Guidelines for the care and use of mammals in neuroscience and behavioral research

[1]  G. Collier,et al.  The ecological determinants of reinforcement in the rat. , 1972, Physiology & behavior.

[2]  N. Rowland,et al.  Regulatory drinking in rats with permanent access to a bitter fluid source , 1975, Physiology & Behavior.

[3]  J. Barg,et al.  Transient down-regulation of neonatal rat brain mu-opioid receptors upon in utero exposure to buprenorphine. , 1994, Brain research. Developmental brain research.

[4]  D. Blanchard,et al.  Conspecific aggression in the laboratory rat. , 1975, Journal of comparative and physiological psychology.

[5]  H. Stock,et al.  Gender and gonadal hormone effects in the olfactory bulbectomy animal model of depression , 2000, Pharmacology Biochemistry and Behavior.

[6]  J. Mench,et al.  Moods, minds and molecules: the neurochemistry of social behavior☆ , 1995 .

[7]  D. Mason,et al.  Monitoring of Anesthesia , 1997 .

[8]  R. McCarthy.  Pharmacology and Physiology in Anesthetic Practice. 3rd ed. , 1999 .

[9]  Marion Murray,et al.  Transplantation of genetically modified cells contributes to repair and recovery from spinal injury , 2002, Brain Research Reviews.

[10]  L R Squire,et al.  Relationship between magnitude of damage to the hippocampus and impaired recognition memory in monkeys , 2001, Hippocampus.

[11]  S. Snyder,et al.  Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase , 1995, Nature.

[12]  Beamer T Cunliffe.  Applying principles of aseptic surgery to rodents. , 1993 .

[13]  C. P. Richter.  Inborn nature of the rat's 24-hour clock. , 1971, Journal of comparative and physiological psychology.

[14]  E. Stricker.  Biological bases of hunger and satiety: therapeutic implications. , 1984, Nutrition reviews.

[15]  R. Dubner,et al.  A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia , 1987, Pain.

[16]  W. Löscher,et al.  A novel black-hooded mutant rat (ci3) with spontaneous circling behavior but normal auditory and vestibular functions , 2001, Neuroscience.

[17]  F. Oerlemans,et al.  Mice deficient in ubiquitous mitochondrial creatine kinase are viable and fertile. , 1995, Biochimica et biophysica acta.

[18]  E. Welsh,et al.  Comparison of three methods used for assessment of pain in dogs. , 1998, Journal of the American Veterinary Medical Association.

[19]  J. Ernst,et al.  Methods to evaluate the wellbeing of laboratory primates: comparisons of macaques and tamarins. , 1989, Laboratory animal science.

[20]  P. Fudala,et al.  Conditioned aversion after delay place conditioning with amphetamine , 1990, Pharmacology Biochemistry and Behavior.

[21]  G. Loeb,et al.  R. Lemon , 1985, Neuroscience.

[22]  E. Risley,et al.  CARRAGEENIN-INDUCED INFLAMMATION IN THE HIND LIMB OF THE RAT , 1962 .

[23]  J. Takahashi,et al.  Forward and reverse genetic approaches to behavior in the mouse. , 1994, Science.

[24]  G. Moberg.  When does stress become distress , 1999 .

[25]  P. Lowenstein,et al.  Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain. , 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

[26]  S. Straus,et al.  Publication of guidelines for the prevention and treatment of B virus infections in exposed persons. , 1995, MMWR. Morbidity and mortality weekly report.

[27]  C. Junghanss,et al.  Infectious risks and outcomes after stem cell transplantation: are nonmyeloablative transplants changing the picture? , 2002, Current opinion in infectious diseases.

[28]  K. Tan-No,et al.  A comparison between microwave irradiation and decapitation: basal levels of dynorphin and enkephalin and the effect of chronic morphine treatment on dynorphin peptides , 1997, Neuropeptides.

[29]  S. Lukas,et al.  A technique for chronic intragastric drug administration in the rat. , 1979, Life sciences.

[30]  I. Lucki,et al.  Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test. , 2002, European journal of pharmacology.

[31]  F. Halberg,et al.  Circadian Timing of Single Daily “Meal” Affects Survival of Mice 1 , 1973, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[32]  P. Brain,et al.  The effects of 5-HT receptor ligands on ultrasonic calling in mouse pups , 1991, Neuroscience & Biobehavioral Reviews.

[33]  L. Toth,et al.  Systemic bacterial invasion induced by sleep deprivation. , 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

[34]  A. Krarup,et al.  Evaluation of surrogate markers of impending death in the galactosamine-sensitized murine model of bacterial endotoxemia. , 1999, Laboratory animal science.

[35]  R. Pedersen,et al.  Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. , 1995, Genes & development.

[36]  S. Manuck,et al.  Psychosocial Factors Impair Vascular Responses of Coronary Arteries , 1991, Circulation.

[37]  R. Dubner,et al.  Attenuation of Pain in a Randomized Trial by Suppression of Peripheral Nociceptive Activity in the Immediate Postoperative Period , 2002, Anesthesia and analgesia.

[38]  N. Logothetis,et al.  Magnetic Resonance Imaging of Neuronal Connections in the Macaque Monkey , 2001, Neuron.

[39]  J. Mench.  Why It Is Important to Understand Animal Behavior. , 1998, ILAR journal.

[40]  G. Arendash,et al.  Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APPSW transgenic mouse model for Alzheimer’s disease , 1999, Journal of Neuroscience Methods.

[41]  G. Barr.  Antinociceptive effects of locally administered morphine in infant rats , 1999, Pain.

[42]  R S Balaban,et al.  Challenges in small animal noninvasive imaging. , 2001, ILAR journal.

[43]  D. Zhong,et al.  Neurobehavioral study of prenatal exposure to hyperthermia combined with irradiation in mice. , 1996, Neurotoxicology and teratology.

[44]  P Naitoh,et al.  Health effects of sleep deprivation. , 1990, Occupational medicine.

[45]  E. Alleva,et al.  Animal behavioral methods in neurotoxicity assessment: SGOMSEC joint report. , 1996, Environmental health perspectives.

[46]  S. Rimm-Kaufman,et al.  Prenatal stress alters brain biogenic amine levels in primates , 1998, Development and Psychopathology.

[47]  P. Bushnell,et al.  Neurobehavioral assessments of rats perinatally exposed to a commercial mixture of polychlorinated biphenyls. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[48]  S. Boggs.  Targeted gene modification for gene therapy of stem cells. , 1990, International journal of cell cloning.

[49]  R. Brady,et al.  Adeno-associated viral vector-mediated gene transfer results in long-term enzymatic and functional correction in multiple organs of Fabry mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[50]  E. D. Wilson,et al.  The influence of age on superovulation in the immature rat and mouse. , 1961, Endocrinology.

[51]  A. Wolf,et al.  Pain and stress in the human fetus. , 2004, Best practice & research. Clinical anaesthesiology.

[52]  Periconceptional folic acid exposure and risk of occurrent neural tube defects. , 1993 .

[53]  K. Miczek.  Intraspecies aggression in rats: Effects of d-amphetamine and chlordiazepoxide , 2004, Psychopharmacologia.

[54]  S. Manuck,et al.  Social instability and coronary artery atherosclerosis in cynomolgus monkeys , 1983, Neuroscience & Biobehavioral Reviews.

[55]  George A. Vogler,et al.  Anesthesia Equipment: Types and Uses , 1997 .

[56]  G. Collier,et al.  Defense of water balance in rats: behavioral and physiological responses to depletion. , 1967, Journal of comparative and physiological psychology.

[57]  N. Grahame,et al.  Genetic differences in intravenous cocaine self-administration between C57BL/6J and DBA/2J mice , 1995, Psychopharmacology.

[58]  W. Dewey,et al.  A comparison of the antinociceptive effects of opioid agonists in neonatal and adult rats in phasic and tonic nociceptive tests , 1994, Pharmacology Biochemistry and Behavior.

[59]  E. Rolls,et al.  Physiological mechanisms for thirst in the nonhuman primate. , 1982, The American journal of physiology.

[60]  R. Meisch,et al.  Drug self-administration , 1993 .

[61]  Gary J. Bennett,et al.  A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man , 1988, Pain.

[62]  R. Niesink,et al.  Social behavior of juvenile rats after in utero exposure to morphine: dose–time–effect relationship , 1999, Neuropharmacology.

[63]  H. Merskey.  Pain terms: a list with definitions and notes on usage. Recommended by the IASP Subcommittee on Taxonomy. , 1979, Pain.

[64]  Kathryn Bayne,et al.  Development of the human-research animal bond and its impact on animal well-being. , 2002, ILAR journal.

[65]  S. Woods,et al.  Effect of meal pattern during food restriction on body weight loss and recovery after refeeding , 1993, Physiology & Behavior.

[66]  G. Loeb,et al.  Electromyography for Experimentalists , 1986 .

[67]  J. Jaffe,et al.  Current concepts of addiction. , 1992, Research publications - Association for Research in Nervous and Mental Disease.

[68]  J. Speakman,et al.  Daily energy expenditure of the grey mouse lemur (Microcebus murinus): a small primate that uses torpor , 2000, Journal of Comparative Physiology B.

[69]  D. Mccurnin,et al.  Principles of surgical asepsis , 1985 .

[70]  K. Carey,et al.  A social tethering system for nonhuman primates used in laboratory research. , 1990, Laboratory animal science.

[71]  M. Delong,et al.  Functional and pathophysiological models of the basal ganglia , 1996, Current Opinion in Neurobiology.

[72]  E. Furth,et al.  Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[73]  P A Flecknell,et al.  Effects of surgery and analgesic administration on spontaneous behaviour in singly housed rats. , 2000, Research in veterinary science.

[74]  C. Cotman,et al.  Exercise: a behavioral intervention to enhance brain health and plasticity , 2002, Trends in Neurosciences.

[75]  R. Holson.  Euthanasia by decapitation: evidence that this technique produces prompt, painless unconsciousness in laboratory rodents. , 1992, Neurotoxicology and teratology.

[76]  K. Bayne,et al.  The Effects of Food Treat Provisioning and Human Interaction on the Behavioral Wel1-being of Rhesus Monkeys (Macaca mulatta). , 1993, Contemporary topics in laboratory animal science.

[77]  J. Crawley.  Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines , 1981, Pharmacology Biochemistry and Behavior.

[78]  G. Koren,et al.  A novel method using hair for determining hormonal levels in wildlife , 2002, Animal Behaviour.

[79]  Ralph B Dell,et al.  Sample size determination. , 2002, ILAR journal.

[80]  S. Haskins,et al.  Postoperative Support and Intensive Care , 1997 .

[81]  D. Larach,et al.  The effect of neuromuscular blockade with vecuronium on hemodynamic responses to noxious stimuli in the rat. , 1989, Anesthesiology.

[82]  Francis Collins,et al.  Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia , 1996, Cell.

[83]  P. Rakoczy,et al.  Adenovirus and adeno-associated virus vectors. , 2002, DNA and cell biology.

[84]  J. Crabbe,et al.  Identifying genes for alcohol and drug sensitivity: recent progress and future directions , 1999, Trends in Neurosciences.

[85]  C. Cunningham,et al.  Ethanol-induced conditioned taste aversion in 15 inbred mouse strains. , 2002, Behavioral neuroscience.

[86]  C. Shatz,et al.  Rapid Regulation of Brain-Derived Neurotrophic Factor mRNA within Eye-Specific Circuits during Ocular Dominance Column Formation , 2000, The Journal of Neuroscience.

[87]  W. Mason.  Early Social Deprivation in the Nonhuman Primates: Implications for Human Behavior , 1968 .

[88]  K. Gärtner,et al.  Stress response of rats to handling and experimental procedures , 1980, Laboratory animals.

[89]  M. Paule.  Validation of a Behavioral Test Battery for Monkeys , 2000 .

[90]  S. Snyder,et al.  Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans , 1997, Nature Medicine.

[91]  L. Fechter.  Combined effects of noise and chemicals. , 1995, Occupational medicine.

[92]  S. Goldberg,et al.  Behavioral analysis of drug dependence , 1986 .

[93]  David B Morton,et al.  Aversion to gaseous euthanasia agents in rats and mice. , 2002, Comparative medicine.

[94]  L. Toth,et al.  Stereotactic Surgery and Long-Term Maintenance of Cranial Implants in Research Animals. , 1999, Contemporary topics in laboratory animal science.

[95]  G. Moberg,et al.  The Biology of Animal Stress: Basic Principles and Implications for Animal Welfare , 2000 .

[96]  P. Brûlet,et al.  Targeted replacement of the homeobox gene Hox-3.1 by the Escherichia coli lacZ in mouse chimeric embryos. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[97]  Irene Kwan,et al.  Does animal experimentation inform human healthcare? Observations from a systematic review of international animal experiments on fluid resuscitation , 2002, BMJ : British Medical Journal.

[98]  J. Magnusson,et al.  Reduction of autotomy following peripheral neurectomy by a single injection of bupivacaine into the cingulum bundle of rats , 1996, Brain Research.

[99]  A. Rechtschaffen,et al.  Period-amplitude analysis of rat electroencephalogram: effects of sleep deprivation and exercise. , 1987, Sleep.

[100]  Y. W. Huang,et al.  Disseminated growth of a human multiple myeloma cell line in mice with severe combined immunodeficiency disease. , 1993, Cancer research.

[101]  C. Nemeroff,et al.  Long-Term Behavioral Effects of Repetitive Pain in Neonatal Rat Pups , 1999, Physiology & Behavior.

[102]  J. Grandy,et al.  Anesthesia of pups and kittens. , 1991, Journal of the American Veterinary Medical Association.

[103]  E. Theodorsson,et al.  Microwave irradiation increases recovery of neuropeptides from brain tissues , 1990, Peptides.

[104]  R. Bolles.  Species-specific defense reactions and avoidance learning. , 1970 .

[105]  R. Rodgers.  Anxious genes, emerging themes. Commentary on Belzung "The genetic basis of the pharmacological effects of anxiolytics" and Olivier et al. "The 5-HT(1A) receptor knockout mouse and anxiety". , 2001, Behavioural pharmacology.

[106]  A. Bhutta,et al.  Interactions of inflammatory pain and morphine in infant rats: long-term behavioral effects , 2001, Physiology & Behavior.

[107]  G. D. French,et al.  Wallerian degeneration is required for both neuropathic pain and sympathetic sprouting into the DRG , 1997, PAIN.

[108]  Jin Mo Chung,et al.  An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat , 1992, PAIN.

[109]  D. Dubuisson,et al.  The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats , 1977, Pain.

[110]  G. Bode,et al.  Integration of safety pharmacology endpoints into toxicology studies , 2002, Fundamental & clinical pharmacology.

[111]  P. Brain.  What does individual housing mean to a mouse? , 1975, Life sciences.

[112]  J. Rushen,et al.  Some issues in the interpretation of behavioural responses to stress. , 2000 .

[113]  J. Ladewig.  Chronic intermittent stress: a model for the study of long-term stressors. , 2000 .

[114]  Ivo Podreka,et al.  Receptor and Transporter Imaging Studies in Schizophrenia, Depression, Bulimia and Tourette's Disorder—Implications for Psychopharmacology- , 2002, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[115]  S. Foord,et al.  Transgenic gene knock-outs: functional genomics and therapeutic target selection. , 2000, Pharmacogenomics.

[116]  A. Dickenson,et al.  Epidural opioid analgesia in infant rats II: responses to carrageenan and capsaicin , 1999, Pain.

[117]  E. Chesler,et al.  Transgenic studies of pain and analgesia: mutation or background genotype? , 2001, The Journal of pharmacology and experimental therapeutics.

[118]  P. Geiselman,et al.  Body Temperature and Wheel Running Predict Survival Times in Rats Exposed to Activity-Stress , 1997, Physiology & Behavior.

[119]  R P Hamernik,et al.  Energy-independent factors influencing noise-induced hearing loss in the chinchilla model. , 2001, The Journal of the Acoustical Society of America.

[120]  R. Morris.  Spatial Localization Does Not Require the Presence of Local Cues , 1981 .

[121]  H. L. Evans,et al.  Effects of toluene inhalation on behavior and expired carbon dioxide in macaque monkeys. , 1985, Toxicology and applied pharmacology.

[122]  C. Cunningham,et al.  The paradox of persisting self-punitive behavior , 1981, Neuroscience & Biobehavioral Reviews.

[123]  B Bioulac,et al.  Reversal of Rigidity and Improvement in Motor Performance by Subthalamic High‐frequency Stimulation in MPTP‐treated Monkeys , 1993, The European journal of neuroscience.

[124]  R. Roth,et al.  Severe long-term 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the vervet monkey (Cercopithecus aethiops sabaeus) , 1997, Neuroscience.

[125]  M. Fanselow,et al.  Tonic nociception in neonatal rats , 1990, Pharmacology Biochemistry and Behavior.

[126]  C. B. Lynch,et al.  Adaptation to daily meal-timing and its effect on circadian temperature rhythms in two inbred strains of mice , 1987, Behavior genetics.

[127]  C. Hulsebosch,et al.  Changes in exploratory behavior as a measure of chronic central pain following spinal cord injury. , 2001, Journal of neurotrauma.

[128]  Breazile Je.  Physiologic basis and consequences of distress in animals. , 1987 .

[129]  Robert M. Sapolsky,et al.  Why Zebras Don't Get Ulcers , 1994 .

[130]  H. Harlow,et al.  Differential effect of early enrichment and deprivation on learning in the rhesus monkey (Macaca mulatta). , 1973 .

[131]  K. Pearson,et al.  Adaptive Locomotor Plasticity in Chronic Spinal Cats after Ankle Extensors Neurectomy , 2001, The Journal of Neuroscience.

[132]  N. Rowland,et al.  Intravenous self-feeding: long-term regulation of energy balance in rats. , 1977, Science.

[133]  G. Arendash,et al.  Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months , 2002, Physiology & Behavior.

[134]  Fitzsimons Jt.  Angiotensin, thirst, and sodium appetite: retrospect and prospect. , 1978 .

[135]  G. Wenger.  Cumulative dose-response curves in behavioral pharmacology , 1980, Pharmacology Biochemistry and Behavior.

[136]  G. S. Kanter.  Excretion and drinking after salt loading in dogs. , 1953, The American journal of physiology.

[137]  K. Papadakis,et al.  Predictive value of monitoring parameters in fetal surgery. , 1998, Journal of pediatric surgery.

[138]  R. Kole,et al.  Short-term and long-term modulation of gene expression by antisense therapeutics. , 2002, Current opinion in biotechnology.

[139]  G. Griebel,et al.  Measuring normal and pathological anxiety-like behaviour in mice: a review , 2001, Behavioural Brain Research.

[140]  M. Forsling,et al.  Inter-colony variation in fluid balance and its relationship to vasopressin secretion in male Sprague-Dawley rats , 1993, Laboratory animals.

[141]  R. G. Allen,et al.  Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[142]  G. Sieck,et al.  Mechanisms Underlying Greater Sensitivity of Neonatal Cardiac Muscle to Volatile Anesthetics , 2002, Anesthesiology.

[143]  G. Mower,et al.  Role of visual experience in activating critical period in cat visual cortex. , 1985, Journal of Neurophysiology.

[144]  Stephen G Lomber,et al.  The advantages and limitations of permanent or reversible deactivation techniques in the assessment of neural function , 1999, Journal of Neuroscience Methods.

[145]  Y. Stern,et al.  Intellectual changes in patients with MPTP‐induced parkinsonism , 1985, Neurology.

[146]  J. Geiger,et al.  Recovery of high-integrity mRNA from brains of rats killed by high-energy focused microwave irradiation. , 1999, Brain research. Brain research protocols.

[147]  R. Bolles.  Theory of Motivation , 1967 .

[148]  G. Barr,et al.  Formalin-induced c-fos expression in the spinal cord of fetal rats , 1997, Pain.

[149]  A. Fuchs,et al.  A method for measuring horizontal and vertical eye movement chronically in the monkey. , 1966, Journal of applied physiology.

[150]  H. Hackbarth,et al.  Euthanasia of rats with carbon dioxide-animal welfare aspects , 2000, Laboratory animals.

[151]  W. Slikker,et al.  Acute effects of delta-9-tetrahydrocannabinol in rhesus monkeys as measured by performance in a battery of complex operant tests. , 1988, The Journal of pharmacology and experimental therapeutics.

[152]  S Beggs,et al.  Book Review: The Neurobiology of Pain: Developmental Aspects , 2001, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[153]  P. V. Fonnesbeck.  Nutrient requirements of dogs , 1986 .

[154]  L. Toth,et al.  Defining the moribund condition as an experimental endpoint for animal research. , 2000, ILAR journal.

[155]  W. Klemm,et al.  EEG evaluation of humaneness of asphyxia and decapitation euthanasia of the laboratory rat. , 1975, Laboratory animal science.

[156]  R. Norman,et al.  Restraint inhibits luteinizing hormone and testosterone secretion in intact male rhesus macaques: effects of concurrent naloxone administration. , 1992, Neuroendocrinology.

[157]  J. Tannenbaum.  Ethics and Pain Research in Animals , 1999 .

[158]  H. Harlow,et al.  The Affectional Systems , 1965 .

[159]  D. Morton,et al.  Occupational Health and Safety in the Care and Use of Research Animals , 2005 .

[160]  H. Heller,et al.  Effects of sleep deprivation in neonatal rats. , 1998, American journal of physiology. Regulatory, integrative and comparative physiology.

[161]  J. Wrathall,et al.  Spinal cord contusion in the rat: Production of graded, reproducible, injury groups , 1985, Experimental Neurology.

[162]  B. T. Bennett,et al.  Essentials for animal research. A primer for research personnel. , 1990 .

[163]  M. Dennis.  Humane endpoints for genetically engineered animal models. , 2000, ILAR journal.

[164]  M. Colado,et al.  A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long term defect in thermoregulation , 2001, Psychopharmacology.

[165]  D. Olton,et al.  Animal Behavior Processes , 2022 .

[166]  L. Squire.  Memory Functions as Affected by Electroconvulsive Therapy a , 1986, Annals of the New York Academy of Sciences.

[167]  E. Blass,et al.  The development of morphine-induced antinociception in neonatal rats: A comparison of forepaw, hindpaw, and tail retraction from a thermal stimulus , 1993, Pharmacology Biochemistry and Behavior.

[168]  S. Manuck,et al.  Effects of Exercise on Cardiovascular Outcomes in Monkeys With Risk Factors for Coronary Heart Disease , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[169]  V. Moser.  The functional observational battery in adult and developing rats. , 2000, Neurotoxicology.

[170]  B Bioulac,et al.  Alleviation of experimental hemiparkinsonism by high‐frequency stimulation of the subthalamic nucleus in primates: A comparison with L‐dopa treatment , 1996, Movement disorders : official journal of the Movement Disorder Society.

[171]  M. Stock,et al.  Thermoregulatory effects of beta adrenoceptors: effects of selective agonists and the interaction of antagonists with isoproterenol and BRL-35135 in the cold. , 1993, Journal of Pharmacology and Experimental Therapeutics.

[172]  W. Russell,et al.  Ethical and Scientific Considerations Regarding Animal Testing and Research , 2011, PloS one.

[173]  L. Bellinger,et al.  Effect of deprivation and time of refeeding on food intake , 1975, Physiology & Behavior.

[174]  C. Robertson,et al.  Effects of anesthesia on polyamine metabolism and water content in the rat brain. , 1997, Journal of neurotrauma.

[175]  B. Platt,et al.  Long-term study of chronic oral aluminum exposure and spatial working memory in rats. , 2002, Behavioral neuroscience.

[176]  J. Moreau,et al.  Disruption of Prepulse Inhibition of Startle Reflex in a Neurodevelopmental Model of Schizophrenia: Reversal by Clozapine, Olanzapine and Risperidone But Not by Haloperidol , 2002, Neuropsychopharmacology.

[177]  A. Morrison.  Methods and welfare considerations in behavioral research with animals : report of a National Insititutes of Health Workshop / , 2002 .

[178]  P. Bushnell,et al.  Behavioral and neurochemical changes in rats dosed repeatedly with diisopropylfluorophosphate. , 1991, The Journal of pharmacology and experimental therapeutics.

[179]  J. Weeks,et al.  Microwave Fixation for the Determination of Cerebral Blood Volume in Rats , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[180]  R Hen,et al.  Enhanced aggressive behavior in mice lacking 5-HT1B receptor. , 1994, Science.

[181]  R. Cristiano.  Protein/DNA polyplexes for gene therapy. , 2002, Surgical oncology clinics of North America.

[182]  V. Laties.  Control of animal pain and distress in behavioral studies that use food deprivation or aversive stimulation. , 1987, Journal of the American Veterinary Medical Association.

[183]  Michelle Y. Cheng,et al.  Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus , 2002, Nature.

[184]  B. Rolls,et al.  Variety in the diet enhances intake in a meal and contributes to the development of obesity in the rat , 1983, Physiology & Behavior.

[185]  J. Schneider,et al.  Chronic exposure to low doses of MPTP. I. Cognitive deficits in motor asymptomatic monkeys , 1990, Brain Research.

[186]  G. Barr,et al.  Analgesic effects of intraventricular and intrathecal injection of morphine and ketocyclazocine in the infant rat , 1992, Brain Research.

[187]  A. Holmes.  Targeted gene mutation approaches to the study of anxiety-like behavior in mice , 2001, Neuroscience & Biobehavioral Reviews.

[188]  V. Moser.  Observational Batteries in Neurotoxicity Testing , 2000 .

[189]  C. Svendsen,et al.  Recent advances in stem cell neurobiology. , 2003, Advances and technical standards in neurosurgery.

[190]  K. Miczek,et al.  Aggression Escalated by Social Instigation or by Discontinuation of Reinforcement (“Frustration”) in Mice: Inhibition by Anpirtoline: A 5-HT1B Receptor Agonist , 2002, Neuropsychopharmacology.

[191]  P. Sánchez,et al.  Gli and hedgehog in cancer: tumours, embryos and stem cells , 2002, Nature Reviews Cancer.

[192]  D. Ingram,et al.  Age-related psychomotor and spatial learning deficits in 129/SvJ mice , 1999, Neurobiology of Aging.

[193]  D. Shepherdson,et al.  Alleviating stress in zoo animals with environmental enrichment. , 2000 .

[194]  E. Saravolac,et al.  Development of a murine hypothermia model for study of respiratory tract influenza virus infection. , 1997, Laboratory animal science.

[195]  D. Warburton.  Commentary on: “Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse.” Psychopharmacologia (1968) 13:222257 , 2002, Psychopharmacology.

[196]  T. A. Hewett,et al.  A comparison of euthanasia methods in rats, using carbon dioxide in prefilled and fixed flow rate filled chambers. , 1993, Laboratory animal science.

[197]  M. Zigmond,et al.  Animal models of parkinsonism using selective neurotoxins: clinical and basic implications. , 1989, International review of neurobiology.

[198]  G. Chrousos,et al.  Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[199]  C. Gomez-Sanchez,et al.  The effect of chronic food and water restriction on open-field behaviour and serum corticosterone levels in rats , 2000, Laboratory animals.

[200]  Larry J. Young,et al.  The neurobiology of social recognition, approach, and avoidance , 2002, Biological Psychiatry.

[201]  F. S. Saal,et al.  The use of live pups in a humane, injury-free test for infanticidal behaviour in male mice , 1989, Animal Behaviour.

[202]  P. Flecknell,et al.  Experimental and surgical technique in the rat. , 1980 .

[203]  A. Sclafani,et al.  Area postrema lesions impair flavor-toxin aversion learning but not flavor-nutrient preference learning. , 2002, Behavioral neuroscience.

[204]  H. Klein,et al.  Miniaturization: an overview of biotechnologies for monitoring the physiology and pathophysiology of rodent animal models. , 2002, ILAR journal.

[205]  M. Fanselow,et al.  Ethylketocyclazocine and bremazocine analgesia in neonatal rats , 1988, Pharmacology Biochemistry and Behavior.

[206]  N. Volkow,et al.  Overexpression of dopamine D2 receptors reduces alcohol self‐administration , 2001, Journal of neurochemistry.

[207]  R. E. Brown,et al.  Developing standardized behavioral tests for knockout and mutant mice. , 2000, ILAR journal.

[208]  J. Greer,et al.  Opioid depression of respiration in neonatal rats. , 1995, The Journal of physiology.

[209]  M. Deutsch,et al.  Time of death of CNS tumor-bearing rats can be reliably predicted by body weight-loss patterns. , 1991, Laboratory animal science.

[210]  M. Bush,et al.  Physiologic measures of nonhuman primates during physical restraint and chemical immobilization. , 1977, Journal of the American Veterinary Medical Association.

[211]  M. Onaya,et al.  Neurotoxicology , 2004, Hankey's Clinical Neurology.

[212]  E. D. Wilson,et al.  Comparison of superovulation in the immature mouse and rat. , 1962, Journal of reproduction and fertility.

[213]  B. Blumenkopf,et al.  Studies in autotomy: its pathophysiology and usefulness as a model of chronic pain , 1991, Pain.

[214]  A. Luks,et al.  Opioid-induced analgesia in neonatal dogs: pharmacodynamic differences between morphine and fentanyl. , 1998, The Journal of pharmacology and experimental therapeutics.

[215]  M. Kritchevsky.  Transient global amnesia: evidence for extensive, temporally graded retrograde amnesia , 1996 .

[216]  G. Kerr.  Nutritional requirements of subhuman primates. , 1972, Physiological reviews.

[217]  F. Weiss,et al.  Reversal of ethanol-seeking behavior by D1 and D2 antagonists in an animal model of relapse: differences in antagonist potency in previously ethanol-dependent versus nondependent rats. , 2002, The Journal of pharmacology and experimental therapeutics.

[218]  N. Goeders,et al.  Intracranial self-administration methodologies , 1987, Neuroscience & Biobehavioral Reviews.

[219]  G. Griebel,et al.  4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine hydrochloride (SSR125543A), a potent and selective corticotrophin-releasing factor(1) receptor antagonist. II. Characterization in rodent models of stress-related , 2002, The Journal of pharmacology and experimental therapeutics.

[220]  K. Herrup,et al.  Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. , 1995, Science.

[221]  D. Steindler,et al.  Transplantation of an indigenous neural stem cell population leading to hyperplasia and atypical integration. , 2002, Cloning and stem cells.

[222]  D. Morton,et al.  The HID50 (hypothermia-inducing dose 50): an alternative to the LD50 for measurement of bacterial virulence. , 1992, International journal of experimental pathology.

[223]  Martin Kavaliers,et al.  Antipredator responses and defensive behavior: ecological and ethological approaches for the neurosciences , 2001, Neuroscience & Biobehavioral Reviews.

[224]  R. Griffiths,et al.  A tethering system for intravenous and intragastric drug administration in the baboon , 1982, Pharmacology Biochemistry and Behavior.

[225]  R. Derr.  Pain perception in decapitated rat brain. , 1991, Life sciences.

[226]  James R Stellar,et al.  Effects of individual and concurrent stimulation of striatal D1 and D2 dopamine receptors on electrophysiological and behavioral output from rat basal ganglia. , 2002, The Journal of pharmacology and experimental therapeutics.

[227]  P. Dudchenko,et al.  Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I , 2005, Psychopharmacology.

[228]  A. Lalwani,et al.  The use of Preyer's reflex in evaluation of hearing in mice. , 2001, Acta oto-laryngologica.

[229]  R. Porsolt,et al.  Inter-group aggression in mice , 1975, Psychopharmacologia.

[230]  H. Wolff.  Headache and Other Head Pain , 1972 .

[231]  M. Davies,et al.  Nitrous oxide lacks the antinociceptive effect on the tail flick test in newborn rats. , 2000, Anesthesia and analgesia.

[232]  J. Crawley.  Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests 1 Published on the World Wide Web on 2 December 1998. 1 , 1999, Brain Research.

[233]  C. Cook,et al.  Hands-on and hands-off measurement of stress. , 2000 .

[234]  L. Soma.  Assessment of animal pain in experimental animals. , 1987, Laboratory animal science.

[235]  J. Pilcher,et al.  Sleep deprivation in the rat: IX. Recovery. , 1989, Sleep.

[236]  C. Wade,et al.  Urinary excretion of cortisol from rhesus monkeys (Macaca mulatta) habituated to restraint. , 1997, Contemporary topics in laboratory animal science.

[237]  Scott Deitchman,et al.  Recommendations for prevention of and therapy for exposure to B virus (cercopithecine herpesvirus 1). , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[238]  W. Merigan,et al.  Acrylamide-induced visual impairment in primates. , 1982, Toxicology and applied pharmacology.

[239]  William S. Stokes,et al.  Reducing Unrelieved Pain and Distress in Laboratory Animals Using Humane Endpoints , 2000 .

[240]  David G. Amaral,et al.  The primate amygdala and the neurobiology of social behavior: implications for understanding social anxiety , 2002, Biological Psychiatry.

[241]  M. Hofer,et al.  Ultrasonic vocalization by rat pups during recovery from deep hypothermia. , 1992, Developmental psychobiology.

[242]  C. Cunningham,et al.  Flavor preference conditioning by oral self-administration of ethanol , 1997, Psychopharmacology.

[243]  R. Lister.  The use of a plus-maze to measure anxiety in the mouse , 2004, Psychopharmacology.

[244]  J. Felmlee,et al.  American College of Radiology White Paper on MR Safety: 2004 update and revisions. , 2004, AJR. American journal of roentgenology.

[245]  M. Laudenslager,et al.  The Effect of Duration of Individual Housing on Social Behavior of Adult Male Bonnet Macaques (Macaca radiata). , 1998, Contemporary topics in laboratory animal science.

[246]  P. H. Griffiths,et al.  Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment , 1985, Veterinary Record.

[247]  Q. Lu,et al.  Non-viral gene delivery in skeletal muscle: a protein factory , 2003, Gene Therapy.

[248]  R. Debs,et al.  Cationic liposome-mediated gene delivery in vivo. , 2003, Methods in enzymology.

[249]  I. Whishaw,et al.  Impaired Spatial Performance in Rats with Retrosplenial Lesions: Importance of the Spatial Problem and the Rat Strain in Identifying Lesion Effects in a Swimming Pool , 2002, The Journal of Neuroscience.

[250]  P. Rolfe,et al.  In vivo near-infrared spectroscopy. , 2000, Annual review of biomedical engineering.

[251]  W. Paré,et al.  The emergence test: effects of psychotropic drugs on neophobic disposition in Wistar Kyoto (WKY) and Sprague Dawley Rats , 2001, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[252]  M. Papp,et al.  Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats , 2001, European Neuropsychopharmacology.

[253]  Dependence and withdrawal: problems with alprazolam , 1989 .

[254]  Lee A. Kirkpatrick,et al.  A Simple Guide to SPSS for Windows: For Versions 8.0 and 9.0. , 2000 .

[255]  M. Nosten-Bertrand,et al.  NOS and aggression , 1996, Trends in Neurosciences.

[256]  Leena Anil,et al.  Challenges of pain assessment in domestic animals. , 2002, Journal of the American Veterinary Medical Association.

[257]  P. Raboisson,et al.  The orofacial formalin test , 2004, Neuroscience & Biobehavioral Reviews.

[258]  S. Harrap,et al.  Behavioural and cardiovascular responses of rats to euthanasia using carbon dioxide gas , 1997, Laboratory animals.

[259]  J. Wallace,et al.  The assessment and control of the severity of scientific procedures on laboratory animals , 1990, Laboratory animals.

[260]  F. Crews,et al.  Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats , 2002, Pharmacology Biochemistry and Behavior.

[261]  R. Dubner,et al.  NMDA receptor antagonists attenuate mechanical hyperalgesia in rats with unilateral inflammation of the hindpaw , 1993, Neuroscience Letters.

[262]  J Glowacki,et al.  Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. , 1994, Genes & development.

[263]  J. W. Peck.  Rats defend different body weights depending on palatability and accessibility of their food. , 1978, Journal of comparative and physiological psychology.

[264]  A. Luciano,et al.  Surgical techniques. , 1971, Lancet.

[265]  S. Wixson.  The Role Of The IACUC In Assessing And Managing Pain And Distress In Research Animals , 1999 .

[266]  C. Mahaffey,et al.  Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent , 2002, Behavioural Brain Research.

[267]  Shruti Murthy,et al.  The IACUC Handbook , 2000 .

[268]  J. Ludders,et al.  Perioperative risk factors for puppies delivered by cesarean section in the United States and Canada. , 2000, Journal of the American Animal Hospital Association.

[269]  J. Falk,et al.  Oral cocaine pharmacokinetics and pharmacodynamics in a cumulative-dose regimen: pharmacokinetic-pharmacodynamic modeling of concurrent operant and spontaneous behavior within an operant context. , 2000, The Journal of pharmacology and experimental therapeutics.

[270]  T. Schachtman,et al.  Behavioral and physiologic effects of inapparent wound infection in rats. , 1992, Laboratory animal science.

[271]  C. Cunningham,et al.  Species difference in sensitivity to ethanol's hedonic effects. , 1993, Alcohol.

[272]  Y. W. Huang,et al.  Anti-CD54 (ICAM-1) has antitumor activity in SCID mice with human myeloma cells. , 1995, Cancer research.

[273]  R. Sánchez-Pernaute,et al.  Functional effect of adeno-associated virus mediated gene transfer of aromatic L-amino acid decarboxylase into the striatum of 6-OHDA-lesioned rats. , 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

[274]  E. Borell.  Neuroendocrine integration of stress and significance of stress for the performance of farm animals , 1995 .

[275]  C. O. Anderson,et al.  Early experience and complexity of social organization in groups of young rhesus monkeys (Macaca mulatta). , 1974 .

[276]  Paul D Acton,et al.  In vivo quantitative noninvasive imaging of gene transfer by single-photon emission computerized tomography. , 2003, Human gene therapy.

[277]  R. Norman,et al.  Restraint inhibits luteinizing hormone secretion in the follicular phase of the menstrual cycle in rhesus macaques. , 1994, Biology of reproduction.

[278]  C. Vorhees,et al.  Effects of prenatal cocaine on Morris and Barnes maze tests of spatial learning and memory in the offspring of C57BL/6J mice. , 2000, Neurotoxicology and teratology.

[279]  A. Rechtschaffen,et al.  Effects of method, duration, and sleep stage on rebounds from sleep deprivation in the rat. , 1999, Sleep.

[280]  G. Mcclearn,et al.  Structures and limits of animal models: examples from alcohol research. , 2000, ILAR journal.

[281]  D. Morton,et al.  A systematic approach for establishing humane endpoints. , 2000, ILAR journal.

[282]  S. Tufik,et al.  Paradoxical sleep deprivation facilitates subsequent corticosterone response to a mild stressor in rats , 2002, Neuroscience Letters.

[283]  C. E. Short,et al.  Recognition and Alleviation of Pain and Distress in Laboratory Animals.The Committee on Pain and Distress in Laboratory Animals, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council , 1993 .

[284]  Frans van Haaren,et al.  Methods in behavioral pharmacology , 1993 .

[285]  T. Cunliffe-Beamer.  Biomethodology and Surgical Techniques , 1983 .

[286]  E. Way.  Opioid Tolerance and Physical Dependence and Their Relationship , 1993 .

[287]  Fulvio Mavilio,et al.  Gene therapy , 1993, Nature.

[288]  R. N. Lemon,et al.  Multiple single unit recording in the cortex of monkeys using independently moveable microelectrodes , 1999, Journal of Neuroscience Methods.

[289]  J. Sharp,et al.  Stress-like responses to common procedures in rats: effect of the estrous cycle. , 2002, Contemporary topics in laboratory animal science.

[290]  B L McNaughton,et al.  LTP saturation and spatial learning disruption: effects of task variables and saturation levels , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[291]  O. Isacson,et al.  Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells , 2003, Annals of neurology.

[292]  J. Sabik,et al.  Halothane as an anesthetic for fetal surgery. , 1994, Journal of pediatric surgery.

[293]  C. Vorhees,et al.  Hippocampal expression of c‐fos is not essential for spatial learning , 2002, Synapse.

[294]  H. Brooks,et al.  Medical physiology , 1961 .

[295]  V. O'farrell.  Manual Of Canine Behaviour , 1991 .

[296]  T. Flotte,et al.  Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors , 2001, Gene Therapy.

[297]  C. Xerri,et al.  Vestibular compensation: role of visual motion cues in the recovery of posturo-kinetic functions in the cat , 1996, Behavioural Brain Research.

[298]  P. Willner.  Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation , 1997, Psychopharmacology.

[299]  M. Dolnikoff,et al.  Metabolic consequences of food restriction in rats , 1981, Physiology & Behavior.

[300]  P. Danneman,et al.  Evaluation of five agents/methods for anesthesia of neonatal rats. , 1997, Laboratory animal science.

[301]  P. F. Seitz.  Infantile Experience and Adult Behavior in Animal Subjects: II. Age of Separation from the Mother and Adult Behavior in the Cat , 1959 .

[302]  Markus Meister,et al.  Loss of Sex Discrimination and Male-Male Aggression in Mice Deficient for TRP2 , 2002, Science.

[303]  L. M. Terry,et al.  Use of hypothermia for general anesthesia in preweanling rodents , 1986, Physiology & Behavior.

[304]  Penny Hawkins,et al.  Recognizing and assessing pain, suffering and distress in laboratory animals: a survey of current practice in the UK with recommendations , 2002, Laboratory animals.

[305]  L. Sokoloff,et al.  Measurement of Free Glucose Turnover in Brain , 1980, Journal of neurochemistry.

[306]  Guidelines for the treatment of animals in behavioural research and teaching , 1995, Animal Behaviour.

[307]  Iver H. Iversen,et al.  Experimental analysis of behavior , 1991 .

[308]  J. Sedgwick,et al.  Gene knock-out technology: a methodological overview for the interested novice. , 1995, Journal of immunological methods.

[309]  K. Miczek,et al.  Repeated alcohol: behavioral sensitization and alcohol-heightened aggression in mice , 2002, Psychopharmacology.

[310]  K. Miczek,et al.  Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists , 1998, Psychopharmacology.

[311]  Michael E Greenberg,et al.  A Defect in Nurturing in Mice Lacking the Immediate Early Gene fosB , 1996, Cell.

[312]  H. L. Evans.  Nonhuman primates in behavioral toxicology: issues of validity, ethics and public health. , 1990, Neurotoxicology and teratology.

[313]  C. Svendsen,et al.  Stem cells for neurodegenerative disorders: where can we go from here? , 2002, BioDrugs.

[314]  W. Grove.  Statistical Methods for Rates and Proportions, 2nd ed , 1981 .

[315]  J. Geiger,et al.  Brain regional levels of adenosine and adenosine nucleotides in rats killed by high-energy focused microwave irradiation , 1996, Journal of Neuroscience Methods.

[316]  H. Kawamoto,et al.  Characterization of heat-hyperalgesia in an experimental trigeminal neuropathy in rats , 1997, Experimental Brain Research.

[317]  J. Horne.  Sleep function, with particular reference to sleep deprivation. , 1985, Annals of clinical research.

[318]  D. Laszlo,et al.  Studies on Pain. , 1950, Science.

[319]  M. Hoehn,et al.  Application of magnetic resonance to animal models of cerebral ischemia , 2001, Journal of magnetic resonance imaging : JMRI.

[320]  Guidelines for research involving recombinant DNA molecules. , 1978, Federal register.

[321]  J. Movshon,et al.  Anesthesia and Paralysis in Experimental Animals: Report of a Workshop held in Bethesda, Maryland, October 27, 1984 , 1988, Visual Neuroscience.

[322]  P. Nathanielsz,et al.  Level of postoperative analgesia is a critical factor in regulation of myometrial contractility after laparotomy in the pregnant baboon: implications for human fetal surgery. , 1999, American journal of obstetrics and gynecology.

[323]  M. Le Moal,et al.  Abolition and reversal of strain differences in behavioral responses to drugs of abuse after a brief experience. , 2000, Science.

[324]  M. Golub.  Labor analgesia and infant brain development , 1996, Pharmacology Biochemistry and Behavior.

[325]  L. Fogelson,et al.  Hypothermia and hypometabolism: sensitive indices of whole-body toxicity following exposure to metallic salts in the mouse. , 1990, Journal of toxicology and environmental health.

[326]  J. Crabbe,et al.  Genetics of mouse behavior: interactions with laboratory environment. , 1999, Science.

[327]  R. Gerlai.  Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? , 1996, Trends in Neurosciences.

[328]  E. Bézard,et al.  High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey , 1996, Neuroscience Letters.

[329]  H. Ursin,et al.  A method for studying responses and habituation to odors in rats. , 1982, Behavioral and neural biology.

[330]  J. Wallace.  Humane endpoints and cancer research. , 2000, ILAR journal.

[331]  J. W. Carpenter,et al.  Ferrets, rabbits, and rodents : clinical medicine and surgery , 2004 .

[332]  G. Gahrton,et al.  Suicide gene therapy: possible applications in haematopoietic disorders , 2001, Journal of internal medicine.

[333]  E. Stricker,et al.  Hormones and behavior: the biology of thirst and sodium appetite , 1988 .

[334]  J. Miller,et al.  Modulation of breathing by mu1 and mu2 opioid receptor stimulation in neonatal and adult rats. , 2001, Respiration physiology.

[335]  D. Rosenbaum,et al.  Cell Transplants Offer Promise for Stroke Recovery , 2003, The Journal of cardiovascular nursing.

[336]  P. Dudchenko,et al.  Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part II , 2005, Psychopharmacology.

[337]  N. Rowland,et al.  The physiology and brain mechanisms of feeding. , 1996, Nutrition.

[338]  G. Knott,et al.  Barriers in the Immature Brain , 2000, Cellular and Molecular Neurobiology.

[339]  C. Barnes.  Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. , 1979, Journal of comparative and physiological psychology.

[340]  R. Collins,et al.  Genetic dissection of susceptibility to audiogenic seizures in inbred mice. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[341]  Y. Ikarashi,et al.  Postmortem Changes in Catecholamines, Indoleamines, and Their Metabolites in Rat Brain Regions: Prevention with 10‐kW Microwave Irradiation , 1985, Journal of neurochemistry.

[342]  M. Novak,et al.  Chapter 13 – Behavioral Disorders , 1998 .

[343]  A. Rechtschaffen,et al.  Sleep deprivation in the rat: III. Total sleep deprivation. , 1989, Sleep.

[344]  W. Dement,et al.  Sleep: Changes in Threshold to Electroconvulsive Shock in Rats after Deprivation of "Paradoxical" Phase , 1965, Science.

[345]  E. Holman,et al.  Location preference and flavor aversion reinforced by amphetamine in rats , 1977 .

[346]  Felicity A. Huntingford,et al.  Some ethical issues raised by studies of predation and aggression , 1984, Animal Behaviour.

[347]  J. Glorioso,et al.  Gene delivery using herpes simplex virus vectors. , 2002, DNA and cell biology.

[348]  R. Porsolt,et al.  Behavioral despair in mice: a primary screening test for antidepressants. , 1977, Archives internationales de pharmacodynamie et de therapie.

[349]  P. Gaspar,et al.  Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. , 1995, Science.

[350]  E. Carstens,et al.  Recognizing pain and distress in laboratory animals. , 2000, ILAR journal.

[351]  M. Panjabi,et al.  Biomechanics of experimental spinal cord trauma. , 1978, Journal of neurosurgery.

[352]  J. L. Howard,et al.  Health effects of water restriction to motivate lever-pressing in rats. , 1994, Laboratory animal science.

[353]  D Semler,et al.  Effects of Two Weeks of Feed Restriction on Some Common Toxicologic Parameters in Sprague-Dawley Rats , 1993, Toxicologic pathology.

[354]  L. Solberg,et al.  Novel animal models of affective disorders. , 2001, Seminars in clinical neuropsychiatry.

[355]  V. Hamburger,et al.  Prenatal development of spontaneous and evoked activity in the rat (Rattus norvegicus albinus). , 1971, Behaviour.

[356]  Alison C. Smith,et al.  Surgery: Basic Principles and Procedures , 2002 .

[357]  Philippe Soriano.  Gene targeting in ES cells. , 1995, Annual review of neuroscience.

[358]  H. Bergman,et al.  Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. , 1990, Science.

[359]  R. McLay,et al.  Chronic Corticosterone Impairs Memory Performance in the Barnes Maze , 1998, Physiology & Behavior.

[360]  D Singer,et al.  Neonatal tolerance to hypoxia: a comparative-physiological approach. , 1999, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[361]  B. Thierry,et al.  The tail suspension test: A new method for screening antidepressants in mice , 2004, Psychopharmacology.

[362]  T. Jeneskog,et al.  Pain and distress in laboratory rodents and lagomorphs: Report of the Federation of European Laboratory Animal Science Associations (FELASA) Working Group on Pain and Distress accepted by the FELASA Board of Management November 1992 , 1994, Laboratory animals.

[363]  G. Collier.  The Economics of Hunger, Thirst, Satiety, and Regulation a , 1989, Annals of the New York Academy of Sciences.

[364]  R. Elwood,et al.  Ethical implications of studies on infanticide and maternal aggression in rodents , 1991, Animal Behaviour.

[365]  R. Nelson.  The Use of Genetic “Knockout” Mice in Behavioral Endocrinology Research , 1997, Hormones and Behavior.

[366]  L. Toth.  The moribund state as an experimental endpoint. , 1997, Contemporary topics in laboratory animal science.

[367]  S. Tonegawa,et al.  Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma. , 1997, Science.

[368]  P. Lachenbruch.  Statistical Power Analysis for the Behavioral Sciences (2nd ed.) , 1989 .

[369]  S. Manuck,et al.  Behaviorally Induced Heart Rate Reactivity and Atherosclerosis in Cynomolgus Monkeys , 1983, Psychosomatic medicine.

[370]  I. Bernstein.  The psychological well-being of nonhuman primates. , 1998 .

[371]  P. Sharp,et al.  Positive genetic selection for gene disruption in mammalian cells by homologous recombination. , 1989, Proceedings of the National Academy of Sciences of the United States of America.