suggest that pain sensitivity may be associated with physiological processes involved in the development of sustained high blood pressure.

[1]  B. Ditto,et al.  Exaggeration of blood pressure-related hypoalgesia and reduction of blood pressure with low frequency transcutaneous electrical nerve stimulation. , 2002, Psychophysiology.

[2]  A. Grandi,et al.  Relationship between dental pain perception and 24 hour ambulatory blood pressure: a study on 181 subjects. , 1999, Journal of hypertension.

[3]  A. Grandi,et al.  Treatment with enalapril modifies the pain perception pattern in hypertensive patients. , 1998, Hypertension.

[4]  R. Pihl,et al.  Risk for hypertension and pain sensitivity in adolescent boys. , 1998, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[5]  D. Sheffield,et al.  The relationship between resting systolic blood pressure and cutaneous pain perception in cardiac patients with angina pectoris and controls , 1997, Pain.

[6]  C. France,et al.  Resting systolic blood pressure, parental history of hypertension, and sensitivity to noxious stimuli , 1996, Pain.

[7]  M. al’Absi,et al.  Pain perception and cardiovascular responses in men with positive parental history for hypertension. , 1996, Psychophysiology.

[8]  B. Ditto,et al.  Risk for High Blood Pressure and Decreased Pain Perception , 1996 .

[9]  W. Maixner,et al.  The Influence of Resting Blood Pressure and Gender on Pain Responses , 1996, Psychosomatic medicine.

[10]  R. Pihl,et al.  Cognitive and neuropsychological characteristics of physically aggressive boys. , 1995, Journal of abnormal psychology.

[11]  C. France,et al.  Parental history of hypertension and enhanced cardiovascular reactivity are associated with decreased pain ratings. , 1995, Psychophysiology.

[12]  S. Srinivasan,et al.  Essential hypertension predicted by tracking of elevated blood pressure from childhood to adulthood: the Bogalusa Heart Study. , 1995, American journal of hypertension.

[13]  A. Grandi,et al.  Twenty-four-hour noninvasive blood pressure monitoring and pain perception. , 1995, Hypertension.

[14]  H. Rau,et al.  Behavioral and psychophysiological predictors of self-monitored 19 month blood pressure change in normotensives. , 1994, Journal of psychosomatic research.

[15]  N. Birbaumer,et al.  Effects of PRES baroreceptor stimulation on thermal and mechanical pain threshold in borderline hypertensives and normotensives. , 1994, Psychophysiology.

[16]  N Birbaumer,et al.  Central effects of baroreceptor activation in humans: attenuation of skeletal reflexes and pain perception. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[17]  S. Bruehl,et al.  Do endogenous opioids mediate the relationship between blood pressure and pain sensitivity in normotensives? , 1994, Pain.

[18]  M. Greenlee,et al.  Baroreceptor stimulation: Pain perception and sensory thresholds , 1994, Biological Psychology.

[19]  S. Ghione,et al.  Relationship between increased blood pressure and hypoalgesia: additional evidence for the existence of an abnormality of pain perception in arterial hypertension in humans. , 1994, Journal of human hypertension.

[20]  B. Ditto,et al.  Family history of hypertension and pain during blood donation. , 1994, Psychosomatic medicine.

[21]  W. Maixner,et al.  Relation between systemic hypertension and pain perception. , 1992, The American journal of cardiology.

[22]  S. Bruehl,et al.  The relationship between pain sensitivity and blood pressure in normotensives , 1992, Pain.

[23]  Richard E. Tremblay,et al.  Disruptive boys with stable and unstable high fighting behavior patterns during junior elementary school , 1991, Journal of abnormal child psychology.

[24]  S. Ghione,et al.  Arterial Hypertension Is Associated with Hypalgesia in Humans , 1988, Hypertension.

[25]  K. Zahka.  Report of the Second Task Force on Blood Pressure Control in Children. , 1987, Maryland medical journal.

[26]  M. Horan.  Report of the Second Task Force on Blood Pressure Control in Children--1987. Task Force on Blood Pressure Control in Children. National Heart, Lung, and Blood Institute, Bethesda, Maryland. , 1987, Pediatrics.

[27]  A. Randich,et al.  Activation of the sinoaortic baroreceptor reflex arc induces analgesia: Interactions between cardiovascular and endogenous pain inhibition systems , 1983 .

[28]  W. Maixner,et al.  Factors influencing the altered pain perception in the spontaneously hypertensive rat , 1982, Brain Research.

[29]  B. Bennett,et al.  The occurrence of analgesia in an animal model of hypertension. , 1981, Life sciences.

[30]  J. Saavedra.  Naloxone reversible decrease in pain sensitivity in young and adult spontaneously hypertensive rats , 1981, Brain Research.

[31]  N. Zamir,et al.  Altered pain perception in hypertensive humans , 1980, Brain Research.

[32]  N. Miller,et al.  Baroreceptor activation reduces reactivity to noxious stimulation: implications for hypertension. , 1979, Science.

[33]  D. Moskowitz,et al.  Risk for hypertension and diminished pain sensitivity in women: autonomic and daily correlates. , 1999, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[34]  B. Ditto,et al.  Risk for hypertension and pain sensitivity in women. , 1997, International journal of behavioral medicine.

[35]  W. Maixner,et al.  Blood pressure, gender, and parental hypertension are factors in baseline and poststress pain sensitivity in normotensive adults , 1997, International journal of behavioral medicine.

[36]  T. Elbert,et al.  Sensory effects of baroreceptor activation and perceived stress together predict long-term blood pressure elevations , 1994, International journal of behavioral medicine.

[37]  J. McCubbin.  21 – Diminished Opioid Inhibition of Blood Pressure and Pituitary Function in Hypertension Development , 1991 .

[38]  C. Nemeroff,et al.  Stress, Neuropeptides, and Systemic Disease , 1991 .

[39]  W. de Jong,et al.  Observations on pain perception and hypertension in spontaneously hypertensive rats. , 1984, Clinical and experimental hypertension. Part A, Theory and practice.

[40]  T. Barber,et al.  A strain gauge pain stimulator. , 1971, Psychophysiology.

[41]  C. Spielberger,et al.  Manual for the State-Trait Anxiety Inventory , 1970 .