Idiopathic hypertrophic subaortic stenosis in the elderly.

Abstract Thirty-two per cent (14 of 44) of patients with idiopathic hypertrophic subaortic stenosis catheterized at the Massachusetts General Hospital were over the age of 60; in only five (36 per cent) of these patients was the diagnosis considered before catheterization. Comparison of these (median age, 65) with younger patients (median age, 39) revealed striking similarity in symptomatology, physical findings and routine laboratory data. However, three of the older patients (21 per cent) exhibited diastolic blowing murmurs (p less than 0.01), and two (14 per cent) had aortic-valve calcification on x-ray study (p less than 0.05); both were absent in younger patients. All older patients had resting left ventricular outflow-tract gradients (53 ± 9 mm [mean ± S.E.M.], of mercury) whereas 23 per cent of the younger patients had absent resting gradients (32 ± 5 mm [mean ± S.E.M.] of mercury) (p less than 0.05). Thus, a substantial number of patients with idiopathic hypertrophic subaortic stenosis are elderly...

[1]  J. Fabricius,et al.  Subvalvular aortic stenosis of muscular type. , 2009, Acta medica Scandinavica.

[2]  C. Oakley,et al.  Mechanism of mitral regurgitation in hypertrophic obstructive cardiomyopathy* , 1970, British heart journal.

[3]  W. Roberts,et al.  Muscular subaortic stenosis. Clinical and pathologic observations in an elderly patient. , 1968, The American journal of cardiology.

[4]  R. Peter,et al.  Subaortic stenosis simulating coronary disease. Report of 2 patients presenting problems in differential diagnosis. , 1968, Archives of internal medicine.

[5]  E. Braunwald,et al.  Idiopathic Hypertrophic Subaortic Stenosis: Clinical Analysis of 126 Patients with Emphasis on the Natural History , 1968, Circulation.

[6]  A. L. Simon,et al.  Angiographic Anatomy of the Left Ventricle and Mitral Valve in Idiopathic Hypertrophic Subaortic Stenosis , 1967, Circulation.

[7]  R. Dinsmore,et al.  Mitral regurgitation in idiopathic hypertrophic subaortic stenosis. , 1966, The New England journal of medicine.

[8]  C. Sanders,et al.  Idiopathic hypertrophic subaortic stenosis in two elderly siblings. , 1966, The New England journal of medicine.

[9]  A. D. Wolfe.  The A wave of the apex cardiogram in idiopathic hypertrophic subaortic stenosis. , 1966, British heart journal.

[10]  D. Littmann,et al.  ELECTROCARDIOGRAPHIC CHANGES IN HYPERTROPHIC SUBAORTIC STENOSIS WHICH SIMULATE MYOCARDIAL INFARCTION. , 1963, American heart journal.

[11]  A. L. Brown,et al.  The Clinical, Hemodynamic, and Pathologic Diagnosis of Muscular Subvalvular Aortic Stenosis , 1961, Circulation.

[12]  D. L. Fisher,et al.  Familial Muscular Subaortic Stenosis: An Unrecognized Form of "Idiopathic Heart Disease," with Clinical and Autopsy Observations , 1960, Circulation.

[13]  L. E. Lamb.  Electrocardiography and vectorcardiography : instrumentation, fundamentals, and clinical applications , 1965 .

[14]  Norman Brachfeld,et al.  FUNCTIONAL SUBAORTIC STENOSIS , 1961 .

[15]  R GORLIN,et al.  Hydraulic formula for calculation of the area of the stenotic mitral valve, other cardiac valves, and central circulatory shunts. I. , 1951, American heart journal.