Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain.
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Matthew S. Johnson | C. Shieh | James B. Thomas | R. Atkinson | P. Honore | K. Marsh | M. Jarvis | C. Faltynek | M. Kort | R. Gregg | S. Joshi | Xufeng Zhang | G. Simler | M. Chapman | M. Krambis | Brett M. Antonio | M. Scanio | Lei Shi | I. Drizin | Dong Liu | Yi Liu | A. Knox | S. Werness | D. Krafte | B. Marron