Norovirus Causes Pediatric Encephalopathy and Status Epilepticus: A Case Report and Review of the Literature

Abstract Norovirus is a common cause of acute gastroenteritis outbreaks worldwide. The disease can present with varying degrees of neurologic impairment from benign convulsions to rare cases of severe encephalopathy. In this article, we described a case report of a North American infant who presented with norovirus gastroenteritis, status epilepticus, severe encephalopathy, and abnormal but reversible diffusion restriction changes on magnetic resonance imaging of brain.

[1]  H. Kurahashi,et al.  A nationwide survey of norovirus-associated encephalitis/encephalopathy in Japan , 2019, Brain and Development.

[2]  Go-Shine Huang,et al.  Clinical Characteristics and Risk Factors for Seizures Associated With Norovirus Gastroenteritis in Childhood , 2017, Journal of child neurology.

[3]  B. Pinsky,et al.  Norovirus , 2015, Clinical Microbiology Reviews.

[4]  J. Takanashi,et al.  Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes , 2012, Brain and Development.

[5]  S. Sartori,et al.  Norovirus Gastroenteritis and Seizures: An Atypical Case with Neuroradiological Abnormalities , 2011, Neuropediatrics.

[6]  C. Chan,et al.  Norovirus as cause of benign convulsion associated with gastro‐enteritis , 2011, Journal of paediatrics and child health.

[7]  M. Uchino,et al.  An adult norovirus-related encephalitis/encephalopathy with mild clinical manifestation , 2010, BMJ Case Reports.

[8]  G. Dettori,et al.  Norovirus RNA in the blood of a child with gastroenteritis and convulsions--A case report. , 2010, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[9]  A. Okumura,et al.  Norovirus encephalopathy in a previously healthy child. , 2010, The Pediatric infectious disease journal.

[10]  C. Chiu,et al.  Norovirus infection as a cause of diarrhea-associated benign infantile seizures. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[11]  T. Matsuishi,et al.  Benign infantile convulsions associated with mild gastroenteritis: A retrospective study of 39 cases including virological tests and efficacy of anticonvulsants , 2007, Brain and Development.

[12]  S. Ito,et al.  Norovirus-associated encephalopathy. , 2006, The Pediatric infectious disease journal.

[13]  S. Fujimoto,et al.  Diffusion MRI abnormalities after prolonged febrile seizures with encephalopathy , 2006, Neurology.

[14]  Kazuyoshi Watanabe,et al.  Clinical features of benign convulsions with mild gastroenteritis , 2002, Brain and Development.