Atlas of Genetics and Cytogenetics in Oncology and Haematology in 2013

The Atlas of Genetics and Cytogenetics in Oncology and Haematology (http://AtlasGeneticsOncology.org) is a peer-reviewed internet journal/encyclopaedia/database focused on genes implicated in cancer, cytogenetics and clinical entities in cancer and cancer-prone hereditary diseases. The main goal of the Atlas is to provide review articles that describe complementary topics, namely, genes, genetic abnormalities, histopathology, clinical diagnoses and a large iconography. This description, which was historically based on karyotypic abnormalities and in situ hybridization (fluorescence in situ hybridization) techniques, now benefits from comparative genomic hybridization and massive sequencing, uncovering a tremendous amount of genetic rearrangements. As the Atlas combines different types of information (genes, genetic abnormalities, histopathology, clinical diagnoses and external links), its content is currently unique. The Atlas is a cognitive tool for fundamental and clinical research and has developed into an encyclopaedic work. In clinical practice, it contributes to the cytogenetic diagnosis and may guide treatment decision making, particularly regarding rare diseases (because they are numerous and are frequently encountered). Readers as well as the authors of the Atlas are researchers and/or clinicians.

[1]  K. Umesono,et al.  Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML , 1991, Cell.

[2]  D. Grimwade,et al.  The pathogenesis of acute promyelocytic leukaemia: evaluation of the role of molecular diagnosis and monitoring in the management of the disease , 1999, British journal of haematology.

[3]  F. Mitelman,et al.  Mitelman database of chromosome aberrations and gene fusions in cancer , 2014 .

[4]  J. Licht,et al.  Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. , 1999, Blood.

[5]  P G Pelicci,et al.  Genetics of APL and the molecular basis of retinoic acid treatment , 1997, International journal of cancer.

[6]  K. Howe,et al.  Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies. , 1998, American journal of human genetics.

[7]  T. Hubbard,et al.  A census of human cancer genes , 2004, Nature Reviews Cancer.

[8]  H. Pearson.  Biology's name game , 2001, Nature.

[9]  Philippe Dessen,et al.  Atlas of Genetics and Cytogenetics in Oncology and Haematology, an Interactive Database , 2000, Nucleic Acids Res..

[10]  Jean-Loup Huret,et al.  An internet database on genetics in oncology , 2003, Oncogene.

[11]  Christine Chomienne,et al.  The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus , 1990, Nature.

[12]  Zhen-yi Wang,et al.  Retinoic acid regulatory pathways, chromosomal translocations, and acute promyelocytic leukemia , 1996, Genes, chromosomes & cancer.

[13]  Pier Paolo Pandolfi,et al.  The transcriptional role of PML and the nuclear body , 2000, Nature Cell Biology.

[14]  Jian-Min Chen,et al.  Chromothripsis: a new molecular mechanism in cancer development , 2012 .

[15]  Gilad Bracha,et al.  Mirrors: design principles for meta-level facilities of object-oriented programming languages , 2004, OOPSLA.

[16]  Tatiana A. Tatusova,et al.  Entrez Gene: gene-centered information at NCBI , 2004, Nucleic Acids Res..

[17]  S. Hoyer-Fender,et al.  Centrosomes in fertilization, early embryonic development, stem cell division, and cancer , 2012 .

[18]  Mingming Jia,et al.  COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer , 2010, Nucleic Acids Res..

[19]  O. Griffith,et al.  Mitelman Database (Chromosome Aberrations and Gene Fusions in Cancer) , 2014 .

[20]  P G Pelicci,et al.  Characterization of the PML-RAR alpha chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocation. , 1992, Cancer research.

[21]  Maryam Mehrpour,et al.  Mechanisms and regulation of autophagy in mammalian cells , 2012 .

[22]  G. Hong,et al.  Nucleic Acids Research , 2015, Nucleic Acids Research.

[23]  Mary Goldman,et al.  The UCSC Genome Browser database: extensions and updates 2013 , 2012, Nucleic Acids Res..

[24]  Philippe Dessen,et al.  Atlas of Genetics and Cytogenetics in Oncology and Haematology, year 2003 , 2003, Nucleic Acids Res..

[25]  Mary Goldman,et al.  The UCSC Genome Browser database: extensions and updates 2011 , 2011, Nucleic Acids Res..