Management of patients with severe sepsis, treated by drotrecogin alfa (activated).

[1]  J. Takamatsu,et al.  A Comparative Double-Blind Randomized Trial of Activated Protein C and Unfractionated Heparin in the Treatment of Disseminated Intravascular Coagulation , 2002, International journal of hematology.

[2]  F B Taylor,et al.  Towards Definition, Clinical and Laboratory Criteria, and a Scoring System for Disseminated Intravascular Coagulation , 2001, Thrombosis and Haemostasis.

[3]  C. Esmon,et al.  Dysfunction of endothelial protein C activation in severe meningococcal sepsis. , 2001, The New England journal of medicine.

[4]  W. Aird.  Vascular bed-specific hemostasis: Role of endothelium in sepsis pathogenesis , 2001, Critical care medicine.

[5]  L. Gelbert,et al.  Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis* , 2001, The Journal of Biological Chemistry.

[6]  J Ean,et al.  Efficacy and safety of recombinant human activated protein C for severe sepsis. , 2001, The New England journal of medicine.

[7]  José A Fernández,et al.  Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications , 2000, Critical care medicine.

[8]  T. van der Poll,et al.  Disseminated Intravascular Coagulation , 1999, Thrombosis and Haemostasis.

[9]  B. Alving,et al.  Women with thrombophilia: assessing the risks for thrombosis with oral contraceptives or hormone replacement therapy. , 1998, Seminars in thrombosis and hemostasis.

[10]  J. Corrigan.  Treatment dilemma in childhood idiopathic thrombocytopenic purpura , 1997, The Lancet.

[11]  R. Bertina,et al.  Activated Protein C Increases Fibrin Clot Lysis by Neutralization of Plasminogen Activator Inhibitor No Evidence for a Cofactor Role of Protein S , 1988, Thrombosis and Haemostasis.

[12]  V. V. van Hinsbergh,et al.  The Interaction of Activated Protein C and Thrombin with the Plasminogen Activator Inhibitor Released from Human Endothelial Cells , 1987, Thrombosis and Haemostasis.

[13]  A. Chang,et al.  Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. , 1987, The Journal of clinical investigation.

[14]  D. Feinstein.  Diagnosis and management of disseminated intravascular coagulation: the role of heparin therapy , 1982 .

[15]  C. Esmon,et al.  Generation of fibrinolytic activity by infusion of activated protein C into dogs. , 1981, The Journal of clinical investigation.

[16]  E. Davie,et al.  Preparation and properties of bovine factor VIII (antihemophilic factor). , 1980, Biochemistry.

[17]  C. Esmon,et al.  The inhibition of blood coagulation by activated Protein C through the selective inactivation of activated Factor V. , 1979, Biochimica et biophysica acta.

[18]  A. Sharp.  Diagnosis and management of disseminated intravascular coagulation. , 1977, British medical bulletin.