Characterisation of nerve‐mediated ATP release from bladder detrusor muscle and its pathological implications.

. Background and Purpose. To characterise the molecular mechanisms that determine variability of atropine-resistance of nerve-mediated contractions in human and guinea-pig detrusor smooth muscle Experimental Approach .

[1]  A. Kanai,et al.  Influence of sildenafil on the purinergic components of nerve‐mediated and urothelial ATP release from the bladder of normal and spinal cord injured mice , 2019, British journal of pharmacology.

[2]  Steve Alexander,et al.  Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers , 2018, British journal of pharmacology.

[3]  Alasdair J. G. Gray,et al.  The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY , 2017, Nucleic Acids Res..

[4]  Arthur Christopoulos,et al.  THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein‐coupled receptors , 2017, British journal of pharmacology.

[5]  Adam J Pawson,et al.  THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes , 2017, British journal of pharmacology.

[6]  Adam J Pawson,et al.  THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Ligand‐gated ion channels , 2017, British journal of pharmacology.

[7]  C. Fry,et al.  On the origin of spontaneous activity in the bladder , 2016, BJU International.

[8]  C. Fry,et al.  Contractile effects and receptor analysis of adenosine-receptors in human detrusor muscle from stable and neuropathic bladders , 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

[9]  K. McVary,et al.  A1 Adenosine Receptor–Mediated Inhibition of Parasympathetic Neuromuscular Transmission in Human and Murine Urinary Bladder , 2016, The Journal of Pharmacology and Experimental Therapeutics.

[10]  P. Correia‐de‐Sá,et al.  Impairment of ATP hydrolysis decreases adenosine A1 receptor tonus favoring cholinergic nerve hyperactivity in the obstructed human urinary bladder , 2015, Purinergic Signalling.

[11]  C. Kennedy.  ATP as a cotransmitter in the autonomic nervous system , 2015, Autonomic Neuroscience.

[12]  John C McGrath,et al.  Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP , 2015, British journal of pharmacology.

[13]  A. Taylor,et al.  Enhanced purinergic contractile responses and P2X1 receptor expression in detrusor muscle during cycles of hypoxia–glucopenia and reoxygenation , 2013, Experimental physiology.

[14]  J. Stull,et al.  Signalling to contractile proteins by muscarinic and purinergic pathways in neurally stimulated bladder smooth muscle , 2012, The Journal of physiology.

[15]  N. Sträter,et al.  Cellular function and molecular structure of ecto-nucleotidases , 2012, Purinergic Signalling.

[16]  John S. Young,et al.  Spontaneous purinergic neurotransmission in the mouse urinary bladder , 2008, Journal of Physiology.

[17]  J. Sévigny,et al.  Specificity of the ecto‐ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases , 2007, British journal of pharmacology.

[18]  D. F. Wilson,et al.  DOES NITRIC OXIDE MODULATE TRANSMITTER RELEASE AT THE MAMMALIAN NEUROMUSCULAR JUNCTION? , 2007, Clinical and experimental pharmacology & physiology.

[19]  C. Kennedy,et al.  Identification of Atropine- and P2X1 Receptor Antagonist-Resistant, Neurogenic Contractions of the Urinary Bladder , 2007, The Journal of Neuroscience.

[20]  J. Sévigny,et al.  The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance , 2006, Purinergic Signalling.

[21]  V. Mutafova-Yambolieva,et al.  beta-NAD is a novel nucleotide released on stimulation of nerve terminals in human urinary bladder detrusor muscle. , 2006, American journal of physiology. Renal physiology.

[22]  C. Grassi,et al.  Modulation of Cav1 and Cav2.2 channels induced by nitric oxide via cGMP-dependent protein kinase , 2004, Neurochemistry International.

[23]  C. Fry,et al.  The contractile potency of adenosine triphosphate and ecto-adenosine triphosphatase activity in guinea pig detrusor and detrusor from patients with a stable, unstable or obstructed bladder. , 2002, The Journal of urology.

[24]  G. Burnstock,et al.  Alterations in cholinergic and purinergic signaling in a model of the obstructed bladder. , 2001, The Journal of urology.

[25]  C. Fry,et al.  Na+/Ca2+ exchange and its role in intracellular Ca2+ regulation in guinea pig detrusor smooth muscle , 2001 .

[26]  A. Ford,et al.  A quantitative analysis of purinoceptor expression in the bladders of patients with symptomatic outlet obstruction , 2001, BJU international.

[27]  M. Yoshida,et al.  Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth muscles , 2001, Experimental Gerontology.

[28]  G. Burnstock,et al.  Distribution of P2X receptors in the urinary bladder and the ureter of the rat. , 2000, The Journal of urology.

[29]  D. Newgreen,et al.  A quantitative study of atropine-resistant contractile responses in human detrusor smooth muscle, from stable, unstable and obstructed bladders. , 1999, The Journal of urology.

[30]  P. Séguéla,et al.  Central P2X4 and P2X6 Channel Subunits Coassemble into a Novel Heteromeric ATP Receptor , 1998, The Journal of Neuroscience.

[31]  C. Kennedy,et al.  The ecto-ATPase inhibitor ARL 67156 enhances parasympathetic neurotransmission in the guinea-pig urinary bladder. , 1997, European journal of pharmacology.

[32]  O. Yamaguchi,et al.  Changes in cholinergic and purinergic neurotransmission in pathologic bladder of chronic spinal rabbit. , 1996, The Journal of urology.

[33]  G. L. Craviso,et al.  Evidence for the differential release of the cotransmitters ATP and noradrenaline from sympathetic nerves of the guinea‐pig vas deferens. , 1996, The Journal of physiology.

[34]  A. Akaike,et al.  Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes , 1996, Neuroscience Letters.

[35]  H. Hashitani,et al.  Electrical and mechanical responses produced by nerve stimulation in detrusor smooth muscle of the guinea-pig. , 1995, European journal of pharmacology.

[36]  S. Palea,et al.  Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis. , 1993, The Journal of urology.

[37]  G. Burnstock,et al.  Abnormalities of responses to autonomic stimulation in the mouse urinary bladder associated with Semliki Forest virus-induced demyelination. , 1989, The Journal of urology.

[38]  G. Burnstock,et al.  The contributions of noradrenaline and ATP to the responses of the rabbit central ear artery to sympathetic nerve stimulation depend on the parameters of stimulation. , 1986, European journal of pharmacology.

[39]  G. Burnstock,et al.  PURINERGIC INNERVATION OF THE GUINEA‐PIG URINARY BLADDER , 1978, British journal of pharmacology.

[40]  F. Bronson,et al.  Social Rank in House Mice: Differentiation Revealed by Ultraviolet Visualization of Urinary Marking Patterns , 1973, Science.

[41]  R. North.  P2X receptors , 2016, Philosophical Transactions of the Royal Society B: Biological Sciences.

[42]  C. Kennedy,et al.  Pharmacology of P2X receptors , 2012 .

[43]  R. Morgan,et al.  Changes in cholinergic and purinergic neurotransmission in the diabetic rabbit bladder. , 2006, In vivo.

[44]  R. Aldrich,et al.  The American Journal of Physiology- Regulatory, Integrative and Comparative Physiology publishes original investigations that , 2005 .

[45]  G. Burnstock,et al.  P2X receptors and their role in female idiopathic detrusor instability. , 2002, The Journal of urology.

[46]  R. North,et al.  Pharmacology of cloned P2X receptors. , 2000, Annual review of pharmacology and toxicology.

[47]  C. Fry,et al.  The action potential and net membrane currents in isolated human detrusor smooth muscle cells. , 1992, The Journal of urology.

[48]  J. Williams,et al.  Contractile responses of smooth muscle strips from rat and guinea-pig urinary bladder to transmural stimulation: effects of atropine and alpha,beta-methylene ATP. , 1990, British journal of pharmacology.

[49]  L. Noronha-Blob,et al.  Effects of selective cholinergic antagonists and alpha,beta-methylene ATP on guinea-pig urinary bladder contractions in vivo following pelvic nerve stimulation. , 1989, Journal of autonomic pharmacology.

[50]  W. Zontine.  The urinary bladder. , 1975, Modern veterinary practice.