Proteomics and protein-protein interactions : biology, chemistry, bionformatics, and drug design

Introduction: Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, and Drug Design.- Yeast Two-Hybrid Protein-Protein Interaction Networks.- The Use of Mass Spectrometry in Studying Protein-Protein Interaction.- Molecular Recognition in the Immune System.- Computational Methods for Predicting Protein-Protein Interactions.- Protein-Protein Docking Methods.- Thermochemistry of Binary and Ternary Protein Interactions Measured by Titration Calorimetry: Complex Formation of CD4, HIV gp120, and Anti-gp120.- Protein-Protein Recognition in Phosphotyrosine-Mediated Intracellular Signaling.- Competitive Binding of Proline-Rich Sequences by SH3, WW, and Other Functionally Related Protein Domains.- The Structure and Molecular Interactions of the Bromodomain.- SMART Drug Design: Novel Phosphopeptide and ATP Mimetic-Based Small Molecule Inhibitors of the Oncogenic Protein Kinase pp60src (Src).- Disrupting Protein-Protein Interaction: Therapeutic Tools Against Brain Damage.- A Thermodynamic Guide to Affinity Optimization of Drug Candidates.