Real-time full-field photoacoustic imaging using an ultrasonic camera.

A photoacoustic imaging system that incorporates a commercial ultrasonic camera for real-time imaging of two-dimensional (2-D) projection planes in tissue at video rate (30 Hz) is presented. The system uses a Q-switched frequency-doubled Nd:YAG pulsed laser for photoacoustic generation. The ultrasonic camera consists of a 2-D 12 x 12 mm CCD chip with 120 x 120 piezoelectric sensing elements used for detecting the photoacoustic pressure distribution radiated from the target. An ultrasonic lens system is placed in front of the chip to collect the incoming photoacoustic waves, providing the ability for focusing and imaging at different depths. Compared with other existing photoacoustic imaging techniques, the camera-based system is attractive because it is relatively inexpensive and compact, and it can be tailored for real-time clinical imaging applications. Experimental results detailing the real-time photoacoustic imaging of rubber strings and buried absorbing targets in chicken breast tissue are presented, and the spatial resolution of the system is quantified.

[1]  Massoud Motamedi,et al.  Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility study. , 2002, Applied optics.

[2]  Lihong V. Wang,et al.  Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer. , 2007, Journal of biomedical optics.

[3]  Da Xing,et al.  Fast full-view photoacoustic imaging by combined scanning with a linear transducer array. , 2007, Optics express.

[4]  Xu Xiao Photoacoustic imaging in biomedicine , 2008 .

[5]  Martin Frenz,et al.  Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo , 2005, IEEE Transactions on Medical Imaging.

[6]  Sridhar Krishnaswamy,et al.  INTEGRATION OF DIFFERENT SCANNING MODALITIES FOR REAL‐TIME DUAL‐CHANNEL ULTRASONIC INSPECTION OF AIRCRAFT STRUCTURES , 2008 .

[7]  Lihong V. Wang,et al.  Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging , 2006, Nature Biotechnology.

[8]  Lihong V. Wang,et al.  In vivo volumetric imaging of subcutaneous microvasculature by photoacoustic microscopy. , 2006, Optics express.

[9]  Risto A. Myllylae,et al.  Photoacoustic determination of glucose concentration in whole blood by a near-infrared laser diode , 2001, SPIE BiOS.

[10]  Lihong V. Wang Ultrasound-Mediated Biophotonic Imaging: A Review of Acousto-Optical Tomography and Photo-Acoustic Tomography , 2004, Disease markers.

[11]  Ronald I. Siphanto,et al.  Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis. , 2005, Optics express.

[12]  Neeta Parmar,et al.  An investigation of the use of transmission ultrasound to measure acoustic attenuation changes in thermal therapy , 2006, Medical and Biological Engineering and Computing.

[13]  Lihong V. Wang,et al.  In vivo dark-field reflection-mode photoacoustic microscopy. , 2005, Optics letters.

[14]  Ketan Mehta,et al.  128-channel laser optoacoustic imaging system (LOIS-128) for breast cancer diagnostics , 2006, SPIE BiOS.

[15]  Lihong V. Wang,et al.  Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries. , 2008, Optics letters.

[16]  Liang Song,et al.  Realtime photoacoustic microscopy in vivo with a 30-MHz ultrasound array transducer. , 2008, Optics express.

[17]  D. Prough,et al.  Continuous, noninvasive monitoring of total hemoglobin concentration by an optoacoustic technique. , 2004, Applied optics.

[18]  W. R. Davis,et al.  Real-time Ultrasonic Imaging Using CCD Camera Techniques , 2003 .