Mass Screening Models for Contagious Diseases with No Latent Period

In this paper, a simplified model describing the stochastic process underlying the etiology of contagious and noncontagious diseases with mass screening is developed. Typical examples might include screening of tuberculosis in urban ghetto areas, venereal diseases in the sexually active, or AIDS in high risk population groups. The model is addressed to diseases which have zero or negligible latent periods. In the model, it is assumed that the reliabilities of the screening tests are constant, and independent of how long the population unit has the disease. Both tests with perfect and imperfect reliabilities are considered. It is shown that most of the results of a 1978 study by W.P. Pierskalla and J.A. Voelker for noncontagious diseases can be generalized for contagious diseases. A mathematical program for computing the optimal test choice and screening periods is presented. It is shown that the optimal screening schedule is equally spaced for tests with perfect reliability. Other properties relating to the managerial problems of screening frequencies, test selection, and resource allocation are also presented.

[1]  M. Klein,et al.  Examination schedules for breast cancer , 1974, Cancer.

[2]  Michael Shwartz,et al.  A Mathematical Model Used to Analyze Breast Cancer Screening Strategies , 1978, Oper. Res..

[3]  William P. Pierskalla,et al.  A survey of maintenance models: The control and surveillance of deteriorating systems , 1976 .

[4]  A. M'Kendrick Applications of Mathematics to Medical Problems , 1925, Proceedings of the Edinburgh Mathematical Society.

[5]  M Zelen,et al.  Some pitfalls in the evaluation of screening programs. , 1969, Archives of environmental health.

[6]  M. Shwartz,et al.  An analysis of the benefits of serial screening for breast cancer based upon a mathematical model of the disease , 1978, Cancer.

[7]  William P. Pierskalla,et al.  Test selection for a mass screeening program , 1980 .

[8]  G. Ejlertsson,et al.  Continuity-of-Care Measures: An Analytic and Empirical Comparison , 1984, Medical care.

[9]  Bennett Fox,et al.  Discrete Optimization Via Marginal Analysis , 1966 .

[10]  Irwin D. J. Bross,et al.  Screening random asymptomatic women under 50 by annual mammographies: Does it make sense? , 1976 .

[11]  N. Ling The Mathematical Theory of Infectious Diseases and its applications , 1978 .

[12]  W. R. Buckland,et al.  Stochastic Models for Social Processes , 1967 .

[13]  Leslie E. Blumenson,et al.  Compromise screening strategies for chronic disease , 1977 .

[14]  Sanders Jl,et al.  Quantitative guidelines for communicable disease control programs. , 1971 .

[15]  Philip C. Prorok,et al.  The theory of periodic screening I: Lead time and proportion detected , 1976, Advances in Applied Probability.

[16]  Philip C. Prorok,et al.  The theory of periodic screening II: doubly bounded recurrence times and mean lead time and detection probability estimation , 1976, Advances in Applied Probability.

[17]  Marvin Zelen,et al.  On the theory of screening for chronic diseases , 1969 .

[18]  Morton Klein,et al.  Surveillance Schedules for Medical Examinations , 1974 .

[19]  P. Curtis,et al.  The concept and measurement of continuity in primary care. , 1980, American journal of public health.

[20]  William P. Pierskalla,et al.  A Model for Optimal Mass Screening and the Case of Perfect Test Reliability. , 1976 .

[21]  J. McCall Maintenance Policies for Stochastically Failing Equipment: A Survey , 1965 .

[22]  M. S. Bartlett,et al.  Some Evolutionary Stochastic Processes , 1949 .

[23]  J. Kiefer,et al.  An Introduction to Stochastic Processes. , 1956 .

[24]  S M Shortell,et al.  Continuity of Medical Care: Conceptualization and Measurement , 1976, Medical care.