Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design.

[1]  C. Stroh,et al.  The role of caspases in cryoinjury: caspase inhibition strongly improves the recovery of cryopreserved hematopoietic and other cells , 2002 .

[2]  R. Pope Apoptosis as a therapeutic tool in rheumatoid arthritis , 2002, Nature Reviews Immunology.

[3]  John Calvin Reed,et al.  Apoptosis-based therapies , 2002, Nature Reviews Drug Discovery.

[4]  C. Sawyers Rational therapeutic intervention in cancer: kinases as drug targets. , 2002, Current opinion in genetics & development.

[5]  R. Moritz,et al.  HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins* , 2002, The Journal of Biological Chemistry.

[6]  Yuri Lazebnik,et al.  Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction* , 2002, The Journal of Biological Chemistry.

[7]  E. Schattner Apoptosis in Lymphocytic Leukemias and Lymphomas , 2002, Cancer investigation.

[8]  J. Adams,et al.  Proteasome inhibition in cancer: development of PS-341. , 2001, Seminars in oncology.

[9]  A. Cochran,et al.  Protein-protein interfaces: mimics and inhibitors. , 2001, Current opinion in chemical biology.

[10]  M. Gleave,et al.  A phase I dose-finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[11]  P. Branton,et al.  The role of adenovirus E4orf4 protein in viral replication and cell killing , 2001, Oncogene.

[12]  I. Enyedy,et al.  Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. , 2001, Journal of medicinal chemistry.

[13]  C. Stroh,et al.  The emerging role of caspases in signal transduction as revealed by knock‐out studies − not only apoptosis , 2001 .

[14]  C. Chuong,et al.  D-RNAi (messenger RNA-antisense DNA interference) as a novel defense system against cancer and viral infections. , 2001, Current cancer drug targets.

[15]  H. Nakayama,et al.  A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. , 2001, Molecular cell.

[16]  M. Harding,et al.  ICE/Caspase-1 inhibitors as novel anti-inflammatory drugs , 2001, Expert opinion on investigational drugs.

[17]  J. Bradbury TRAIL leads to apoptosis in acute promyelocytic leukaemia , 2001, The Lancet.

[18]  L. Altucci,et al.  Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL , 2001, Nature Medicine.

[19]  G. Evan,et al.  Proliferation, cell cycle and apoptosis in cancer , 2001, Nature.

[20]  Christopher I. Bayly,et al.  Maintenance of caspase-3 proenzyme dormancy by an intrinsic “safety catch” regulatory tripeptide , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[21]  D. Vaux,et al.  Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis. , 2001, Journal of cell science.

[22]  K. Valentino,et al.  Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury. , 2001, The Journal of pharmacology and experimental therapeutics.

[23]  D. Banerjee Genasense (Genta Inc). , 2001, Current opinion in investigational drugs.

[24]  T. Tuschl,et al.  RNA Interference and Small Interfering RNAs , 2001, Chembiochem : a European journal of chemical biology.

[25]  Young Chul Park,et al.  Structural Basis of Caspase Inhibition by XIAP Differential Roles of the Linker versus the BIR Domain , 2001, Cell.

[26]  I. H. Engels,et al.  Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation , 2001, Oncogene.

[27]  A. Harken,et al.  Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1β , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[28]  D. Vaux,et al.  Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9 , 2001, The Journal of cell biology.

[29]  G M Kasof,et al.  Livin, a Novel Inhibitor of Apoptosis Protein Family Member* , 2001, The Journal of Biological Chemistry.

[30]  Stephen F. Betz,et al.  Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain , 2000, Nature.

[31]  W. Hong,et al.  Augmentation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by the synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) through up-regulation of TRAIL receptors in human lung cancer cells. , 2000, Cancer research.

[32]  K. Bhalla,et al.  Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells. , 2000, Blood.

[33]  R. Hotchkiss,et al.  Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte , 2000, Nature Immunology.

[34]  A. Strasser,et al.  The Role of the Pro‐Apoptotic Bcl‐2 Family Member Bim in Physiological Cell Death , 2000, Annals of the New York Academy of Sciences.

[35]  S. Srinivasula,et al.  Molecular Determinants of the Caspase-promoting Activity of Smac/DIABLO and Its Role in the Death Receptor Pathway* , 2000, The Journal of Biological Chemistry.

[36]  H. Jaeschke,et al.  Protection against TNF-induced liver parenchymal cell apoptosis during endotoxemia by a novel caspase inhibitor in mice. , 2000, Toxicology and applied pharmacology.

[37]  Stephen W. Fesik,et al.  NMR Structure and Mutagenesis of the Third Bir Domain of the Inhibitor of Apoptosis Protein XIAP* , 2000, The Journal of Biological Chemistry.

[38]  D. Nicholson,et al.  From bench to clinic with apoptosis-based therapeutic agents , 2000, Nature.

[39]  C. Reed,et al.  Apoptosis and cancer: strategies for integrating programmed cell death. , 2000, Seminars in hematology.

[40]  R. Lotan,et al.  Implication of multiple mechanisms in apoptosis induced by the synthetic retinoid CD437 in human prostate carcinoma cells , 2000, Oncogene.

[41]  H. Horvitz,et al.  The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone. , 2000, Molecular cell.

[42]  Xiaodong Wang,et al.  Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition , 2000, Cell.

[43]  S. Srinivasula,et al.  Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[44]  A. Hamilton,et al.  Peptide and protein recognition by designed molecules. , 2000, Chemical reviews.

[45]  M. Konopleva,et al.  Liposomal Bcl-2 antisense oligonucleotides enhance proliferation, sensitize acute myeloid leukemia to cytosine-arabinoside, and induce apoptosis independent of other antiapoptotic proteins. , 2000, Blood.

[46]  M. Piccart,et al.  The contribution of molecular markers to the prediction of response in the treatment of breast cancer: a review of the literature on HER-2, p53 and BCL-2. , 2000, Annals of oncology : official journal of the European Society for Medical Oncology.

[47]  J. Mouiel,et al.  Caspase inhibition protects from liver injury following ischemia and reperfusion in rats , 2000, Transplant international : official journal of the European Society for Organ Transplantation.

[48]  S. Strom,et al.  Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand , 2000, Nature Medicine.

[49]  G. Baxter,et al.  Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury , 2000, British journal of pharmacology.

[50]  John Calvin Reed,et al.  Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth. , 2000, Neoplasia.

[51]  J. Martinou,et al.  The Bcl-2 protein family. , 2000, Experimental cell research.

[52]  B. Evers,et al.  Sensitization of human colon cancer cells to trail-mediated apoptosis , 2000, Journal of Gastrointestinal Surgery.

[53]  A. Strasser,et al.  Apoptosis and cell division. , 2000, Current opinion in cell biology.

[54]  Fengzhi Li,et al.  Pleiotropic cell-division defects and apoptosis induced by interference with survivin function , 1999, Nature Cell Biology.

[55]  R. Flavell,et al.  Caspase knockouts: matters of life and death , 1999, Cell Death and Differentiation.

[56]  E. Slee,et al.  Serial killers: ordering caspase activation events in apoptosis , 1999, Cell Death and Differentiation.

[57]  D. Nicholson,et al.  Caspase structure, proteolytic substrates, and function during apoptotic cell death , 1999, Cell Death and Differentiation.

[58]  J C Reed,et al.  Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases , 1999, The EMBO journal.

[59]  P. Vandenabeele,et al.  Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. , 1999, The Journal of clinical investigation.

[60]  D. Lawrence,et al.  Safety and antitumor activity of recombinant soluble Apo2 ligand. , 1999, The Journal of clinical investigation.

[61]  K. Schulze-Osthoff,et al.  The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice. , 1999, Immunity.

[62]  S. Nakamura,et al.  Sensitization of AIDS-Kaposi's sarcoma cells to Apo-2 ligand-induced apoptosis by actinomycin D. , 1999, Journal of immunology.

[63]  M. Nau,et al.  Chemotherapy augments TRAIL-induced apoptosis in breast cell lines. , 1999, Cancer research.

[64]  J C Reed,et al.  IAP family proteins--suppressors of apoptosis. , 1999, Genes & development.

[65]  C. Rauch,et al.  Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo , 1999, Nature Medicine.

[66]  Emad S. Alnemri,et al.  Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner , 1999, The Journal of cell biology.

[67]  S. Korsmeyer,et al.  Cell Death in Development , 1999, Cell.

[68]  J C Reed,et al.  IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. , 1998, Cancer research.

[69]  T. Griffith,et al.  Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. , 1998, Journal of immunology.

[70]  S. Cory,et al.  The Bcl-2 protein family: arbiters of cell survival. , 1998, Science.

[71]  D. Vaux,et al.  Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts. , 1998, Trends in biochemical sciences.

[72]  J C Reed,et al.  Bax directly induces release of cytochrome c from isolated mitochondria. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[73]  J C Reed,et al.  IAPs block apoptotic events induced by caspase‐8 and cytochrome c by direct inhibition of distinct caspases , 1998, The EMBO journal.

[74]  G. Fantuzzi,et al.  Interleukin-18 Regulation of Interferon γ Production and Cell Proliferation as Shown in Interleukin-1β–Converting Enzyme (Caspase-1)-Deficient Mice , 1998 .

[75]  K. Maehara,et al.  Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor. , 1998, Circulation.

[76]  John Calvin Reed Double identity for proteins of the Bcl-2 family , 1997, Nature.

[77]  Dean P. Jones,et al.  Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked , 1997, Science.

[78]  D. Green,et al.  The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis , 1997, Science.

[79]  J C Reed,et al.  Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype , 1997, Science.

[80]  D. Livingston,et al.  Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE). , 1997, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[81]  Ping Li,et al.  Characterization of mice deficient in interleukin‐1β converting enzyme , 1997 .

[82]  G. Gil-Gómez,et al.  Bax alpha perturbs T cell development and affects cell cycle entry of T cells. , 1996, The EMBO journal.

[83]  A. Strasser,et al.  The cell death inhibitor Bcl‐2 and its homologues influence control of cell cycle entry. , 1996, The EMBO journal.

[84]  I. Chaudry,et al.  Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators. , 1996, Blood.

[85]  H. Petrie,et al.  Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death , 1996, The Journal of experimental medicine.

[86]  C A Smith,et al.  Identification and characterization of a new member of the TNF family that induces apoptosis. , 1995, Immunity.

[87]  M. Peter,et al.  Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor. , 1995, The EMBO journal.

[88]  M. Su,et al.  Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. , 1995, Science.

[89]  R. Kamen,et al.  Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock , 1995, Cell.

[90]  Y. S. Lin,et al.  Sepsis-induced apoptosis of the thymocytes in mice. , 1994, Journal of immunology.

[91]  Shai Shaham,et al.  The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme , 1993, Cell.

[92]  John Calvin Reed,et al.  Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. , 1993, Blood.

[93]  M. Raff,et al.  Social controls on cell survival and cell death , 1992, Nature.

[94]  S. Korsmeyer,et al.  bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation , 1989, Cell.

[95]  H. Hug,et al.  Caspases--their role in apoptosis and other physiological processes as revealed by knock-out studies. , 2002, Archivum immunologiae et therapiae experimentalis.

[96]  I. H. Engels,et al.  Caspases: more than just killers? , 2001, Trends in immunology.

[97]  G. Fantuzzi,et al.  Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice. , 1998, Blood.