Performance of the T2Candida Panel for the Diagnosis of Intra-abdominal Candidiasis

Abstract Performance of T2Candida for detecting intra-abdominal candidiasis (IAC) was assessed in 48 high-risk patients. T2Candida sensitivity/specificity and positive/negative predictive values were 33%/93% and 71%/74%, respectively. IAC was present in 100% of cases with concordant positive T2Candida/1,3-beta-d-glucan and absent in 90% of concordant negative results. Combination T2Candida/1,3-beta-d-glucan may help guide treatment decisions.

[1]  J. Schierbeck,et al.  Diagnostic Performance of T2Candida Among ICU Patients With Risk Factors for Invasive Candidiasis , 2019, Open forum infectious diseases.

[2]  A. Litvintseva,et al.  Evaluation of a new T2 Magnetic Resonance assay for rapid detection of emergent fungal pathogen Candida auris on clinical skin swab samples , 2018, Mycoses.

[3]  A. Caliendo,et al.  Detecting Infections Rapidly and Easily for Candidemia Trial, Part 2 (DIRECT2): A Prospective, Multicenter Study of the T2Candida Panel , 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[4]  C. Clancy,et al.  Diagnosing Invasive Candidiasis , 2018, Journal of Clinical Microbiology.

[5]  Alejandro Rodríguez,et al.  Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions , 2016, Critical Care.

[6]  S. Park,et al.  Intra-Abdominal Candidiasis: The Importance of Early Source Control and Antifungal Treatment , 2016, PloS one.

[7]  Donna M Wolk,et al.  T2MR and T2Candida: novel technology for the rapid diagnosis of candidemia and invasive candidiasis. , 2016, Future microbiology.

[8]  M. Antonelli,et al.  A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality , 2015, Intensive Care Medicine.

[9]  K. Garey,et al.  T2 magnetic resonance assay for the rapid diagnosis of candidemia in whole blood: a clinical trial. , 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[10]  P. Hauser,et al.  β-glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis. , 2013, American journal of respiratory and critical care medicine.

[11]  C. Castro,et al.  Value of β-d-glucan and Candida albicans germ tube antibody for discriminating between Candida colonization and invasive candidiasis in patients with severe abdominal conditions , 2012, Intensive Care Medicine.

[12]  C. Clancy,et al.  Performance of Candida real-time polymerase chain reaction, β-D-glucan assay, and blood cultures in the diagnosis of invasive candidiasis. , 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[13]  Jordi Rello,et al.  International study of the prevalence and outcomes of infection in intensive care units. , 2009, JAMA.

[14]  J. Kirby,et al.  Optimal use of Myco/F lytic and standard BACTEC blood culture bottles for detection of yeast and mycobacteria. , 2009, Archives of pathology & laboratory medicine.

[15]  Jay Steingrub,et al.  International study of the prevalence and outcomes of infection in intensive care units , 2009 .