How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?

[1]  M. Samara,et al.  Systematic review with meta‐analysis: The effect of vitamin E supplementation in adult patients with non‐alcoholic fatty liver disease , 2020, Journal of gastroenterology and hepatology.

[2]  H. Moshage,et al.  Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes. , 2020, Toxicology and applied pharmacology.

[3]  B. Schnabl,et al.  Microbiota and Fatty Liver Disease-the Known, the Unknown, and the Future. , 2020, Cell host & microbe.

[4]  G. Silecchia,et al.  Adipose tissue remodelling in obese subjects is a determinant of presence and severity of fatty liver disease , 2020, Diabetes/metabolism research and reviews.

[5]  Jingmin Zhao,et al.  Mitochondrial DNA from hepatocytes induces upregulation of interleukin-33 expression of macrophages in nonalcoholic steatohepatitis. , 2020, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[6]  G. Gores,et al.  Lytic Cell Death in Metabolic Liver Disease. , 2020, Journal of hepatology.

[7]  V. Wong,et al.  A new definition for metabolic associated fatty liver disease: an international expert consensus statement. , 2020, Journal of hepatology.

[8]  J. Banales,et al.  Extracellular Vesicles in NAFLD/ALD: From Pathobiology to Therapy , 2020, Cells.

[9]  Y. Hiasa,et al.  Advanced fibrosis of non-alcoholic steatohepatitis affects the significance of lipoprotein(a) as a cardiovascular risk factor. , 2020, Atherosclerosis.

[10]  J. Torres,et al.  Chemical hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles. , 2020, Biochimica et biophysica acta. Molecular basis of disease.

[11]  Z. Nwosu,et al.  Hepatocyte caveolin-1 modulates metabolic gene profiles and functions in non-alcoholic fatty liver disease , 2020, Cell Death & Disease.

[12]  K. Faber,et al.  Protective effect of metformin against palmitate-induced hepatic cell death. , 2019, Biochimica et biophysica acta. Molecular basis of disease.

[13]  G. Courtois,et al.  Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease. , 2019, Journal of hepatology.

[14]  R. Caesar,et al.  Dietary lipids, gut microbiota and lipid metabolism , 2019, Reviews in Endocrine and Metabolic Disorders.

[15]  T. Kadowaki,et al.  Hepatic FATP5 expression is associated with histological progression and loss of hepatic fat in NAFLD patients , 2019, Journal of Gastroenterology.

[16]  K. Cusi,et al.  Modulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease , 2019, Hepatology.

[17]  K. Tomita,et al.  Lipoprotein Lipase Up‐regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice , 2019, Hepatology communications.

[18]  Q. Tong,et al.  SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity , 2019, Cell Death & Differentiation.

[19]  P. Codogno,et al.  Autophagy in liver diseases: Time for translation? , 2019, Journal of hepatology.

[20]  W. Esler,et al.  Metabolic Targets in Nonalcoholic Fatty Liver Disease , 2019, Cellular and molecular gastroenterology and hepatology.

[21]  N. Petrovsky,et al.  Calcium Signaling As a Therapeutic Target for Liver Steatosis , 2019, Trends in Endocrinology & Metabolism.

[22]  A. Malhotra,et al.  Obstructive Sleep Apnea, Hypoxia, and Nonalcoholic Fatty Liver Disease , 2019, American journal of respiratory and critical care medicine.

[23]  Jian Wu,et al.  Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis , 2019, Laboratory Investigation.

[24]  N. Chalasani,et al.  Lipid mediators of liver injury in nonalcoholic fatty liver disease. , 2019, American journal of physiology. Gastrointestinal and liver physiology.

[25]  C. Morillas,et al.  Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity , 2018, Molecular metabolism.

[26]  C. Hetz,et al.  Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease. , 2018, Journal of hepatology.

[27]  T. Luedde,et al.  Apoptosis and necroptosis in the liver: a matter of life and death , 2018, Nature Reviews Gastroenterology & Hepatology.

[28]  N. Goda,et al.  HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver , 2018, Scientific Reports.

[29]  T. Asselah,et al.  Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases. , 2018, Gastroenterology.

[30]  E. Paschetta,et al.  Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis. , 2018, Gastroenterology.

[31]  P. Meikle,et al.  Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression[S] , 2018, Journal of Lipid Research.

[32]  P. Calder,et al.  The characterisation of hepatic mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD) using the 13C-ketoisocaproate breath test , 2018, Journal of breath research.

[33]  B. Neuschwander‐Tetri,et al.  Mechanisms of NAFLD development and therapeutic strategies , 2018, Nature Medicine.

[34]  C. Bocca,et al.  Hypoxia‐inducible factor 2α drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine‐rich glycoprotein , 2018, Hepatology.

[35]  Jingping Liu,et al.  Oleic acid protects saturated fatty acid mediated lipotoxicity in hepatocytes and rat of non‐alcoholic steatohepatitis , 2018, Life sciences.

[36]  Sharad Kumar,et al.  Caspases in metabolic disease and their therapeutic potential , 2018, Cell Death & Differentiation.

[37]  N. Kaplowitz,et al.  New insights into the role and mechanism of c‐Jun‐N‐terminal kinase signaling in the pathobiology of liver diseases , 2018, Hepatology.

[38]  K. Nadeau,et al.  Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. , 2018, Journal of hepatology.

[39]  W. Stremmel,et al.  Circulating Phospholipid Patterns in NAFLD Patients Associated with a Combination of Metabolic Risk Factors , 2018, Nutrients.

[40]  J. Banales,et al.  Pyroptosis: An inflammatory link between NAFLD and NASH with potential therapeutic implications. , 2018, Journal of hepatology.

[41]  B. Aronow,et al.  Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. , 2018, JCI insight.

[42]  C. Byrne,et al.  Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus , 2018, Nature Reviews Endocrinology.

[43]  M. Trauner,et al.  Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease. , 2018, Annual review of pathology.

[44]  Jun Yu,et al.  Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[45]  C. Byrne,et al.  Non-alcoholic fatty liver disease: A risk factor for myocardial dysfunction? , 2017, Journal of hepatology.

[46]  A. Vollmar,et al.  Mitochondrial adaptation in steatotic mice. , 2017, Mitochondrion.

[47]  R. Zechner,et al.  Cytosolic lipolysis and lipophagy: two sides of the same coin , 2017, Nature Reviews Molecular Cell Biology.

[48]  P. Puri,et al.  Liver Transplantation for Nonalcoholic Steatohepatitis in the US: Temporal Trends and Outcomes , 2017, Digestive Diseases and Sciences.

[49]  C. Geisler,et al.  Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones. , 2017, The Journal of endocrinology.

[50]  J. H. Kim,et al.  Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells , 2017, Scientific Reports.

[51]  A. Wree,et al.  Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis , 2017, Scientific Reports.

[52]  Youming Li,et al.  Caveolin1 protects against diet induced hepatic lipid accumulation in mice , 2017, PloS one.

[53]  J. Pépin,et al.  Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease , 2017, European Respiratory Journal.

[54]  C. Anania,et al.  The Role of Lipid and Lipoprotein Metabolism in Non-Alcoholic Fatty Liver Disease , 2017, Children.

[55]  L. Bolondi,et al.  A Relative Deficiency of Lysosomal Acid Lypase Activity Characterizes Non-Alcoholic Fatty Liver Disease , 2017, International journal of molecular sciences.

[56]  D. Samuel,et al.  Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients , 2017, Scientific Reports.

[57]  K. Faber,et al.  Prevalence and determinants of non-alcoholic fatty liver disease in lifelines: A large Dutch population cohort , 2017, PloS one.

[58]  N. Kaplowitz,et al.  Questions and controversies: the role of necroptosis in liver disease , 2016, Cell Death Discovery.

[59]  K. Clément,et al.  Systematic review of bariatric surgery liver biopsies clarifies the natural history of liver disease in patients with severe obesity , 2016, Gut.

[60]  C. Croniger,et al.  Receptor interacting protein 3 protects mice from high‐fat diet‐induced liver injury , 2016, Hepatology.

[61]  N. Kaplowitz,et al.  The many faces of RIPK3: What about NASH? , 2016, Hepatology.

[62]  Rohit Kohli,et al.  Lysosomal Acid Lipase Deficiency Unmasked in Two Children With Nonalcoholic Fatty Liver Disease , 2016, Pediatrics.

[63]  M. Orešič,et al.  Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites. , 2016, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[64]  K. Nakao,et al.  Lipotoxicity pathways intersect in hepatocytes: Endoplasmic reticulum stress, c‐Jun N‐terminal kinase‐1, and death receptors , 2016, Hepatology research : the official journal of the Japan Society of Hepatology.

[65]  A. Halbower,et al.  Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease. , 2016, Journal of hepatology.

[66]  A. Sanyal,et al.  Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease. , 2016, Metabolism: clinical and experimental.

[67]  R. Kaufman,et al.  The role of ER stress in lipid metabolism and lipotoxicity , 2016, Journal of Lipid Research.

[68]  A. Alisi,et al.  Reduced lysosomal acid lipase activity - A potential role in the pathogenesis of non alcoholic fatty liver disease in pediatric patients. , 2016, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[69]  K. Petersen,et al.  Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy. , 2016, Cell metabolism.

[70]  H. Izumi,et al.  Lipid-Induced Endoplasmic Reticulum Stress Impairs Selective Autophagy at the Step of Autophagosome-Lysosome Fusion in Hepatocytes. , 2016, The American journal of pathology.

[71]  Lily Q. Dong,et al.  Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator–Activated Receptor α , 2016, Diabetes.

[72]  G. Gores,et al.  Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis[S] , 2016, Journal of Lipid Research.

[73]  G. Gores,et al.  Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes. , 2016, Gastroenterology.

[74]  A. Papavassiliou,et al.  XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism , 2016, Trends in Endocrinology & Metabolism.

[75]  G. Gores,et al.  Mixed lineage kinase 3 mediates release of C‐X‐C motif ligand 10–bearing chemotactic extracellular vesicles from lipotoxic hepatocytes , 2016, Hepatology.

[76]  M. Yin,et al.  Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner[S] , 2016, Journal of Lipid Research.

[77]  D. Erion,et al.  Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice. , 2016, Endocrinology.

[78]  R. Premont,et al.  Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease , 2016, Cell Death and Disease.

[79]  M. Febbraio,et al.  The roles of c‐Jun NH2‐terminal kinases (JNKs) in obesity and insulin resistance , 2016, The Journal of physiology.

[80]  D. Burks,et al.  Hepatic lipase deficiency produces glucose intolerance, inflammation and hepatic steatosis. , 2015, The Journal of endocrinology.

[81]  H. Cortez‐Pinto,et al.  Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis. , 2015, Clinical science.

[82]  D. R. Laybutt,et al.  The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK , 2015, Molecular and Cellular Endocrinology.

[83]  A. P. Arruda,et al.  Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes. , 2015, Cell metabolism.

[84]  G. Labbadia,et al.  Reduced Lysosomal Acid Lipase Activity in Adult Patients With Non-alcoholic Fatty Liver Disease , 2015, EBioMedicine.

[85]  C. Trautwein,et al.  TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess. , 2015, Journal of hepatology.

[86]  Mats Fredrikson,et al.  Fibrosis stage is the strongest predictor for disease‐specific mortality in NAFLD after up to 33 years of follow‐up , 2015, Hepatology.

[87]  P. Flachs,et al.  Lipid signaling in adipose tissue: Connecting inflammation & metabolism. , 2015, Biochimica et biophysica acta.

[88]  Eoin Fahy,et al.  Biomarkers of NAFLD progression: a lipidomics approach to an epidemic1[S] , 2015, Journal of Lipid Research.

[89]  C. Mulligan,et al.  The role of visceral and subcutaneous adipose tissue fatty acid composition in liver pathophysiology associated with NAFLD , 2015, Adipocyte.

[90]  G. Gores,et al.  Death Receptor-Mediated Cell Death and Proinflammatory Signaling in Nonalcoholic Steatohepatitis , 2014, Cellular and molecular gastroenterology and hepatology.

[91]  G. Karaca,et al.  Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis , 2014, Gut.

[92]  Florian Reisinger,et al.  RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction. , 2014, Cardiovascular research.

[93]  Á. Valverde,et al.  Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD , 2014, Cell Death and Disease.

[94]  Yasushi Noguchi,et al.  Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes. , 2014, Metabolism: clinical and experimental.

[95]  J. Seong,et al.  Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low‐density lipoprotein receptor , 2013, Hepatology.

[96]  G. Hirokawa,et al.  Pex11α deficiency impairs peroxisome elongation and division and contributes to nonalcoholic fatty liver in mice. , 2013, American journal of physiology. Endocrinology and metabolism.

[97]  G. Gores,et al.  A hedgehog survival pathway in 'undead' lipotoxic hepatocytes. , 2012, Journal of hepatology.

[98]  G. López,et al.  Hepatic lipase activity is increased in non‐alcoholic fatty liver disease beyond insulin resistance , 2012, Diabetes/metabolism research and reviews.

[99]  S. Sookoian,et al.  Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease , 2012, Gut.

[100]  P. Marchetti,et al.  Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis , 2012, Diabetes.

[101]  D. R. Laybutt,et al.  Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistance. , 2012, Endocrinology.

[102]  J. Browning,et al.  Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. , 2011, Cell metabolism.

[103]  A. Dolganiuc,et al.  Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells , 2011, Hepatology.

[104]  J. Mauer,et al.  Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance* , 2009, The Journal of Biological Chemistry.

[105]  S. Watkins,et al.  The plasma lipidomic signature of nonalcoholic steatohepatitis , 2009, Hepatology.

[106]  M. Yarmush,et al.  Steatosis reversibly increases hepatocyte sensitivity to hypoxia-reoxygenation injury. , 2009, The Journal of surgical research.

[107]  M. Czaja,et al.  Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance , 2009, Hepatology.

[108]  M. Furuhashi,et al.  Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets , 2008, Nature Reviews Drug Discovery.

[109]  G. Gores,et al.  The lysosomal‐mitochondrial axis in free fatty acid–induced hepatic lipotoxicity , 2008, Hepatology.

[110]  B. S. Mohammed,et al.  Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. , 2008, Gastroenterology.

[111]  Michelle M Wiest,et al.  A lipidomic analysis of nonalcoholic fatty liver disease , 2007, Hepatology.

[112]  M. Newell,et al.  Endogenous versus exogenous fatty acid availability affects lysosomal acidity and MHC class II expression Published, JLR Papers in Press, August 16, 2006. , 2006, Journal of Lipid Research.

[113]  J. Jessurun,et al.  Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. , 2005, The Journal of clinical investigation.

[114]  G. Gores,et al.  Free fatty acids promote hepatic lipotoxicity by stimulating TNF‐α expression via a lysosomal pathway , 2004 .

[115]  G. Gores,et al.  O0040 FREE FATTY ACIDS PROMOTE HEPATIC LIPOTOXICITY BY STIMULATING TNF‐ALPHA EXPRESSION VIA A LYSOSOMAL PATHWAY , 2004, Journal of Pediatric Gastroenterology and Nutrition.

[116]  G. Marchesini,et al.  Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: Implications for Liver Transplantation. , 2019, Transplantation.

[117]  S. Klein,et al.  Physiological Mechanisms of Weight Gain-Induced Steatosis in People With Obesity. , 2016, Gastroenterology.

[118]  G. Gores,et al.  Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[119]  D. Rozman,et al.  Review Article Nonalcoholic Fatty Liver Disease: Focus on Lipoprotein and Lipid Deregulation , 2022 .