Combretastatin A-4 disodium phosphate: a vascular targeting agent that improves that improves the anti-tumor effects of hyperthermia, radiation, and mild thermoradiotherapy.

[1]  A. Hart,et al.  Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial , 2000, The Lancet.

[2]  B. Schem,et al.  The new tubulin-inhibitor combretastatin A-4 enhances thermal damage in the BT4An rat glioma. , 2000, International journal of radiation oncology, biology, physics.

[3]  G. Rosner,et al.  The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy. , 1999, International journal of radiation oncology, biology, physics.

[4]  D. Chaplin,et al.  Tumour vasculature as a target for cancer therapy. , 1999, British journal of cancer.

[5]  B Vojnovic,et al.  Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues. , 1999, Cancer research.

[6]  J. Overgaard,et al.  The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors. , 1998, International journal of radiation oncology, biology, physics.

[7]  A. Rojiani,et al.  Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy. , 1998, International journal of radiation oncology, biology, physics.

[8]  W. Wilson,et al.  Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs. , 1998, British Journal of Cancer.

[9]  G. Rosner,et al.  Hyperthermic treatment of malignant diseases: current status and a view toward the future. , 1997, Seminars in oncology.

[10]  G. Tozer,et al.  Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. , 1997, Cancer research.

[11]  J. Overgaard,et al.  The in vivo interaction between flavone acetic acid and hyperthermia. , 1996, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[12]  D. Chaplin,et al.  Antivascular approaches to solid tumour therapy: evaluation of tubulin binding agents. , 1996, The British journal of cancer. Supplement.

[13]  D Machin,et al.  Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. , 1996, International journal of radiation oncology, biology, physics.

[14]  D. Chaplin,et al.  Anti—vascular approaches to solid tumour therapy: Evaluation of vinblastine and flavone acetic acid , 1995, International journal of cancer.

[15]  M. Horsman,et al.  Ischaemia induced cell death in tumors: importance of temperature and pH. , 1994, International journal of radiation oncology, biology, physics.

[16]  N. Bleehen,et al.  A study of the mechanism of hydralazine enhancement of thermal damage in the KHT tumour. , 1991, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[17]  J. Overgaard,et al.  Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinoma in vivo. , 1989, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[18]  T. Colby,et al.  Cell kill and tumor control after heat treatment with and without vascular occlusion in RIF-1 tumors. , 1986, Radiation research.

[19]  J. Overgaard Simultaneous and sequential hyperthermia and radiation treatment of an experimental tumor and its surrounding normal tissue in vivo. , 1980, International journal of radiation oncology, biology, physics.

[20]  O. S. Nielsen,et al.  THE ROLE OF TISSUE ENVIRONMENTAL FACTORS ON THE KINETICS AND MORPHOLOGY OF TUMOR CELLS EXPOSED TO HYPERTHERMIA * , 1980, Annals of the New York Academy of Sciences.

[21]  T. Powles,et al.  Non-steroidal anti-inflammatory drugs and cytotoxics. , 1979, Cancer treatment reviews.

[22]  S. B. Field,et al.  Hyperthermia in the treatment of cancer. , 1979, Cancer treatment reviews.

[23]  L. Gerweck,et al.  Response of cells to hyperthermia under acute and chronic hypoxic conditions. , 1979, Cancer research.

[24]  J. Denekamp,et al.  The effect of vascular occlusion on the thermal sensitization of a mouse tumour. , 1978, The British journal of radiology.

[25]  J. Overgaard,et al.  The influence of hypoxia and acidity on the hyperthermic response of malignant cells in vitro. , 1977, Radiology.

[26]  G. Crile The effects of heat and radiation on cancers implanted on the feet of mice. , 1963, Cancer research.

[27]  J. Overgaard,et al.  Comparative effects of combretastatin A-4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on blood perfusion in a murine tumour and normal tissues. , 2001, International journal of radiation biology.

[28]  J. Overgaard,et al.  Improving local tumor control by combining vascular targeting drugs, mild hyperthermia and radiation. , 2001, Acta oncologica.

[29]  D. Chaplin,et al.  Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate. , 1999, Anticancer research.

[30]  J. Oleson Eugene Robertson Special Lecture. Hyperthermia from the clinic to the laboratory: a hypothesis. , 1995, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[31]  M. Horsman,et al.  The influence of tumour temperature on ischemia-induced cell death: potential implications for the evaluation of vascular mediated therapies. , 1994, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[32]  L. Thomsen,et al.  Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism. , 1991, European journal of cancer.

[33]  P. Okunieff,et al.  Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors. , 1990, Cancer research.