Early phase process scale-up challenges for fungal and filamentous bacterial cultures

[1]  M. Moo-young,et al.  Bioprocessing strategies for improving hen egg-white lysozyme (HEWL) production by recombinant Aspergillusniger HEWL WT-13–16 , 2002, Applied Microbiology and Biotechnology.

[2]  B. Junker,et al.  Use of frozen bagged seed inoculum for secondary metabolite and bioconversion processes at the pilot scale. , 2002, Biotechnology and bioengineering.

[3]  D. Barrett.  From natural products to clinically useful antifungals. , 2002, Biochimica et biophysica acta.

[4]  J. Bae,et al.  Changes in morphology of Paecilomyces japonica and their effect on broth rheology during production of exo-biopolymers , 2001, Applied Microbiology and Biotechnology.

[5]  D. Schmatz,et al.  Species-specific inhibition of fungal protein synthesis by sordarin: identification of a sordarin-specificity region in eukaryotic elongation factor 2. , 2001, Microbiology.

[6]  B. Junker,et al.  Retrofit of CD-6 (smith) impeller in fermentation vessels , 2000, Applied biochemistry and biotechnology.

[7]  A. Nienow,et al.  Dependence of mycelial morphology on impeller type and agitation intensity , 2000, Biotechnology and bioengineering.

[8]  B. Kristiansen,et al.  Hyphal vacuolation and fragmentation in batch and fed-batch culture of Aspergillus niger and its relation to citric acid production , 1999 .

[9]  L. Pera,et al.  Influence of calcium on fungal growth and citric acid production during fermentation of a sugarcane molasses-based medium by a strain of Aspergillus niger , 1999 .

[10]  U. Rinas,et al.  Fungal morphology in submerged cultures and its relation to glucose oxidase excretion by recombinant Aspergillus niger , 1999, Applied biochemistry and biotechnology.

[11]  L. Harvey,et al.  Heterologous protein secretion and fungal morphology in chemostat cultures of a recombinant Aspergillus niger (B1-D) , 1999 .

[12]  T. Anke,et al.  Influence of morphology and rheology on the production characteristics of the basidiomycete Cyathus striatus. , 1998, Biotechnology and bioengineering.

[13]  K. Luyben,et al.  Influence of fermentation conditions and scale on the submerged fermentation of Aspergillus awamori , 1998 .

[14]  K. Luyben,et al.  Effects of dissolved oxygen tension and mechanical forces on fungal morphology in submerged fermentation. , 1998, Biotechnology and bioengineering.

[15]  B. McNeil,et al.  Effect of carbon dioxide on morphology and product synthesis in chemostat cultures of Aspergillus niger A60 , 1997 .

[16]  M. Bushell,et al.  The effect of morphology and oxygen uptake on penicillin production by Aspergillus nidulans in submerged culture , 1997 .

[17]  K. Luyben,et al.  Effect of agitation intensities on fungal morphology of submerged fermentation. , 1997, Biotechnology and bioengineering.

[18]  Teh-liang Chen,et al.  Effect of thickening agents on the penicillin fermentation , 1997 .

[19]  R. P. Chambers,et al.  Characterization of a Ca-alginate-immobilized Trametes versicolor bioreactor for decolorization and AOX reduction of paper mill effluents , 1997 .

[20]  D. Mackenzie,et al.  Heterologous protein secretion by Aspergillus niger growing in submerged culture as dispersed or aggregated mycelia , 1995, Applied Microbiology and Biotechnology.

[21]  B. Kristiansen,et al.  Morphology and citric acid production of Aspergillus niger PM 1 , 1994, Biotechnology Letters.

[22]  C. Thomas,et al.  Inoculum effects on fungal morphology: Shake flasks vs agitated bioreactors , 1994 .

[23]  E. Olsvik,et al.  Correlation of Aspergillus niger broth rheological properties with biomass concentration and the shape of mycelial aggregates , 1993, Biotechnology and bioengineering.

[24]  P N Royce,et al.  Effect of changes in the pH and carbon dioxide evolution rate on the measured respiratory quotient of fermentations , 1992, Biotechnology and bioengineering.

[25]  C. Thomas,et al.  Mycelial morphology: The effect of spore inoculum level , 1992, Biotechnology Letters.

[26]  R. Monaghan,et al.  L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. I. The producing organism and its fermentation. , 1992, The Journal of antibiotics.

[27]  Y. Sasson,et al.  Nikkomycin production in pellets of Streptomyces tendae. , 1992, The Journal of applied bacteriology.

[28]  T. Roukas.  Influence of impeller speed on citric acid production and selected enzyme activities of the TCA cycle , 1991, Journal of Industrial Microbiology.

[29]  M. T. Belmar-Beiny,et al.  Morphology and clavulanic acid production of Streptomyces clavuligerus: Effect of stirrer speed in batch fermentations , 1991, Biotechnology and bioengineering.

[30]  T. Koloini,et al.  Submerged citric acid fermentation: rheological properties ofAspergillus niger broth in a stirred tank reactor , 1991, Applied Microbiology and Biotechnology.

[31]  S. Braun,et al.  Mycelial morphology and metabolite production , 1991 .

[32]  S E Vecht-Lifshitz,et al.  Pellet formation and cellular aggregation in Streptomyces tendae , 1990, Biotechnology and bioengineering.

[33]  P. Lawton,et al.  Actinomycete morphology in shaken culture , 1989 .

[34]  J. Riba,et al.  Morphology and growth of Aspergillus niger ATCC 26036 cultivated at several shear rates. , 1988, Biotechnology and bioengineering.

[35]  R. Gómez,et al.  Pellet growth and citric acid yield of Aspergillus niger 110 , 1988 .

[36]  R. Orthofer,et al.  Accumulation and partial re-consumption of polyols during citric acid fermentation by Aspergillus niger , 1987, Applied Microbiology and Biotechnology.

[37]  Chester S. Ho,et al.  Effect of dissolved carbon dioxide on penicillin fermentations: Mycelial growth and penicillin production , 1986, Biotechnology and bioengineering.

[38]  C. Kubicek,et al.  Aconitase and citric acid fermentation by Aspergillus niger , 1985, Applied and environmental microbiology.

[39]  Henry J. Fastert,et al.  Fermentation Exhaust Gas Analysis Using Mass Spectrometry , 1985, Bio/Technology.

[40]  B. Matusiak,et al.  The effect of acetate on the production of citric acid by Aspergillus niger in submerged fermentation , 1984, Applied Microbiology and Biotechnology.

[41]  A. Trinci.  Effect of Junlon on morphology of Aspergillus niger and its use in making turbidity measurements of fungal growth , 1983 .

[42]  K. Schügerl,et al.  The use of molds in pellet form , 1983 .

[43]  C. Kubicek,et al.  Kinetics of biomass formation and citric acid production by Aspergillus niger on pilot plant scale , 1981 .

[44]  J. C. van Suijdam,et al.  Influence of engineering variables upon the morphology of filamentous molds , 1981 .

[45]  N. Kossen,et al.  An inoculum technique for the production of fungal pellets , 1980, European journal of applied microbiology and biotechnology.

[46]  C. T. Calam,et al.  Variations in inocula and their influence on the productivity of antibiotic fermentations , 1980, Biotechnology Letters.

[47]  C. Kubicek,et al.  Regulation of citric acid production by oxygen: Effect of dissolved oxygen tension on adenylate levels and respiration in Aspergillus niger , 1980, European journal of applied microbiology and biotechnology.

[48]  C. Kubicek,et al.  The role of the tricarboxylic acid cycle in citric acid accumulation by Aspergillus niger , 1978, European journal of applied microbiology and biotechnology.

[49]  C. Kubicek,et al.  Influence of manganese on enzyme synthesis and citric acid accumulation inAspergillus niger , 1977, European journal of applied microbiology and biotechnology.

[50]  N. Kossen,et al.  The growth of molds in the form of pellets–a literature review , 1977 .

[51]  M. Moo-young,et al.  Effects of polymer additives on fermentation parameters in a culture of A. niger , 1973 .

[52]  A. Trinci.  Kinetics of the growth of mycelial pellets of Aspergillus nidulans , 1970, Archiv für Mikrobiologie.

[53]  J. Smith,et al.  Filamentous growth of Aspergillus niger in submerged shake culture , 1969 .

[54]  S. Pirt,et al.  Metal-complexing agents as metal buffers in media for the growth of Aspergillus niger. , 1965, Journal of general microbiology.

[55]  Koichi Yamada,et al.  Effect of Mycelial Forms on Citric Acid Fermentation in Submerged Mold Culture , 1965 .

[56]  D. S. Clark.  Submerged citric acid fermentation of ferrocyanide-treated beet molasses: morphology of pellets of Aspergillus niger. , 1962, Canadian journal of microbiology.

[57]  P. Mill,et al.  The pectic enzymes of Aspergillus niger. 1. The production of active mixtures of pectic enzymes. , 1961, The Biochemical journal.

[58]  S. Pirt,et al.  Continuous-Flow Culture of the Filamentous Mould Penicillium Chrysogenum and the Control of its Morphology , 1959, Nature.

[59]  R. T. Darby,et al.  Inorganic Nutrition of Myrothecium Verrucaria , 1954 .

[60]  V. F. Pfeifer,et al.  SODIUM GLUCONATE PRODUCTION. FERMENTATION WITH ASPERGILLUS NIGER , 1952 .

[61]  Maria Papagianni,et al.  Fungal morphology and metabolite production in submerged mycelial processes. , 2004, Biotechnology advances.

[62]  J Schmitt,et al.  Design and Installation of a Next Generation Pilot Scale Fermentation System , 2003, Biotechnology progress.

[63]  Mark R. Marten,et al.  Effects of Increased Impeller Power in a Production‐Scale Aspergillusoryzae Fermentation , 2002, Biotechnology progress.

[64]  E. Park,et al.  Dependence of Apparent Viscosity on Mycelial Morphology of Streptomyces fradiae Culture in Various Nitrogen Sources , 2000, Biotechnology progress.

[65]  J. Hunik,et al.  Influence of Morphology on Product Formation in Aspergillusawamori during Submerged Fermentations , 1998, Biotechnology progress.

[66]  E. Park,et al.  Improvement of tylosin production from Streptomyces fradiae culture by decreasing the apparent viscosity in an air-lift bioreactor , 1998 .

[67]  Yong Soo Park,et al.  Change of mycelial morphology in tylosin production by batch culture of Streptomyces fradiae under various shear conditions , 1997 .

[68]  Y. Yoo,et al.  Control of Intracellular Ammonium Level Using Specific Oxygen Uptake Rate for Overproduction of Citric Acid by Aspergillus niger , 1995 .

[69]  M. Fujita,et al.  Analysis of pellet formation of Aspergillus niger based on shear stress , 1994 .

[70]  K. Schügerl,et al.  Influence of the preculture conditions on the pellet size distribution of Penicillium chrysogenum cultivations , 1993 .

[71]  A. Whitaker.  Actinomycetes in submerged culture , 1992, Applied biochemistry and biotechnology.

[72]  G. N. Qazi,et al.  Pilot-scale citric acid production with Aspergillus niger under several conditions , 1990 .

[73]  A. Trinci,et al.  Effects of Junlon and Hostacerin on the Electrokinetic Properties of Spores of Aspergillus niger, Phanerochaete chrysosporium and Geotrichum candidum , 1988 .

[74]  G. N. Qazi,et al.  Production of citric acid by submerged fermentation. Effect of medium sterilisation at pilot-plant level: Production of citric acid by submerged fermentation , 1981 .