Induction of caspase-independent apoptotic-like cell death of mouse mammary tumor TA3Ha cells in vitro and reduction of their lethality in vivo by the novel chemotherapeutic agent GIT-27NO.

[1]  M. Donia,et al.  The novel NO-donating compound GIT-27NO inhibits in vivo growth of human prostate cancer cells and prevents murine immunoinflammatory hepatitis. , 2009, European journal of pharmacology.

[2]  Xin-chun Fu,et al.  Acute, subacute toxicity and genotoxic effect of Bio-Quinone Q10 in mice and rats. , 2009, Regulatory toxicology and pharmacology : RTP.

[3]  M. Donia,et al.  Novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO) induces p53 mediated apoptosis in human A375 melanoma cells. , 2008, Nitric oxide : biology and chemistry.

[4]  B. Rigas,et al.  NO-donating NSAIDs and cancer: an overview with a note on whether NO is required for their action. , 2008, Nitric oxide : biology and chemistry.

[5]  F. Nicoletti,et al.  Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo , 2008, Molecular Cancer Therapeutics.

[6]  K. Kashfi,et al.  The mechanism of action of nitric oxide-donating aspirin. , 2007, Biochemical and biophysical research communications.

[7]  E. Mazzon,et al.  In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. , 2007, Clinical immunology.

[8]  Fuqin Guan,et al.  Nitric oxide and bcl-2 mediated the apoptosis induced by nickel(II) in human T hybridoma cells. , 2007, Toxicology and applied pharmacology.

[9]  Alexander Tsertsvadze,et al.  The Use of Aspirin for Primary Prevention of Colorectal Cancer: A Systematic Review Prepared for the U.S. Preventive Services Task Force , 2007, Annals of Internal Medicine.

[10]  F. Nicoletti,et al.  A Potent Immunomodulatory Compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxasole Acetic Acid, Prevents Spontaneous and Accelerated Forms of Autoimmune Diabetes in NOD Mice and Inhibits the Immunoinflammatory Diabetes Induced by Multiple Low Doses of Streptozotocin in CBA/H Mice , 2007, Journal of Pharmacology and Experimental Therapeutics.

[11]  Y. Yoo,et al.  Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells , 2006, Molecular Cancer Therapeutics.

[12]  B. Bonavida,et al.  Therapeutic potential of nitric oxide in cancer. , 2006, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[13]  Jianjun Gao,et al.  Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[14]  D. Chopin,et al.  Evaluation of the antitumoral potential of different nitric oxide-donating non-steroidal anti-inflammatory drugs (NO-NSAIDs) on human urological tumor cell lines. , 2005, Cancer letters.

[15]  K. Kashfi,et al.  Nitric-oxide-donating NSAIDs as agents for cancer prevention. , 2004, Trends in molecular medicine.

[16]  B. Mignotte,et al.  p53 can promote mitochondria- and caspase-independent apoptosis , 2004, Cell Death and Differentiation.

[17]  V. Trajković,et al.  Aloe-emodin prevents cytokine-induced tumor cell death: the inhibition of auto-toxic nitric oxide release as a potential mechanism , 2004, Cellular and Molecular Life Sciences CMLS.

[18]  F. Sobrino,et al.  Nitric oxide-induced carbonylation of Bcl-2, GAPDH and ANT precedes apoptotic events in insulin-secreting RINm5F cells. , 2004, Experimental cell research.

[19]  Wei Hong Wang,et al.  Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: a systematic review and meta-analysis. , 2003, Journal of the National Cancer Institute.

[20]  Michael Berger,et al.  Apoptosis - the p53 network , 2003, Journal of Cell Science.

[21]  M. Oren,et al.  Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation , 2003, Cell Death and Differentiation.

[22]  F. Traganos,et al.  Nitric Oxide-Donating Nonsteroidal Anti-Inflammatory Drugs Inhibit the Growth of Various Cultured Human Cancer Cells: Evidence of a Tissue Type-Independent Effect , 2002, Journal of Pharmacology and Experimental Therapeutics.

[23]  J. Lotem,et al.  Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[24]  G. Gores,et al.  Nitric oxide inhibits apoptosis downstream of cytochrome C release by nitrosylating caspase 9. , 2002, Cancer research.

[25]  Lily Y. Li,et al.  Action of Recombinant Human Apoptotic Endonuclease G on Naked DNA and Chromatin Substrates , 2001, The Journal of Biological Chemistry.

[26]  E. Neugebauer,et al.  Identification of a nitric oxide-regulated zinc finger containing transcription factor using motif-directed differential display. , 2000, Biochimica et biophysica acta.

[27]  J. Roth,et al.  Up-regulation of the proapoptotic mediators Bax and Bak after adenovirus-mediated p53 gene transfer in lung cancer cells. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[28]  E. Stavridi,et al.  Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[29]  D. Latchman,et al.  p53 Suppresses the Activation of the Bcl-2 Promoter by the Brn-3a POU Family Transcription Factor* , 1999, The Journal of Biological Chemistry.

[30]  Y. Tsujimoto,et al.  Bcl-2 Prevents Caspase-independent Cell Death* , 1998, The Journal of Biological Chemistry.

[31]  R. Gaynor,et al.  The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β , 1998, Nature.

[32]  J. Wallace,et al.  Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma. , 1998, Life sciences.

[33]  C. Borner,et al.  Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2* , 1998, The Journal of Biological Chemistry.

[34]  K. Kinzler,et al.  Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[35]  R. Gaynor,et al.  The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. , 1998, Nature.

[36]  T. Billiar,et al.  Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms* , 1997, The Journal of Biological Chemistry.

[37]  Stephen N. Jones,et al.  Regulation of p53 stability by Mdm2 , 1997, Nature.

[38]  M. Oren,et al.  Mdm2 promotes the rapid degradation of p53 , 1997, Nature.

[39]  A. M. Meijne,et al.  The role of integrins and integrin activation in liver metastasis. , 1994, Invasion & metastasis.

[40]  T. Decker,et al.  A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. , 1988, Journal of immunological methods.

[41]  T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.