Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, finding important new information about the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes and around brain-expressed regulatory marks. Analyses of three replication studies: a cohort of individuals diagnosed with ADHD, a self-reported ADHD sample and a meta-analysis of quantitative measures of ADHD symptoms in the population, support these findings while highlighting study-specific differences on genetic overlap with educational attainment. Strong concordance with GWAS of quantitative population measures of ADHD symptoms supports that clinical diagnosis of ADHD is an extreme expression of continuous heritable traits.A genome-wide association study for attention deficit/hyperactivity disorder (ADHD) identifies 12 loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.

Alicia R. Martin | N. Eriksson | M. Daly | A. Auton | D. Geschwind | H. Stefánsson | B. Franke | O. Andreassen | M. Rietschel | T. Werge | K. Stefánsson | V. Vacic | M. Owen | P. Sullivan | R. Anney | C. Freitag | H. Hakonarson | B. Alipanahi | K. Bryc | B. Neale | S. Ring | P. Holmans | N. Timpson | S. Shringarpure | K. Lesch | J. Maller | R. Ebstein | N. Martin | L. Rohde | E. Grevet | S. Dalsgaard | M. Hutz | J. Buitelaar | Yufeng Wang | R. Plomin | J. McGough | S. Faraone | J. Tung | J. Mountain | P. Sklar | N. Williams | K. Chambert | J. Biederman | D. Boomsma | J. Sergeant | D. Nyholt | J. Sunyer | J. Hottenga | N. Furlotte | E. Mick | G. Walters | E. Krapohl | B. Herpertz-Dahlmann | T. Banaschewski | S. Smalley | O. Mors | S. Hohmann | R. Oades | P. Mortensen | A. Børglum | M. Nordentoft | D. Hougaard | M. Mattheisen | S. Medland | M. Wright | J. Goldstein | D. Howrigan | C. Stevens | S. Ripke | J. Moran | A. Rothenberger | J. Hebebrand | A. Hinney | J. Kemp | J. Hudziak | H. Tiemeier | A. Jugessur | R. Myhre | M. Arranz | J. Ormel | C. Hartman | I. Nolte | J. Grove | T. Als | P. Fontanillas | S. Walitza | J. Gelernter | A. Warnke | G. Lehmkuhl | A. Thapar | B. Cormand | C. Sánchez-Mora | J. Ramos-Quiroga | M. Ribasés | C. Stoltenberg | E. Sonuga-Barke | R. Walters | I. Fedko | G. Davies | A. Scherag | S. Johansson | C. Pennell | Carol A. Wang | E. Thiering | K. Langley | C. Middeldorp | S. Kittel-Schneider | T. Poterba | D. Demontis | Joanna Martin | E. Agerbo | G. Baldursson | R. Belliveau | J. Bybjerg-Grauholm | M. Bækvad-Hansen | Felecia Cerrato | C. Churchhouse | Ashle Dumont | M. Gandal | K. Grasby | O. Gudmundsson | C. Hansen | M. Hauberg | M. Hollegaard | Hailiang Huang | J. Pallesen | D. Palmer | C. Pedersen | M. Pedersen | J. B. Poulsen | E. Robinson | F. Satterstrom | P. Turley | H. Won | P. Asherson | C. Burton | J. Haavik | H. Kranzler | J. Kuntsi | A. Reif | P. Roussos | R. Schachar | I. Waldman | H. Steinhausen | A. Doyle | N. R. Mota | S. Witt | B. Pourcain | A. Hervás | M. Murcia | M. Standl | A. Kleinman | S. Loo | N. Vilor-Tejedor | C. Tian | T. Renner | S. Pitts | S. Elson | N. Litterman | M. Romanos | Jobst Meyer | M. Trzaskowski | J. Shelton | M. Casas | J. Crosbie | J. Elia | L. Kent | A. Miranda | A. Todorov | E. Stergiakouli | A. Hammerschlag | J. Sathirapongsasuti | M. McIntyre | E. Ehli | Bethann S. Hromatka | C. Tiesler | M. Guxens | Z. Hawi | B. Schimmelmann | T. Zayats | A. Dempfle | O. Rivero | H. Pálmason | Claiton H.D. Bau | P. J. Most | Li Yang | A. Charach | M. Groen-Blokhuis | M. Agee | R. Bell | K. Huber | C. Northover | C. Greven | I. Pappa | A. Mulligan | F. Mulas | J. Sinzig | Ö. Albayrak | H. Schäfer | M. Föcker | Katrina L. Grasby | Huiying Zhao | J. Romanos | Carla M. T. Tiesler | Anke R. Hammerschlag | N. Lambregts-Rommelse | A. Whitehouse | K. Ouwens | G. D. Smith | David M. Evans | A. Vasquez | M. Gill | O. V. Sazonova | D. Hinds | J. Poulsen | C. H. Wilson | C. Wilson | O. Sazonova | D. Evans | Michael C. O’Donovan | Abel Ickowitz | Frank Middletion | Joachim Heinrich | T. Nguyen | J. Heinrich | N. Martin | M. Wright | M. Thompson | Freimer Nelson | Herbert Royers | Zhang Yanli | D. Boomsma | M. Thompson | Andrew J. O. Whitehouse | M. Wright | M. O’Donovan | N. Martin | Eva Krapohl | N. Martin | Marie Bækvad-Hansen | N. Martin | Olafur O. Gudmundsson | M. Pedersen | Jonatan Pallesen | Ronny Myhre | B. S. Pourcain | Nanda N. J. Lambregts-Rommelse | M. Mcintyre | K. G. Ouwens | Ashley L. Dumont | E. Robinson

[1]  F. Yates.  Contingency Tables Involving Small Numbers and the χ2 Test , 1934 .

[2]  Joseph Biederman,et al.  Intellectual performance and school failure in children with attention deficit hyperactivity disorder and in their siblings. , 1993, Journal of abnormal psychology.

[3]  S. Faraone,et al.  Do attention deficit hyperactivity disorder and major depression share familial risk factors? , 1997, The Journal of nervous and mental disease.

[4]  Yu-Shin Ding,et al.  Therapeutic Doses of Oral Methylphenidate Significantly Increase Extracellular Dopamine in the Human Brain , 2001, The Journal of Neuroscience.

[5]  Yun-ping Zhu,et al.  Identification, Characterization, and Functional Study of the Two Novel Human Members of the Semaphorin Gene Family* 210 , 2002, The Journal of Biological Chemistry.

[6]  J S Fowler,et al.  Mechanism of action of methylphenidate: Insights from PET imaging studies , 2002, Journal of attention disorders.

[7]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Ali A. Bonab,et al.  In Vivo Neuroreceptor Imaging in Attention-Deficit/Hyperactivity Disorder: A Focus on The Dopamine Transporter , 2005, Biological Psychiatry.

[9]  S. Faraone,et al.  Attention-deficit hyperactivity disorder , 2005, The Lancet.

[10]  J. Smoller,et al.  Molecular Genetics of Attention-Deficit/Hyperactivity Disorder , 2005, Biological Psychiatry.

[11]  D. Reich,et al.  Principal components analysis corrects for stratification in genome-wide association studies , 2006, Nature Genetics.

[12]  B. Molina,et al.  Childhood ADHD Predicts Risky Sexual Behavior in Young Adulthood , 2006, Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53.

[13]  R. Barkley,et al.  ADHD in Adults: What the Science Says , 2007 .

[14]  B. Franke,et al.  Co-transmission of conduct problems with attention-deficit/hyperactivity disorder: familial evidence for a distinct disorder , 2008, Journal of Neural Transmission.

[15]  B. Horta,et al.  The worldwide prevalence of ADHD: a systematic review and metaregression analysis. , 2007, The American journal of psychiatry.

[16]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[17]  W. Barbaresi,et al.  Long-Term School Outcomes for Children with Attention-Deficit/Hyperactivity Disorder: A Population-Based Perspective , 2007, Journal of developmental and behavioral pediatrics : JDBP.

[18]  D. Geschwind,et al.  Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. , 2007, American journal of human genetics.

[19]  S. Amara,et al.  Genetic complementation screen identifies a mitogen-activated protein kinase phosphatase, MKP3, as a regulator of dopamine transporter trafficking. , 2008, Molecular biology of the cell.

[20]  G. Abecasis,et al.  Genotype imputation. , 2009, Annual review of genomics and human genetics.

[21]  R. Plomin,et al.  Rethinking environmental contributions to child and adolescent psychopathology: a meta-analysis of shared environmental influences. , 2009, Psychological bulletin.

[22]  S. Auvin,et al.  MEF2C haploinsufficiency caused by either microdeletion of the 5q14.3 region or mutation is responsible for severe mental retardation with stereotypic movements, epilepsy and/or cerebral malformations , 2009, Journal of Medical Genetics.

[23]  D. Boomsma,et al.  Maternal ratings of attention problems in ADHD: evidence for the existence of a continuum. , 2009, Journal of the American Academy of Child and Adolescent Psychiatry.

[24]  J. Owens.  A clinical overview of sleep and attention-deficit/hyperactivity disorder in children and adolescents. , 2009, Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent.

[25]  P. Visscher,et al.  Common polygenic variation contributes to risk of schizophrenia and bipolar disorder , 2009, Nature.

[26]  N. Sobreira,et al.  Interstitial deletion 5q14.3‐q21 associated with iris coloboma, hearing loss, dental anomaly, moderate intellectual disability, and attention deficit and hyperactivity disorder , 2009, American journal of medical genetics. Part A.

[27]  E. Ortibus,et al.  Refining the phenotype associated with MEF2C haploinsufficiency , 2010, Clinical genetics.

[28]  Jan K. Buitelaar,et al.  Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder , 2010, European Child & Adolescent Psychiatry.

[29]  Henrik,et al.  Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index , 2012 .

[30]  P. Newacheck,et al.  Prevalence of Obesity Among Children With Chronic Conditions , 2010, Obesity.

[31]  G. Salmon,et al.  Attention deficit hyperactivity disorder. , 2018, British journal of hospital medicine.

[32]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[33]  Tanya M. Teslovich,et al.  Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index , 2010 .

[34]  Tanya M. Teslovich,et al.  Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids , 2010, Nature.

[35]  Ming D. Li,et al.  Genome-wide meta-analyses identify multiple loci associated with smoking behavior , 2010, Nature Genetics.

[36]  Susanne Walitza,et al.  Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. , 2010, Journal of the American Academy of Child and Adolescent Psychiatry.

[37]  K. Humphreys,et al.  Prospective association of childhood attention-deficit/hyperactivity disorder (ADHD) and substance use and abuse/dependence: a meta-analytic review. , 2011, Clinical psychology review.

[38]  Wei Chen,et al.  ST3GAL3 mutations impair the development of higher cognitive functions. , 2011, American journal of human genetics.

[39]  N. Halfon,et al.  Patterns of Comorbidity, Functioning, and Service Use for US Children With ADHD, 2007 , 2011, Pediatrics.

[40]  P. Visscher,et al.  GCTA: a tool for genome-wide complex trait analysis. , 2011, American journal of human genetics.

[41]  Kay E. Davies,et al.  Foxp2 Regulates Gene Networks Implicated in Neurite Outgrowth in the Developing Brain , 2011, PLoS genetics.

[42]  Albert J. Vilella,et al.  A high-resolution map of human evolutionary constraint using 29 mammals , 2011, Nature.

[43]  J. Marchini,et al.  Genotype Imputation with Thousands of Genomes , 2011, G3: Genes | Genomes | Genetics.

[44]  B. Franke,et al.  The genetics of attention deficit/hyperactivity disorder in adults, a review , 2011, Molecular Psychiatry.

[45]  Inês Barroso,et al.  A genome-wide association meta-analysis identifies new childhood obesity loci , 2012, Nature Genetics.

[46]  S. Faraone,et al.  Examining the comorbidity between attention deficit hyperactivity disorder and bipolar I disorder: a meta-analysis of family genetic studies. , 2012, The American journal of psychiatry.

[47]  Bronwen L. Aken,et al.  GENCODE: The reference human genome annotation for The ENCODE Project , 2012, Genome research.

[48]  L. Bauer,et al.  Attention deficit hyperactivity symptoms and risky sexual behavior in young adult women , 2012 .

[49]  Jake K. Byrnes,et al.  Bayesian refinement of association signals for 14 loci in 3 common diseases , 2012, Nature Genetics.

[50]  A. Sjölander,et al.  Medication for attention deficit-hyperactivity disorder and criminality. , 2012, The New England journal of medicine.

[51]  P. Lichtenstein,et al.  Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs. , 2012, Journal of child psychology and psychiatry, and allied disciplines.

[52]  Tanya M. Teslovich,et al.  Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes , 2012, Nature Genetics.

[53]  O. Delaneau,et al.  A linear complexity phasing method for thousands of genomes , 2011, Nature Methods.

[54]  Intravenous immune globulin in autoimmune and inflammatory diseases. , 2013, The New England journal of medicine.

[55]  D. Kaplan,et al.  FoxP2 Regulates Neurogenesis during Embryonic Cortical Development , 2013, The Journal of Neuroscience.

[56]  B. Franke,et al.  High Loading of Polygenic Risk for ADHD in Children With Comorbid Aggression , 2013, The American journal of psychiatry.

[57]  C. Vaegter,et al.  Sortilin-Related Receptor SORCS3 Is a Postsynaptic Modulator of Synaptic Depression and Fear Extinction , 2013, PloS one.

[58]  P. Lichtenstein,et al.  Risk of bipolar disorder and schizophrenia in relatives of people with attention-deficit hyperactivity disorder , 2013, British Journal of Psychiatry.

[59]  S. Keyse,et al.  Dual-specificity MAP kinase phosphatases (MKPs) , 2013, The FEBS journal.

[60]  Jianxin Shi,et al.  Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs , 2013, Nature Genetics.

[61]  Jonathan P. Beauchamp,et al.  GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment , 2013, Science.

[62]  S. Cortese,et al.  Attention-deficit/hyperactivity disorder and impairment in executive functions: a barrier to weight loss in individuals with obesity? , 2013, BMC Psychiatry.

[63]  Sarah E. Medland,et al.  Genome-Wide Association Study of Inattention and Hyperactivity–Impulsivity Measured as Quantitative Traits , 2013, Twin Research and Human Genetics.

[64]  R. Huganir,et al.  The Human Language–Associated Gene SRPX2 Regulates Synapse Formation and Vocalization in Mice , 2013, Science.

[65]  Nick C Fox,et al.  Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease , 2013, Nature Genetics.

[66]  Intravenous immune globulin in autoimmune and inflammatory diseases. , 2013, The New England journal of medicine.

[67]  N. Halfon,et al.  Associations between obesity and comorbid mental health, developmental, and physical health conditions in a nationally representative sample of US children aged 10 to 17. , 2013, Academic pediatrics.

[68]  O. Mortensen.  MKP3 eliminates depolarization-dependent neurotransmitter release through downregulation of L-type calcium channel Cav1.2 expression. , 2013, Cell calcium.

[69]  Jun Li,et al.  Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome‐wide association study of both common and rare variants , 2013, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[70]  M. Daly,et al.  Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis , 2013, The Lancet.

[71]  Ellen T. Gelfand,et al.  The Genotype-Tissue Expression (GTEx) project , 2013, Nature Genetics.

[72]  M. Gill,et al.  Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia , 2013, British Journal of Psychiatry.

[73]  Christian Gieger,et al.  Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture , 2013, Nature Genetics.

[74]  William Wheeler,et al.  Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer , 2014, Nature Genetics.

[75]  C. Spencer,et al.  Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.

[76]  Zoltán Kutalik,et al.  Quality control and conduct of genome-wide association meta-analyses , 2014, Nature Protocols.

[77]  J. Thome,et al.  Adult ADHD and suicide , 2014, ADHD Attention Deficit and Hyperactivity Disorders.

[78]  M. O’Donovan,et al.  Genetic Risk for Attention-Deficit/Hyperactivity Disorder Contributes to Neurodevelopmental Traits in the General Population , 2014, Biological Psychiatry.

[79]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[80]  A. Sjölander,et al.  Serious transport accidents in adults with attention-deficit/hyperactivity disorder and the effect of medication: a population-based study. , 2014, JAMA psychiatry.

[81]  A. Sjölander,et al.  Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study. , 2014, International journal of epidemiology.

[82]  P. Visscher,et al.  Childhood intelligence is heritable, highly polygenic and associated with FNBP1L , 2014, Molecular Psychiatry.

[83]  M. Frydenberg,et al.  ADHD, stimulant treatment in childhood and subsequent substance abuse in adulthood - a naturalistic long-term follow-up study. , 2014, Addictive behaviors.

[84]  Ian J. Deary,et al.  Common genetic variants associated with cognitive performance identified using the proxy-phenotype method , 2014, Proceedings of the National Academy of Sciences.

[85]  H. Steinhausen,et al.  Comorbid mental disorders in children and adolescents with attention-deficit/hyperactivity disorder in a large nationwide study , 2015, ADHD Attention Deficit and Hyperactivity Disorders.

[86]  T. Price,et al.  The Separation of ADHD Inattention and Hyperactivity-Impulsivity Symptoms: Pathways from Genetic Effects to Cognitive Impairments and Symptoms , 2012, Journal of abnormal child psychology.

[87]  S. Dalsgaard,et al.  Consequences of ADHD Medication Use for Children's Outcomes , 2014, Journal of health economics.

[88]  B. Neale,et al.  Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children. , 2014, Journal of the American Academy of Child and Adolescent Psychiatry.

[89]  C. A. French,et al.  Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance , 2014, Proceedings of the National Academy of Sciences.

[90]  Juancarlos Chan,et al.  Gene Ontology Consortium: going forward , 2014, Nucleic Acids Res..

[91]  J. Norvilitis,et al.  ADHD Symptomatology, Fear of Intimacy, and Sexual Anxiety and Behavior Among College Students in China and the United States , 2015, Journal of attention disorders.

[92]  S. Djurovic,et al.  Genome-Wide Analysis of Attention Deficit Hyperactivity Disorder in Norway , 2015, PloS one.

[93]  Gabor T. Marth,et al.  A global reference for human genetic variation , 2015, Nature.

[94]  S. Dalsgaard,et al.  Effect of drugs on the risk of injuries in children with attention deficit hyperactivity disorder: a prospective cohort study. , 2015, The lancet. Psychiatry.

[95]  V. Lehti,et al.  Parental age and the risk of attention-deficit/hyperactivity disorder: a nationwide, population-based cohort study. , 2015, Journal of the American Academy of Child and Adolescent Psychiatry.

[96]  Manolis Kellis,et al.  Large-scale epigenome imputation improves data quality and disease variant enrichment , 2015, Nature biotechnology.

[97]  Tamara S. Roman,et al.  New genetic loci link adipose and insulin biology to body fat distribution , 2014, Nature.

[98]  G. Kempermann.  Faculty Opinions recommendation of Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. , 2015 .

[99]  T. Cummins,et al.  The molecular genetic architecture of attention deficit hyperactivity disorder , 2015, Molecular Psychiatry.

[100]  Carson C Chow,et al.  Second-generation PLINK: rising to the challenge of larger and richer datasets , 2014, GigaScience.

[101]  Yakir A Reshef,et al.  Partitioning heritability by functional annotation using genome-wide association summary statistics , 2015, Nature Genetics.

[102]  C. Ponting,et al.  Disruption of Visc-2, a Brain-Expressed Conserved Long Noncoding RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype , 2014, Cerebral cortex.

[103]  M. Daly,et al.  LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.

[104]  Manolis Kellis,et al.  Large-scale epigenome imputation improves data quality and disease variant enrichment , 2015, Nature Biotechnology.

[105]  Jun S. Liu,et al.  The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans , 2015, Science.

[106]  S. Dalsgaard,et al.  Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study , 2015, The Lancet.

[107]  M. Daly,et al.  An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.

[108]  Gabor T. Marth,et al.  An integrated map of structural variation in 2,504 human genomes , 2015, Nature.

[109]  W. van den Brink,et al.  The Role of Different Aspects of Impulsivity as Independent Risk Factors for Substance Use Disorders in Patients with ADHD: A Review. , 2015, Current drug abuse reviews.

[110]  Joris M. Mooij,et al.  MAGMA: Generalized Gene-Set Analysis of GWAS Data , 2015, PLoS Comput. Biol..

[111]  Jan K. Buitelaar,et al.  Attention-deficit/hyperactivity disorder , 2015, Nature Reviews Disease Primers.

[112]  Michael Q. Zhang,et al.  Integrative analysis of 111 reference human epigenomes , 2015, Nature.

[113]  F. Cunningham,et al.  The Ensembl Variant Effect Predictor , 2016, Genome Biology.

[114]  Sayan Mukherjee,et al.  Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. , 2016, American journal of human genetics.

[115]  Daning Lu,et al.  Chromosome conformation elucidates regulatory relationships in developing human brain , 2016, Nature.

[116]  C. Amos,et al.  Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk. , 2016, Cancer research.

[117]  Jonathan P. Beauchamp,et al.  Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism , 2015, bioRxiv.

[118]  James Y. Zou.  Analysis of protein-coding genetic variation in 60,706 humans , 2015, Nature.

[119]  David M. Evans,et al.  A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts. , 2016, Journal of the American Academy of Child and Adolescent Psychiatry.

[120]  Luigi Ferrucci,et al.  Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants , 2016, bioRxiv.

[121]  D. Hinds,et al.  Identification of 15 genetic loci associated with risk of major depression in individuals of European descent , 2016, Nature Genetics.

[122]  Jonathan P. Beauchamp,et al.  Genome-wide association study identifies 74 loci associated with educational attainment , 2016, Nature.

[123]  L. Rohde,et al.  Association Between ADHD and Obesity: A Systematic Review and Meta-Analysis. , 2015, The American journal of psychiatry.

[124]  Stuart J. Ritchie,et al.  Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151) , 2016, Molecular Psychiatry.

[125]  I. Annesi-Maesano,et al.  Relationship between early language skills and the development of inattention/hyperactivity symptoms during the preschool period: Results of the EDEN mother-child cohort , 2016, BMC Psychiatry.

[126]  Jonathan P. Beauchamp,et al.  Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses , 2016, Nature Genetics.

[127]  N. Eriksson,et al.  Genome-wide analysis identifies 12 loci influencing human reproductive behavior , 2016 .

[128]  H. Stefánsson,et al.  Selection against variants in the genome associated with educational attainment , 2017, Proceedings of the National Academy of Sciences.

[129]  Robert Plomin,et al.  Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence , 2017, Nature Genetics.

[130]  P. Visscher,et al.  Multi-trait analysis of genome-wide association summary statistics using MTAG , 2017, Nature Genetics.

[131]  H. Stefánsson,et al.  Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits , 2017, Nature Genetics.

[132]  A. Hofman,et al.  Identification of context-dependent expression quantitative trait loci in whole blood , 2016, Nature Genetics.

[133]  Tom R. Gaunt,et al.  LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis , 2016, bioRxiv.

[134]  S. Dalsgaard,et al.  Teenage Parenthood and Birth Rates for Individuals With and Without Attention-Deficit/Hyperactivity Disorder: A Nationwide Cohort Study. , 2017, Journal of the American Academy of Child and Adolescent Psychiatry.

[135]  Jakob Grove,et al.  Common risk variants identified in autism spectrum disorder , 2017, bioRxiv.

[136]  P. Visscher,et al.  MTAG: Multi-Trait Analysis of GWAS , 2017, bioRxiv.

[137]  Raymond Walters,et al.  Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa. , 2017, The American journal of psychiatry.

[138]  Nick C Fox,et al.  Analysis of shared heritability in common disorders of the brain , 2018, Science.

[139]  Warren W. Kretzschmar,et al.  Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression , 2017, Nature Genetics.

[140]  B. Franke,et al.  The familial co-aggregation of ASD and ADHD: a register-based cohort study , 2017, Molecular Psychiatry.