Drug Delivery to the Brain: Recent Advances and Unmet Challenges
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Arti Vashist | Adriana Yndart Arias | Sukanya Bhunia | Nagesh Kolishetti | Deborah Brooks | Madhavan Nair
[1] E. G. Varlamova,et al. Cerium Oxide Nanoparticles Protect Cortical Astrocytes from Oxygen–Glucose Deprivation through Activation of the Ca2+ Signaling System , 2023, International journal of molecular sciences.
[2] M. Nair,et al. Machine learning assisted-nanomedicine using magnetic nanoparticles for central nervous system diseases , 2023, Nanoscale advances.
[3] M. Nair,et al. Recent Advances in Nanotherapeutics for Neurological Disorders , 2023, ACS applied bio materials.
[4] M. Nair,et al. Multi-functional auto-fluorescent nanogels for theranostics , 2023, Journal of NeuroVirology.
[5] E. G. Varlamova,et al. Mesenchymal stromal cell-derived extracellular vesicles afford neuroprotection by modulating PI3K/AKT pathway and calcium oscillations , 2022, International journal of biological sciences.
[6] Manish K Jaiswal,et al. 2D Covalent Organic Framework Direct Osteogenic Differentiation of Stem Cells , 2022, Advanced healthcare materials.
[7] Liang Han. Modulation of the Blood–Brain Barrier for Drug Delivery to Brain , 2021, Pharmaceutics.
[8] M. Nair,et al. Recent advances, status, and opportunities of magneto-electric nanocarriers for biomedical applications. , 2021, Molecular aspects of medicine.
[9] Min Suk Shim,et al. Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy , 2021, Applied Sciences.
[10] E. G. Varlamova,et al. Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles , 2021, International journal of molecular sciences.
[11] M. Nair,et al. Brain-Accumulating Nanoparticles for Assisting Astrocytes to Reduce Human Immunodeficiency Virus and Drug Abuse-Induced Neuroinflammation and Oxidative Stress. , 2021, ACS nano.
[12] X. Qian,et al. Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications , 2021, International journal of nanomedicine.
[13] B. Brodin,et al. Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods , 2021, Micromachines.
[14] J. Frank,et al. Blood–brain barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses , 2021, Proceedings of the National Academy of Sciences.
[15] A. Iyer,et al. Transferrin: Biology and Use in Receptor-Targeted Nanotherapy of Gliomas , 2021, ACS omega.
[16] G. Terstappen,et al. Strategies for delivering therapeutics across the blood–brain barrier , 2021, Nature Reviews Drug Discovery.
[17] M. Tremblay,et al. Brain Ultrastructure: Putting the Pieces Together , 2021, Frontiers in Cell and Developmental Biology.
[18] A. Jemal,et al. Cancer Statistics, 2021 , 2021, CA: a cancer journal for clinicians.
[19] Junyong Wu,et al. From blood to brain: blood cell-based biomimetic drug delivery systems , 2021, Drug delivery.
[20] D. Yavagal,et al. Nanotechnology in the diagnosis and treatment of stroke. , 2020, Drug discovery today.
[21] K. Hynynen,et al. Applications of focused ultrasound in the brain: from thermoablation to drug delivery , 2020, Nature Reviews Neurology.
[22] N. Lipsman,et al. Blood-Brain Barrier Disruption in Neuro-Oncology: Strategies, Failures, and Challenges to Overcome , 2020, Frontiers in Oncology.
[23] G. Tiram,et al. Targeting Glioblastoma: Advances in Drug Delivery and Novel Therapeutic Approaches , 2020 .
[24] S. Dhar,et al. Metabolic Modulation of the Tumor Microenvironment Leads to Multiple Checkpoint Inhibition and Immune Cell Infiltration. , 2020, ACS nano.
[25] M. Versluis,et al. Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography. , 2020, Journal of controlled release : official journal of the Controlled Release Society.
[26] S. Auriola,et al. L-Type amino acid transporter 1 as a target for drug delivery , 2020, Pharmaceutical Research.
[27] R. Banerjee,et al. Combating glioblastoma by co-delivering small molecule inhibitor of STAT3 and STAT3siRNA with α5β1 integrin receptor selective liposomes. , 2020, Molecular pharmaceutics.
[28] G. Martinez-Zayas,et al. Brain Targeted Gold Liposomes Improve RNAi Delivery for Glioblastoma , 2020, International journal of nanomedicine.
[29] Ziying Liu,et al. Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human , 2020, Fluids and Barriers of the CNS.
[30] Yang Song,et al. Overcoming blood-brain barrier transport: Advances in nanoparticle-based drug delivery strategies. , 2020, Materials today.
[31] M. Vannier,et al. Imaging of intranasal drug delivery to the brain. , 2020, American journal of nuclear medicine and molecular imaging.
[32] N. Ibrahim,et al. ANG1005, a Brain-Penetrating Peptide–Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases , 2020, Clinical Cancer Research.
[33] H. T. Aiyelabegan,et al. Toxicity assessment of superparamagnetic iron oxide nanoparticles in different tissues , 2020, Artificial cells, nanomedicine, and biotechnology.
[34] Hye Rim Cho,et al. Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors , 2019, Nature Communications.
[35] P. Pattany,et al. MRI-Guided, Noninvasive Delivery of Magneto-Electric Drug Nanocarriers to the Brain in a Nonhuman Primate. , 2019, ACS applied bio materials.
[36] Quanyin Hu,et al. Sequentially Site-Specific Delivery of Thrombolytics and Neuroprotectant for Enhanced Treatment of Ischemic Stroke. , 2019, ACS nano.
[37] José Luis Molinuevo,et al. Tip of the Iceberg: Assessing the Global Socioeconomic Costs of Alzheimer’s Disease and Related Dementias and Strategic Implications for Stakeholders , 2019, Journal of Alzheimer's disease : JAD.
[38] A. Schätzlein,et al. Nose-to-Brain Delivery , 2019, The Journal of Pharmacology and Experimental Therapeutics.
[39] M. Nair,et al. Magnetically guided non-invasive CRISPR-Cas9/gRNA delivery across blood-brain barrier to eradicate latent HIV-1 infection , 2019, Scientific Reports.
[40] Thomas Lars Andresen,et al. Modulating the antibody density changes the uptake and transport at the blood‐brain barrier of both transferrin receptor‐targeted gold nanoparticles and liposomal cargo , 2019, Journal of controlled release : official journal of the Controlled Release Society.
[41] R. Samulski,et al. Adeno-Associated Virus (AAV) Versus Immune Response , 2019, Viruses.
[42] S. Peters,et al. Brain metastases , 2019, Nature Reviews Disease Primers.
[43] B. Marples,et al. Nanotechnology-mediated crossing of two impermeable membranes to modulate the stars of the neurovascular unit for neuroprotection , 2018, Proceedings of the National Academy of Sciences.
[44] K. Tachibana,et al. Iduronate-2-Sulfatase with Anti-human Transferrin Receptor Antibody for Neuropathic Mucopolysaccharidosis II: A Phase 1/2 Trial , 2018, Molecular therapy : the journal of the American Society of Gene Therapy.
[45] B. Marples,et al. A designer bow-tie combination therapeutic platform: An approach to resistant cancer treatment by simultaneous delivery of cytotoxic and anti-inflammatory agents and radiation. , 2018, Biomaterials.
[46] J. Bulte,et al. Real-Time MRI Guidance for Reproducible Hyperosmolar Opening of the Blood-Brain Barrier in Mice , 2018, Front. Neurol..
[47] F. Erdő,et al. Evaluation of intranasal delivery route of drug administration for brain targeting , 2018, Brain Research Bulletin.
[48] Ling Zhang,et al. Dopamine‐loaded blood exosomes targeted to brain for better treatment of Parkinson's disease , 2018, Journal of controlled release : official journal of the Controlled Release Society.
[49] K. Hynynen,et al. Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer’s disease , 2018, Scientific Reports.
[50] B. Ravina,et al. Gene therapy for neurological disorders: progress and prospects , 2018, Nature Reviews Drug Discovery.
[51] K. Yagi,et al. Angubindin‐1 opens the blood–brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system , 2018, Journal of controlled release : official journal of the Controlled Release Society.
[52] Mathias Schmidt,et al. Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 trial , 2018, Orphanet Journal of Rare Diseases.
[53] K. Hynynen,et al. Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery , 2018, Journal of controlled release : official journal of the Controlled Release Society.
[54] Jeffrey Wyckoff,et al. Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles , 2018, Nature Communications.
[55] A. Chaudhuri,et al. A lipid-based cell penetrating nano-assembly for RNAi-mediated anti-angiogenic cancer therapy. , 2018, Chemical communications.
[56] Berislav V. Zlokovic,et al. Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders , 2018, Nature Reviews Neurology.
[57] Roger M. Leblanc,et al. Crossing the blood‐brain barrier with nanoparticles , 2018, Journal of controlled release : official journal of the Controlled Release Society.
[58] A. Chaudhuri,et al. Large Amino Acid Transporter 1 Selective Liposomes of l-DOPA Functionalized Amphiphile for Combating Glioblastoma. , 2017, Molecular pharmaceutics.
[59] E. Ruppin,et al. Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome , 2017, eLife.
[60] Alexander V Kabanov,et al. Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain. , 2017, Biomaterials.
[61] Kullervo Hynynen,et al. Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose , 2017, Theranostics.
[62] K. Yagi,et al. Angubindin‐1, a novel paracellular absorption enhancer acting at the tricellular tight junction , 2017, Journal of controlled release : official journal of the Controlled Release Society.
[63] N. Nishiyama,et al. cRGD peptide‐installed epirubicin‐loaded polymeric micelles for effective targeted therapy against brain tumors , 2017, Journal of controlled release : official journal of the Controlled Release Society.
[64] Q. Ping,et al. Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence. , 2017, Nature nanotechnology.
[65] David R. Myers,et al. Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions , 2017, Nature Communications.
[66] Miles A. Miller,et al. Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts , 2017, Science Translational Medicine.
[67] C. Damianou,et al. Amyloid β Plaque Reduction With Antibodies Crossing the Blood‐Brain Barrier, Which Was Opened in 3 Sessions of Focused Ultrasound in a Rabbit Model , 2017, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.
[68] Cao Xie,et al. Multifunctional targeted liposomal drug delivery for efficient glioblastoma treatment , 2017, Oncotarget.
[69] Chih-Kuang Yeh,et al. Characterization of Different Microbubbles in Assisting Focused Ultrasound-Induced Blood-Brain Barrier Opening , 2017, Scientific Reports.
[70] N. Pala,et al. Investigation of ac-magnetic field stimulated nanoelectroporation of magneto-electric nano-drug-carrier inside CNS cells , 2017, Scientific Reports.
[71] K. Hynynen,et al. Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome , 2017, Scientific Reports.
[72] G. Huberfeld,et al. Safe long-term repeated disruption of the blood-brain barrier using an implantable ultrasound device: a multiparametric study in a primate model. , 2017, Journal of neurosurgery.
[73] A. Kaushik,et al. Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood–Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro , 2017, Journal of Neuroimmune Pharmacology.
[74] Jennie W. Taylor,et al. A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma , 2017, Cancer Chemotherapy and Pharmacology.
[75] S. Saha,et al. Combating Established Mouse Glioblastoma through Nicotinylated‐Liposomes‐Mediated Targeted Chemotherapy in Combination with Dendritic‐Cell‐Based Genetic Immunization , 2017, Advanced biosystems.
[76] V. Radha,et al. CDC20siRNA and paclitaxel co-loaded nanometric liposomes of a nipecotic acid-derived cationic amphiphile inhibit xenografted neuroblastoma. , 2017, Nanoscale.
[77] Neekita Jikaria,et al. Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation , 2016, Proceedings of the National Academy of Sciences.
[78] P. Kantoff,et al. Cancer nanomedicine: progress, challenges and opportunities , 2016, Nature Reviews Cancer.
[79] Y. Li,et al. Delivery of a peptide-drug conjugate targeting the blood brain barrier improved the efficacy of paclitaxel against glioma , 2016, Oncotarget.
[80] N. McDannold,et al. Growth inhibition in a brain metastasis model by antibody delivery using focused ultrasound-mediated blood-brain barrier disruption. , 2016, Journal of controlled release : official journal of the Controlled Release Society.
[81] E. Konofagou,et al. Longitudinal Motor and Behavioral Assessment of Blood-Brain Barrier Opening with Transcranial Focused Ultrasound. , 2016, Ultrasound in medicine & biology.
[82] A. Kaushik,et al. Getting into the brain: Potential of nanotechnology in the management of NeuroAIDS. , 2016, Advanced drug delivery reviews.
[83] J. Kuo,et al. Focused Ultrasound Enhances Central Nervous System Delivery of Bevacizumab for Malignant Glioma Treatment. , 2016, Radiology.
[84] R. Mahley. Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism. , 2016, Arteriosclerosis, thrombosis, and vascular biology.
[85] M. Nair,et al. Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers , 2016, Scientific Reports.
[86] Sourav R. Choudhury,et al. Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector. , 2016, Molecular therapy : the journal of the American Society of Gene Therapy.
[87] K. Gadkar,et al. Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain. , 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[88] P. Walczak,et al. Predicting and optimizing the territory of blood–brain barrier opening by superselective intra-arterial cerebral infusion under dynamic susceptibility contrast MRI guidance , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[89] M. Nair,et al. Microglia-derived HIV Nef+ exosome impairment of the blood–brain barrier is treatable by nanomedicine-based delivery of Nef peptides , 2015, Journal of NeuroVirology.
[90] M. Nair,et al. Therapeutical Neurotargeting via Magnetic Nanocarrier: Implications to Opiate-Induced Neuropathogenesis and NeuroAIDS. , 2015, Journal of biomedical nanotechnology.
[91] S. Dhar,et al. Evaluation of nanoparticle delivered cisplatin in beagles. , 2015, Nanoscale.
[92] N. André,et al. Phase I study of non-pegylated liposomal doxorubicin in children with recurrent/refractory high-grade glioma , 2015, Cancer Chemotherapy and Pharmacology.
[93] S. Dhar,et al. Targeted nanoparticles in mitochondrial medicine. , 2015, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.
[94] M. Griswold,et al. Treatment of Invasive Brain Tumors Using a Chain-like Nanoparticle. , 2015, Cancer research.
[95] T. Wurdinger,et al. Overcoming the blood-brain tumor barrier for effective glioblastoma treatment. , 2015, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[96] B. Weber,et al. The Astrocyte: Powerhouse and Recycling Center. , 2015, Cold Spring Harbor perspectives in biology.
[97] M. Nair,et al. Sustained-release nanoART formulation for the treatment of neuroAIDS , 2015, International journal of nanomedicine.
[98] Vivaldo Moura-Neto,et al. Gliomas and the vascular fragility of the blood brain barrier , 2014, Front. Cell. Neurosci..
[99] D. Matias,et al. The impact of microglial activation on blood-brain barrier in brain diseases , 2014, Front. Cell. Neurosci..
[100] R. Alkins,et al. Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival. , 2014, Neuro-oncology.
[101] A. Califano,et al. Convection-enhanced delivery of etoposide is effective against murine proneural glioblastoma. , 2014, Neuro-oncology.
[102] V. Chekhonin,et al. Targeted Delivery of Cisplatin by Сonnexin 43 Vector Nanogels to the Focus of Experimental Glioma C6 , 2014, Bulletin of Experimental Biology and Medicine.
[103] A. Brand,et al. Gap Junction Proteins in the Blood-Brain Barrier Control Nutrient-Dependent Reactivation of Drosophila Neural Stem Cells , 2014, Developmental cell.
[104] Harald Sontheimer,et al. Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells , 2014, Nature Communications.
[105] X. Jian,et al. A case report of acute severe paraquat poisoning and long-term follow-up , 2014, Experimental and therapeutic medicine.
[106] P. Henrich-Noack,et al. Surfactants, not size or zeta-potential influence blood-brain barrier passage of polymeric nanoparticles. , 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[107] E. Konofagou,et al. The Size of Blood–Brain Barrier Opening Induced by Focused Ultrasound is Dictated by the Acoustic Pressure , 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[108] B. Imhof,et al. Tight junction dynamics: the role of junctional adhesion molecules (JAMs) , 2014, Cell and Tissue Research.
[109] W. Wick,et al. Progression-free survival as a surrogate endpoint for overall survival in glioblastoma: a literature-based meta-analysis from 91 trials , 2013, Neuro-oncology.
[110] Chen Jiang,et al. T7 peptide-functionalized nanoparticles utilizing RNA interference for glioma dual targeting. , 2013, International journal of pharmaceutics.
[111] S. Dhar,et al. Nanocarriers for tracking and treating diseases. , 2013, Current medicinal chemistry.
[112] S. Saxena,et al. Targeted Brain Derived Neurotropic Factors (BDNF) Delivery across the Blood-Brain Barrier for Neuro-Protection Using Magnetic Nano Carriers: An In-Vitro Study , 2013, PloS one.
[113] Jeongmin Hong,et al. Externally controlled on-demand release of anti-HIV drug using magneto-electric nanoparticles as carriers , 2013, Nature Communications.
[114] Jijin Gu,et al. Integrin-facilitated transcytosis for enhanced penetration of advanced gliomas by poly(trimethylene carbonate)-based nanoparticles encapsulating paclitaxel. , 2013, Biomaterials.
[115] K. Hynynen,et al. Focused ultrasound delivers targeted immune cells to metastatic brain tumors. , 2013, Cancer research.
[116] Sophia Lee,et al. Impact of Natalizumab on Ambulatory Improvement in Secondary Progressive and Disabled Relapsing-Remitting Multiple Sclerosis , 2013, PloS one.
[117] P. Couraud,et al. Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation , 2012, Fluids and Barriers of the CNS.
[118] Xiaoling Fang,et al. Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles. , 2012, Biomaterials.
[119] W. Pardridge,et al. Drug Transport across the Blood–Brain Barrier , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[120] A. Lamprecht,et al. Drug delivery strategies for the treatment of malignant gliomas. , 2012, International journal of pharmaceutics.
[121] K. Yue,et al. Magneto-Electric Nano-Particles for Non-Invasive Brain Stimulation , 2012, PloS one.
[122] X. Jing,et al. Fluorescence-labeled immunomicelles: preparation, in vivo biodistribution, and ability to cross the blood-brain barrier. , 2012, Macromolecular bioscience.
[123] W. Lu. Adsorptive-mediated brain delivery systems. , 2012, Current pharmaceutical biotechnology.
[124] K. Hynynen,et al. Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound. , 2012, Human gene therapy.
[125] Sumit Arora,et al. Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers , 2012, International journal of nanomedicine.
[126] Chen Jiang,et al. Gene and doxorubicin co-delivery system for targeting therapy of glioma. , 2012, Biomaterials.
[127] Christoph W. Blau,et al. Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury , 2012, Nature Communications.
[128] A. Brenner,et al. Safety, Pharmacokinetics, and Activity of GRN1005, a Novel Conjugate of Angiopep-2, a Peptide Facilitating Brain Penetration, and Paclitaxel, in Patients with Advanced Solid Tumors , 2011, Molecular Cancer Therapeutics.
[129] Kullervo Hynynen,et al. Targeted Delivery of Neural Stem Cells to the Brain Using MRI-Guided Focused Ultrasound to Disrupt the Blood-Brain Barrier , 2011, PloS one.
[130] M. Ott,et al. The ABC of the blood-brain barrier - regulation of drug efflux pumps. , 2011, Current pharmaceutical design.
[131] W. Luk,et al. Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target , 2011, Science Translational Medicine.
[132] A. Rezai,et al. AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial , 2011, The Lancet Neurology.
[133] Takashi Suzuki,et al. Quantitative targeted absolute proteomics of human blood–brain barrier transporters and receptors , 2011, Journal of neurochemistry.
[134] T. Schwartz,et al. Safety and maximum tolerated dose of superselective intraarterial cerebral infusion of bevacizumab after osmotic blood-brain barrier disruption for recurrent malignant glioma. Clinical article. , 2011, Journal of neurosurgery.
[135] K. Hynynen,et al. Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats , 2010, BMC neurology.
[136] D. Attwell,et al. Glial and neuronal control of brain blood flow , 2010, Nature.
[137] G. Fan,et al. Indirubin-3'-monoxime rescues spatial memory deficits and attenuates β-amyloid-associated neuropathology in a mouse model of Alzheimer's disease , 2010, Neurobiology of Disease.
[138] G. Miller. Is pharma running out of brainy ideas? , 2010, Science.
[139] Rajiv Chopra,et al. Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease , 2010, PloS one.
[140] Paul R. Carney,et al. Regional convection-enhanced delivery of gadolinium-labeled albumin in the rat hippocampus in vivo , 2010, Journal of Neuroscience Methods.
[141] D. Yin,et al. Optimized cannula design and placement for convection-enhanced delivery in rat striatum , 2010, Journal of Neuroscience Methods.
[142] M. Nair,et al. Magnetic nanoformulation of azidothymidine 5’-triphosphate for targeted delivery across the blood–brain barrier , 2010, International journal of nanomedicine.
[143] R. Langer,et al. Emerging nanotechnology approaches for HIV/AIDS treatment and prevention. , 2010, Nanomedicine.
[144] Yunhui Liu,et al. Bradykinin increases the permeability of the blood-tumor barrier by the caveolae-mediated transcellular pathway , 2010, Journal of Neuro-Oncology.
[145] Gareth J.S. Jenkins,et al. Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION) , 2010, Nano reviews.
[146] J. Benoit,et al. Convection-enhanced delivery of nanocarriers for the treatment of brain tumors. , 2009, Biomaterials.
[147] N. Philpott,et al. Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors , 2009, Gene Therapy.
[148] B. Lorenz,et al. Detection of Intact rAAV Particles up to 6 Years After Successful Gene Transfer in the Retina of Dogs and Primates. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.
[149] Christoph W. Blau,et al. RNAi‐mediated reversible opening of the blood‐brain barrier , 2008, The journal of gene medicine.
[150] K. Hynynen,et al. Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption. , 2008, Ultrasound in medicine & biology.
[151] S. Vandenberg,et al. Safety of real-time convection-enhanced delivery of liposomes to primate brain: A long-term retrospective , 2008, Experimental Neurology.
[152] David Eidelberg,et al. Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial , 2007, The Lancet.
[153] N. Jong,et al. Ultrasound microbubble induced endothelial cell permeability. , 2006, Journal of controlled release : official journal of the Controlled Release Society.
[154] R. Samulski,et al. Adeno-associated virus serotypes: vector toolkit for human gene therapy. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[155] Manabu Kinoshita,et al. Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[156] J. Haorah,et al. Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions , 2006, Journal of Neuroimmune Pharmacology.
[157] K. Hynynen,et al. Targeted disruption of the blood–brain barrier with focused ultrasound: association with cavitation activity , 2006, Physics in medicine and biology.
[158] Barry W Wessels,et al. Safety and Feasibility of Convection-enhanced Delivery of Cotara for the Treatment of Malignant Glioma: Initial Experience in 51 Patients , 2005, Neurosurgery.
[159] Susan M. Chang,et al. Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma. , 2005, Journal of neurosurgery.
[160] Ferenc A. Jolesz,et al. Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications , 2005, NeuroImage.
[161] Willem Boogerd,et al. Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours? , 2004, Cancer treatment reviews.
[162] K. Hynynen,et al. Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. , 2004, Ultrasound in medicine & biology.
[163] Michael Weaver,et al. Transferrin Receptor Ligand-Targeted Toxin Conjugate (Tf-CRM107) for Therapy of Malignant Gliomas , 2003, Journal of Neuro-Oncology.
[164] A. Levitzki,et al. Inhibition of glioma growth by tumor-specific activation of double-stranded RNA–dependent protein kinase PKR , 2002, Nature Biotechnology.
[165] Marco van Vulpen,et al. Changes in blood-brain barrier permeability induced by radiotherapy: implications for timing of chemotherapy? (Review). , 2002, Oncology reports.
[166] Peter Ramge,et al. Apolipoprotein-mediated Transport of Nanoparticle-bound Drugs Across the Blood-Brain Barrier , 2002, Journal of drug targeting.
[167] K. Hynynen,et al. Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. , 2001, Radiology.
[168] S E Maier,et al. Monitoring response to convection-enhanced taxol delivery in brain tumor patients using diffusion-weighted magnetic resonance imaging. , 2001, Cancer research.
[169] B. Mokri. The Monro–Kellie hypothesis , 2001, Neurology.
[170] Henry Brem,et al. Drug delivery to tumors of the central nervous system , 2001, Current neurology and neuroscience reports.
[171] D. Begley,et al. Polysorbate‐80 coating enhances uptake of polybutylcyanoacrylate (PBCA)‐nanoparticles by human and bovine primary brain capillary endothelial cells , 2000, The European journal of neuroscience.
[172] H. Engelhard,et al. The role of interstitial BCNU chemotherapy in the treatment of malignant glioma. , 2000, Surgical neurology.
[173] E. Blakely,et al. Human glioblastoma cell lines: levels of low-density lipoprotein receptor and low-density lipoprotein receptor-related protein. , 2000, Cancer research.
[174] D. Trono,et al. Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery , 1998, Journal of Virology.
[175] F. Bloom,et al. Central analgesic actions of loperamide following transient permeation of the blood brain barrier with Cereport™ (RMP-7) 1 Published on the World Wide Web on 30 June 1998. 1 , 1998, Brain Research.
[176] T. Cloughesy,et al. Intracarotid infusion of RMP-7, a bradykinin analog, and transport of gallium-68 ethylenediamine tetraacetic acid into human gliomas. , 1997, Journal of neurosurgery.
[177] P. Fan,et al. Quantitative analysis of the packaging capacity of recombinant adeno-associated virus. , 1996, Human gene therapy.
[178] R. Bartus,et al. Pathway across blood-brain barrier opened by the bradykinin agonist, RMP-7 , 1995, Brain Research.
[179] M. Tableman,et al. Toxicity and efficacy of carboplatin and etoposide in conjunction with disruption of the blood-brain tumor barrier in the treatment of intracranial neoplasms. , 1995, Neurosurgery.
[180] J. Kreuter,et al. Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles) , 1995, Brain Research.
[181] K. Black,et al. Bradykinin Selectively Opens Blood-Tumor Barrier in Experimental Brain Tumors , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[182] P F Morrison,et al. Convection-enhanced delivery of macromolecules in the brain. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[183] E. Oldfield,et al. Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice. , 1994, Journal of neurosurgery.
[184] R. Fine,et al. Receptor-mediated endocytosis of transferrin at the blood-brain barrier. , 1993, Journal of cell science.
[185] R. Braziel,et al. Primary CNS lymphoma treated with osmotic blood-brain barrier disruption: prolonged survival and preservation of cognitive function. , 1991, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[186] R. E. Pitas,et al. Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. , 1987, The Journal of biological chemistry.
[187] S. Rapoport,et al. Osmotic opening of tight junctions in cerebral endothelium , 1973, The Journal of comparative neurology.
[188] S. Rapoport,et al. Testing of a hypothesis for osmotic opening of the blood-brain barrier. , 1972, The American journal of physiology.
[189] A. Jovicić,et al. Blood-Brain Barrier , 2019, Neuromethods.
[190] S. Kügler,et al. MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain. , 2019, Methods in molecular biology.
[191] M. Aghi,et al. Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies. , 2017, Journal of neurosurgery.
[192] R. Daneman,et al. The blood-brain barrier. , 2015, Cold Spring Harbor perspectives in biology.
[193] Huile Gao,et al. Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles. , 2015, Biomaterials.
[194] R. Weichselbaum,et al. Convection-enhanced delivery and in vivo imaging of polymeric nanoparticles for the treatment of malignant glioma. , 2014, Nanomedicine : nanotechnology, biology, and medicine.
[195] K. Rapti,et al. Neutralizing antibodies against AAV serotypes 1, 2, 6, and 9 in sera of commonly used animal models. , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.
[196] K. Foust,et al. Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes , 2009, Nature Biotechnology.
[197] F A Jolesz,et al. Non-invasive opening of BBB by focused ultrasound. , 2003, Acta neurochirurgica. Supplement.