Synchronized beating of and electrotonic transmission between myocardial cells mediated by heterotypic strain cells in monolayer culture.

Abstract 1. 1. The strain cells, FL, HeLa-S3, XX-male, NIHT6L, 3T3, Vero, BSC-1, LLCMK2, CNQ-1, CNQT-2, 4NTH, SVT and HA-111, mediated synchronized beating of mouse embryonic myocardial cells in monolayer cultures. 2. 2. The strain cells, L and one type of NQ-19/clone no. 4, did not mediate the synchronized beating of myocardial cells. 3. 3. Rhythmical depolarization potentials were recorded from HeLa-S3 cells mediating the synchronized beating of myocardial cells.

[1]  L. Barr,et al.  Propagation of Action Potentials and the Structure of the Nexus in Cardiac Muscle , 1965, The Journal of general physiology.

[2]  M. Stoker.  A SIMPLE MARKER TECHNIQUE FOR CELLS IN CULTURE. , 1964, Experimental cell research.

[3]  Robert L. DeHaan,et al.  Regulation of spontaneous activity and growth of embryonic chick heart cells in tissue culture , 1967 .

[4]  N. Sperelakis,et al.  Prepotentials and unidirectional propagation in myocardium. , 1961, The American journal of physiology.

[5]  I. Harary,et al.  In vitro studies on single beating rat heart cells. I. Growth and organization. , 1963, Experimental cell research.

[6]  M. V. Bennett,et al.  Physiology and ultrastructure of electrotonic junctions. II. Spinal and medullary electromotor nuclei in mormyrid fish. , 1967, Journal of neurophysiology.

[7]  W. Loewenstein,et al.  STUDIES ON AN EPITHELIAL (GLAND) CELL JUNCTION. II. SURFACE STRUCTURE. , 1964 .

[8]  N. Sperelakis,et al.  Effect of Current on Transmembrane Potentials in Cultured Chick Heart Cells , 1964, The Journal of general physiology.

[9]  I HARARY,et al.  In vitro studies on single beating rat heart cells. II. Intercellular communication. , 1963, Experimental cell research.

[10]  A. Hodgkin,et al.  The diffusion of radiopotassium across intercalated disks of mammalian cardiac muscle , 1966, The Journal of physiology.

[11]  M. V. Bennett,et al.  Physiology and ultrastructure of electrotonic junctions. IV. Medullary electromotor nuclei in gymnotid fish. , 1967, Journal of neurophysiology.

[12]  M. V. Bennett,et al.  Physiology and ultrastructure of electrotonic junctions. 3. Giant electromotor neurons of Malapterurus electricus. , 1967, Journal of neurophysiology.

[13]  K. Goshima,et al.  Synchronized beating of embryonic mouse myocardial cells mediated by FL cells in monolayer culture. , 1969, Experimental cell research.

[14]  G E Mark,et al.  Pacemaker activity and mitosis in cultures of newborn rat heart ventricle cells. , 1966, Experimental cell research.

[15]  M. V. Bennett,et al.  Physiology and ultrastructure of electrotonic junctions. I. Supramedullary neurons. , 1967, Journal of neurophysiology.

[16]  Werner R. Loewenstein,et al.  STUDIES ON AN EPITHELIAL (GLAND) CELL JUNCTION I. Modifications of Surface Membrane Permeability , 1964 .