Chalcones considered as the precursor of flavonoids and isoflavonoids abundantly found in plants, and have also been shown to display a diverse array of pharmacological activities. This review is complementary to earlier reviews and covers more recent report of antimicrobial activity of chalcones as well as its important role as an intermediate for the synthesis of different synthetic molecules. The enone linkage presents in basic structure play crucial role for the activity of chalcone and chalcone derivatives. The members of the chalcone and flavonoid family have attracted a great deal of interest due to it has showed diffent activity as antibacterial, antifungal, anti-inflammatory, antihyperglycemic anti HIV and anticancer pharmacological activity. Recently a molecule of chalcone has been reported as a novel class of HIV-1 integrase inhibitors. The purpose of this review is to focus on some important pharmacological activity of the chalcone and its derivatives.
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