Personalized Hemodynamic Modeling of the Human Cardiovascular System: A Reduced-Order Computing Model

Objective: Personalization of hemodynamic modeling plays a crucial role in functional prediction of the cardiovascular system (CVS). While reduced-order models of one-dimensional (1D) blood vessel models with zero-dimensional (0D) blood vessel and heart models have been widely recognized to be an effective tool for reasonably estimating the hemodynamic functions of the whole CVS, practical personalized models are still lacking. In this paper, we present a novel 0-1D coupled, personalized hemodynamic model of the CVS that can predict both pressure waveforms and flow velocities in arteries. Methods: We proposed a methodology by combining the multiscale CVS model with the Levenberg–Marquardt optimization algorithm for effectively solving an inverse problem based on measured blood pressure waveforms. Hemodynamic characteristics including brachial arterial pressure waveforms, artery diameters, stroke volumes, and flow velocities were measured noninvasively for 62 volunteers aged from 20 to 70 years for developing and validating the model. Results: The estimated arterial stiffness shows a physiologically realistic distribution. The model-fitted individual pressure waves have an averaged mean square error (MSE) of 7.1 mmHg2; simulated blood flow velocity waveforms in carotid artery match ultrasound measurements well, achieving an average correlation coefficient of 0.911. Conclusion: The model is efficient, versatile, and capable of obtaining well-fitting individualized pressure waveforms while reasonably predicting flow waveforms. Significance: The proposed methodology of personalized hemodynamic modeling may therefore facilitate individualized patient-specific assessment of both physiological and pathological functions of the CVS.