CpG island methylation profiling in human salivary gland adenoid cystic carcinoma

DNA methylation is a fundamental epigenetic event associated with physiologic and pathologic conditions, including cancer. Hypermethylation of CpG islands at active gene promoters leads to transcriptional repression, whereas hypomethylation is associated with gene overexpression. The aim of this study was to identify genes in adenoid cystic carcinoma (ACC) of salivary gland strongly deregulated by epigenetic CpG island methylation, to validate selected genes by conventional techniques, and to correlate the findings with clinicopathologic factors.

[1]  E. Rouchka,et al.  In Silico characterization of phosphorylase kinase: evidence for an alternate intronic polyadenylation site in PHKG1. , 2007, Molecular genetics and metabolism.

[2]  P. Lobie,et al.  Transcriptional activation of p53 by Pitx1 , 2007, Cell Death and Differentiation.

[3]  G. Glinsky,et al.  Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. , 2005, The Journal of clinical investigation.

[4]  Thomas B Bair,et al.  Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells , 2010, Genes, chromosomes & cancer.

[5]  P. Dolara,et al.  Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. , 2010, Chemico-biological interactions.

[6]  Thomas L. Dunwell,et al.  A Genome-wide screen identifies frequently methylated genes in haematological and epithelial cancers , 2010, Molecular Cancer.

[7]  Klaus Jung,et al.  Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis. , 2007, The Journal of urology.

[8]  Daiya Takai,et al.  Comprehensive analysis of CpG islands in human chromosomes 21 and 22 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Pearlly S Yan,et al.  High-throughput methylation profiling by MCA coupled to CpG island microarray. , 2007, Genome research.

[10]  W. Hou,et al.  Regulation of Mitochondrial Apoptotic Events by p53-mediated Disruption of Complexes between Antiapoptotic Bcl-2 Members and Bim* , 2010, The Journal of Biological Chemistry.

[11]  V. Moreno,et al.  Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease , 2009, British Journal of Cancer.

[12]  C. Tabin,et al.  Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity. , 1999, Science.

[13]  W. Kiess,et al.  Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[14]  J. Califano,et al.  Quantitative Methylation Profiles for Multiple Tumor Suppressor Gene Promoters in Salivary Gland Tumors , 2010, PloS one.

[15]  R. Mayor,et al.  The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction , 2009, Development.

[16]  A. Suzuki,et al.  The γ-Parvin-Integrin-Linked Kinase Complex Is Critically Involved in Leukocyte-Substrate Interaction1 , 2006, The Journal of Immunology.

[17]  M. You,et al.  Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor , 2010, Oncogene.

[18]  Z. Estrov,et al.  Genome-wide DNA methylation profiling of chronic lymphocytic leukemia allows identification of epigenetically repressed molecular pathways with clinical impact , 2010, Epigenetics.

[19]  J. Cerhan,et al.  Genetic Variation in the Chromosome 17q23 Amplicon and Breast Cancer Risk , 2009, Cancer Epidemiology Biomarkers & Prevention.

[20]  Andrew J. Wilson,et al.  Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. , 2010, Cancer research.

[21]  K. Kaestner,et al.  Foxl1 Controls the Wnt/β-Catenin Pathway by Modulating the Expression of Proteoglycans in the Gut* , 2001, The Journal of Biological Chemistry.

[22]  R. Liddington,et al.  Structural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs)* , 2010, The Journal of Biological Chemistry.

[23]  D. Teti,et al.  FOXE1 is a target for aberrant methylation in cutaneous squamous cell carcinoma , 2010, The British journal of dermatology.

[24]  Irving L. Weissman,et al.  A comprehensive methylome map of lineage commitment from hematopoietic progenitors , 2010, Nature.

[25]  H. Paulson,et al.  Diversity in Tissue Expression, Substrate Binding, and SCF Complex Formation for a Lectin Family of Ubiquitin Ligases* , 2008, Journal of Biological Chemistry.

[26]  T. Noda,et al.  Expression of Pou3f3/Brn‐1 and its genomic methylation in developing auditory epithelium , 2009, Developmental neurobiology.

[27]  E. Lam,et al.  The emerging roles of forkhead box (Fox) proteins in cancer , 2007, Nature Reviews Cancer.

[28]  M. Pelizzo,et al.  The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors , 2009, PLoS genetics.

[29]  A. Lasa,et al.  MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias , 2004, Leukemia.

[30]  T. Rauch,et al.  CpG island hypermethylation in human astrocytomas. , 2010, Cancer research.

[31]  Tim Hui-Ming Huang,et al.  Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. , 2002, Genes & development.

[32]  M. Westerfield,et al.  Lbx2 regulates formation of myofibrils , 2009, BMC Developmental Biology.

[33]  M. Lowe,et al.  The triglyceride lipases of the pancreas Published, JLR Papers in Press, October 1, 2002. DOI 10.1194/jlr.R200012-JLR200 , 2002, Journal of Lipid Research.

[34]  K. Cornetta,et al.  The orphan receptor COUP-TFII regulates G2/M progression of breast cancer cells by modulating the expression/activity of p21(WAF1/CIP1), cyclin D1, and cdk2. , 2000, Biochemical and Biophysical Research Communications - BBRC.

[35]  W. Lam,et al.  Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells , 2005, Nature Genetics.

[36]  L. Penland,et al.  Use of a cDNA microarray to analyse gene expression patterns in human cancer , 1996, Nature Genetics.

[37]  S. Baylin,et al.  Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. , 1999, Cancer research.

[38]  K. Washington,et al.  DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett’s adenocarcinoma , 2008, Gut.

[39]  J. Simon,et al.  MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF‐β and pro‐inflammatory cytokines , 2005, Experimental dermatology.