Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis.
暂无分享,去创建一个
K. Lunetta | D. Geschwind | H. Hakonarson | J. Buxbaum | M. Cuccaro | J. Haines | M. Pericak-Vance | G. Schellenberg | M. Albert | J. Morris | C. DeCarli | L. Schneider | C. Lyketsos | D. Bennett | A. Myers | R. Petersen | J. Trojanowski | D. Blacker | J. Growdon | B. Hyman | B. Reisberg | T. Grabowski | A. Saykin | P. S. St George-Hyslop | J. Becker | R. Albin | A. Levey | J. Kaye | R. Mayeux | M. Sano | B. Boeve | H. Paulson | O. Lopez | L. Apostolova | D. Galasko | J. Brewer | M. Frosch | D. Dickson | J. Parisi | R. Doody | J. Quinn | N. Cairns | B. Ghetti | J. Ringman | E. Reiman | E. Martin | J. Vance | L. Honig | D. Royall | S. Arnold | L. Farrer | H. Chui | J. Kramer | W. Seeley | K. Welsh-Bohmer | E. Bigio | S. Weintraub | J. Manly | R. Tanzi | M. Gearing | A. Goate | J. Kauwe | C. Cruchaga | M. Carrasquillo | S. Younkin | T. Obisesan | S. Strittmatter | H. Vinters | Denis A. Evans | P. D. De Jager | W. Kukull | T. Wisniewski | T. Foroud | P. Crane | V. Henderson | J. Troncoso | C. Reitz | S. Small | A. Boxer | A. Karydas | D. Marson | K. Wilhelmsen | M. Huentelman | J. Lah | K. Hall | H. Hendrie | J. Reisch | A. McDavid | T. Bird | D. Fardo | A. Naj | G. Jun | G. Beecham | B. Vardarajan | B. Kunkle | C. Baldwin | M. Kamboh | E. Larson | E. Rogaeva | D. Tsuang | O. Valladares | K. Hamilton-Nelson | K. Faber | L. Cantwell | T. Beach | Chang-En Yu | M. Fallin | G. Jarvik | J. Vonsattel | R. Rosenberg | N. Graff-Radford | S. Asthana | C. Carlsson | M. Sager | S. O'Bryant | R. Swerdlow | N. Kowall | C. Hulette | R. Woltjer | E. Roberson | S. Ferris | F. LaFerla | E. Peskind | T. Golde | N. Ertekin-Taner | W. McCormick | Ge Li | S. Craft | S. McCurry | J. Olichney | J. Burke | E. Abner | H. Klein | T. Wingo | L. Barnes | S. Barral | Amanda Kuzma | R. Duara | M. Logue | C. Atwood | R. Vassar | R. Go | M. Raskind | J. Burns | D. Cribbs | A. Lieberman | V. V. Van Deerlin | J. Leverenz | L. V. Van Eldik | R. Barber | L. Qu | M. Katz | C. Cao | R. Carney | K. Fallon | F. Martiniuk | A. Pierce | W. Poon | H. Potter | A. Raj | J. Sonnen | S. Spina | J. Williamson | G. Byrd | R. Go | David A. Bennett | Y. Leung | Yi Zhao | J. Malamon | T. Fairchild | R. Huebinger | M. Mesulam | C. Keene | L. Adams | J. Mez | Michael A. Schmidt | Jaeyoon Chung | S. Mukherjee | S. McDonough | Takiyah D. Starks | T. Montine | R. Lipton | Lee‐way Jin | L. Harrell | Hank Paulson | B. Miller | M. Albert | M. Farlow | V. W. Henderson | Paul K. Crane | Eric B. Larson | J. Schneider | J. Chung | V. V. van Deerlin | Chuang‐Kuo Wu | Ronald Kim | J. Brewer | H. Rosen | R. Swerdlow | Li-Sao Wang | Izri Martinez | Temitope Ayodele | Melissa Jean-Francois | V. Henderson | Lei Yu | John Hardy | A. Mckee | Eliezer Masliah | Melissa Jean‐Francois | P. Adams | T. Starks | B. Miller | R. Stern | J. Bowen | J. Gilbert | R. Hamilton | A. Kuzma | J. Morris | C. Miller | R. Green | Malcom Dick | M. Jean‐Francois | J. Haines | J. Morris | J. Morris | J. Schneider | Jesse B. Mez | Murray M. Raskind | E. Masliah | Victor W Henderson | M. Fallin
[1] Sterling C. Johnson,et al. Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease. , 2020, JAMA neurology.
[2] Joanne C. Beer,et al. Population-based genome-wide association study of cognitive decline in older adults free of dementia: identification of a novel locus for the attention domain , 2019, Neurobiology of Aging.
[3] C. DeCarli,et al. Neuropathological Diagnoses of Demented Hispanic, Black, and Non-Hispanic White Decedents Seen at an Alzheimer's Disease Center. , 2019, Journal of Alzheimer's Disease.
[4] Brian A. Gordon,et al. Assessment of Racial Disparities in Biomarkers for Alzheimer Disease , 2019, JAMA neurology.
[5] Genetic,et al. Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing , 2019, Nature Genetics.
[6] Nick C Fox,et al. Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing , 2019, Nature Genetics.
[7] Kevin F. Bieniek,et al. Ethnoracial differences in Alzheimer’s disease from the FLorida Autopsied Multi-Ethnic (FLAME) cohort , 2019, Alzheimer's & Dementia.
[8] Ryan L. Collins,et al. The mutational constraint spectrum quantified from variation in 141,456 humans , 2020, Nature.
[9] Annie W Shieh,et al. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder , 2018, Science.
[10] M. Cuccaro,et al. Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations , 2018, PLoS genetics.
[11] Jenny I. Shen,et al. Kidney Disease Among African Americans: A Population Perspective. , 2018, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[12] A. Gross,et al. Dementia, Alzheimer's Disease, and Mortality after Hemodialysis Initiation. , 2018, Clinical journal of the American Society of Nephrology : CJASN.
[13] D. Hebert,et al. EDEM1's mannosidase-like domain binds ERAD client proteins in a redox-sensitive manner and possesses catalytic activity , 2018, Journal of Biological Chemistry.
[14] L. Farrer,et al. Genome‐wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test , 2018, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[15] H. Najafabadi,et al. Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease , 2017, Nature Communications.
[16] F. McMahon,et al. Sodium valproate rescues expression of TRANK1 in iPSC-derived neural cells that carry a genetic variant associated with serious mental illness , 2017, bioRxiv.
[17] Nick C Fox,et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease , 2017, Nature Genetics.
[18] D. Serie,et al. African American exome sequencing identifies potential risk variants at Alzheimer disease loci , 2017, Neurology: Genetics.
[19] J. Attems,et al. Common Impact of Chronic Kidney Disease and Brain Microhemorrhages on Cerebral Aβ Pathology in SHRSP , 2017, Brain pathology.
[20] Janice M. Fullerton,et al. Identification of shared risk loci and pathways for bipolar disorder and schizophrenia , 2017, PloS one.
[21] K. Lunetta,et al. Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans , 2017, Alzheimer's & Dementia.
[22] J. Billard,et al. Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[23] Sung-Hoon Kim,et al. VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Aβ accumulation via enhancement of ERK phosphatase VHR activity , 2016, Scientific Reports.
[24] Lilah M. Besser,et al. Neuropathologic differences by race from the National Alzheimer's Coordinating Center , 2016, Alzheimer's & Dementia.
[25] Derek J Van Booven,et al. ABCA7 frameshift deletion associated with Alzheimer disease in African Americans , 2016, Neurology: Genetics.
[26] Timothy J. Hohman,et al. Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk , 2016, Alzheimer's & Dementia.
[27] D. Geschwind,et al. Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes , 2016, Neuron.
[28] K. Nagata,et al. Role of the cytoplasmic isoform of RBFOX1/A2BP1 in establishing the architecture of the developing cerebral cortex , 2015, Molecular Autism.
[29] M. Holzenberger,et al. Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance , 2015, The Journal of Neuroscience.
[30] S. Leurgans,et al. Mixed pathology is more likely in black than white decedents with Alzheimer dementia , 2015, Neurology.
[31] S. Lincoln,et al. TREM2 is associated with increased risk for Alzheimer’s disease in African Americans , 2015, Molecular Neurodegeneration.
[32] Joris M. Mooij,et al. MAGMA: Generalized Gene-Set Analysis of GWAS Data , 2015, PLoS Comput. Biol..
[33] J. Gallacher,et al. Convergent genetic and expression data implicate immunity in Alzheimer's disease , 2014, Alzheimer's & Dementia.
[34] Hitoshi Suzuki,et al. Alternative splicing regulation of APP exon 7 by RBFox proteins , 2014, Neurochemistry International.
[35] K. Lunetta,et al. Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans , 2014, Alzheimer's & Dementia.
[36] S. Djurovic,et al. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia , 2013, Molecular Psychiatry.
[37] P. Crane,et al. Alzheimer’s Disease: Analyzing the Missing Heritability , 2013, PloS one.
[38] Nick C Fox,et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease , 2013, Nature Genetics.
[39] R. Mayeux,et al. TREM2 and neurodegenerative disease. , 2013, The New England journal of medicine.
[40] H. Prats,et al. Api5 Contributes to E2F1 Control of the G1/S Cell Cycle Phase Transition , 2013, PloS one.
[41] Oscar L Lopez,et al. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. , 2013, JAMA.
[42] Curtis Tatsuoka,et al. Modeling the heterogeneity in risk of progression to Alzheimer's disease across cognitive profiles in mild cognitive impairment , 2013, Alzheimer's Research & Therapy.
[43] S. Cichon,et al. Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder , 2013, Molecular Psychiatry.
[44] A. Singleton,et al. TREM2 variants in Alzheimer's disease. , 2013, The New England journal of medicine.
[45] A. Hofman,et al. Variant of TREM2 associated with the risk of Alzheimer's disease. , 2013, The New England journal of medicine.
[46] S Cichon,et al. Genome-wide association of mood-incongruent psychotic bipolar disorder , 2012, Translational Psychiatry.
[47] Lan Jiang,et al. Genome‐Wide Association and Linkage Study in the Amish Detects a Novel Candidate Late‐Onset Alzheimer Disease Gene , 2012, Annals of human genetics.
[48] J. Schneider,et al. Overview and findings from the religious orders study. , 2012, Current Alzheimer research.
[49] Stephen J. Smith,et al. Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors , 2012, Nature.
[50] J. Schneider,et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. , 2012, The Journal of clinical investigation.
[51] W. Kukull,et al. Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010 , 2012, Journal of neuropathology and experimental neurology.
[52] P. Sham,et al. Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases , 2011, Genetic epidemiology.
[53] Nick C Fox,et al. Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease , 2011, Nature Genetics.
[54] D. G. Clark,et al. Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease , 2011, Nature Genetics.
[55] Sudha Seshadri,et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. , 2010, JAMA.
[56] Y. Kitamura,et al. Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-β Generation , 2010, The Journal of Neuroscience.
[57] E. Masliah,et al. Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice , 2010, Cell.
[58] T. Kadowaki,et al. Neuronal IGF‐1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer's disease , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[59] P. Bosco,et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease , 2009, Nature Genetics.
[60] D. Hebert,et al. EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex. , 2009, Molecular cell.
[61] Kyong-Tai Kim,et al. Negative regulation of ERK activity by VRK3-mediated activation of VHR phosphatase , 2006, Nature Cell Biology.
[62] D. Small,et al. Heparin activates beta-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme. , 2006, Biochemistry.
[63] L. Fratiglioni,et al. Role of genes and environments for explaining Alzheimer disease. , 2006, Archives of general psychiatry.
[64] D. Black,et al. Molecular basis of RNA recognition by the human alternative splicing factor Fox‐1 , 2006, The EMBO journal.
[65] R. Huganir,et al. MAPK cascade signalling and synaptic plasticity , 2004, Nature Reviews Neuroscience.
[66] P. Wesseling,et al. Heparan sulphate proteoglycans in Alzheimer's disease and amyloid‐related disorders , 2003, The Lancet Neurology.
[67] Maurizio Molinari,et al. Role of EDEM in the Release of Misfolded Glycoproteins from the Calnexin Cycle , 2003, Science.
[68] Martin Holzenberger,et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice , 2003, Nature.
[69] P. Wesseling,et al. Accumulation of heparan sulfate proteoglycans in cerebellar senile plaques , 2002, Neurobiology of Aging.
[70] P. Wesseling,et al. Heparan sulfate proteoglycan expression in cerebrovascular amyloid β deposits in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis (Dutch) brains , 2001, Acta Neuropathologica.
[71] Karl Deisseroth,et al. Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology , 2001, Nature Neuroscience.
[72] R. Costa,et al. Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan , 2001, Neurology.
[73] T. Wight,et al. Perlecan Binds to the β‐Amyloid Proteins (Aβ) of Alzheimer's Disease, Accelerates Aβ Fibril Formation, and Maintains Aβ Fibril Stability , 1997 .
[74] H. Fillit,et al. Heparin promotes ß-secretase cleavage of the Alzheimer's amyloid precursor protein , 1997, Neurochemistry International.
[75] Alexander Meissner,et al. Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease. , 2015, JAMA neurology.
[76] Nick C Fox,et al. Letter abstract - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's Disease , 2009 .
[77] M. Albert,et al. Results of a high-resolution genome screen of 437 Alzheimer's disease families. , 2003, Human molecular genetics.