Anatomy of Cluster Development in China: The case of health biotech clusters

Focussing on China’s health biotech clusters the study explores the anatomy of interaction in as well as between various clusters. While the literature has identified the existence of a dense network of durable interactions among firms and between firms and academia at a particular location as one of the most important prerequisites for well-performing clusters, we show that network ties extending beyond regional boundaries are equally valuable for the innovative capacity of China’s biotech firms. Analysing the demographic process of cluster emergence we show that there exist different types of biotech clusters in China, which are closely linked and exchange knowledge and technology amongst each other. It appears as if further analysis of these cross-cluster links may provide important insights of how learning and innovation works in China’s health biotech industry. Although China’s science parks and industrial bases may on an individual basis appear to be badly structured, the organization of China’s health biotech industry turns out to be substantially enhanced once these external linkages are taken into consideration.

[1]  F. Malerba,et al.  Technological Regimes and Firm Bebavior , 1993 .

[2]  J. Henderson,et al.  Efficiency of resource usage and city size , 1986 .

[3]  Maryann P. Feldman,et al.  The Genesis of Industrial Clusters , 2007 .

[4]  A world away from venture capital funds: biotechnology and finance in Shanghai , 2009 .

[5]  Xian-wen Hu,et al.  Biopharmaceuticals in China , 2006, Biotechnology journal.

[6]  A. Malmberg,et al.  Localized learning revisited , 2006 .

[7]  Elaine Romanelli,et al.  Anatomy of Cluster Development: Emergence and Convergence in the US Human Biotherapeutics, 1976-2003 , 2007 .

[8]  M. Storper The Limits to Globalization: Technology Districts and International Trade , 1992 .

[9]  Chad R. Miller,et al.  Alternate signs of life: The growth of biotechnology industries in Shanghai and Bangalore , 2011 .

[10]  R. Boschma Proximity and Innovation: A Critical Assessment , 2005 .

[11]  Tong Xin,et al.  An Innovative Region in China: Interaction Between Multinational Corporations and Local Firms in a High-Tech Cluster in Beijing , 2003 .

[12]  Salih Zeki Ozdemir,et al.  Vertical alliance networks: The case of university–biotechnology–pharmaceutical alliance chains , 2007 .

[13]  Johanna L. Francis,et al.  Creating a Cluster While Building a Firm: Entrepreneurs and the Formation of Industrial Clusters , 2005 .

[14]  Walter W. Powell,et al.  Accounting for Emergence and Novelty in Boston and Bay Area Biotechnology , 2007 .

[15]  Markus Taube,et al.  Regional specialization in China's biopharmaceutical industry , 2010 .

[16]  S. Breschi,et al.  Knowledge Spillovers And Local Innovation Systems: A Critical Survey , 2001 .

[17]  M. Aoki Corporations in Evolving Diversity: Cognition, Governance, and Institutions , 2010 .

[18]  F. Malerba,et al.  The Geography of Innovation and Economic Clustering: Some Introductory Notes , 2001 .

[19]  Franco Malerba,et al.  Knowledge, innovative activities and industrial evolution , 2000 .

[20]  Meric S. Gertler,et al.  Tacit knowledge and the economic geography of context, or The undefinable tacitness of being (there) , 2003 .

[21]  D. Teece Profiting from technological innovation: Implications for integration, collaboration, licensing and public policy , 1993 .

[22]  M. Porter Clusters and the new economics of competition. , 1998, Harvard business review.

[23]  James Wilsdon,et al.  China: the next science superpower? , 2007 .

[24]  L. Leydesdorff The triple helix: an evolutionary model of innovations , 2000 .

[25]  L. Yueh,et al.  Wage Reforms in China During the 1990s , 2004 .

[26]  Henry G. Grabowski,et al.  Innovation and Structural Change in Pharmaceuticals and Biotechnology , 1994 .

[27]  M. Feldman The New Economics Of Innovation, Spillovers And Agglomeration: Areview Of Empirical Studies , 1999 .

[28]  J. Dunning Location and the multinational enterprise: A neglected factor? , 1998 .

[29]  Yantai Chen,et al.  Development Trajectories in the Biotechnology Industry: China Versus Leading Countries , 2011 .

[30]  Richard P. Suttmeier,et al.  China's Innovation Challenge and the Remaking of the Chinese Academy of Sciences , 2006, Innovations: Technology, Governance, Globalization.

[31]  Cong Cao,et al.  Zhongguancun and China's High-Tech Parks in Transition: ““Growing Pains”” or ““Premature Senility””? , 2004 .

[32]  Paula E. Stephan,et al.  Company-Scientist Locational Links: The Case of Biotechnology , 1996 .

[33]  B. Lundvall,et al.  Forms of knowledge and modes of innovation , 2007 .

[34]  Paul A. David,et al.  The explicit economics of knowledge codification and tacitness , 2000 .

[35]  Aodheen O'Donnell,et al.  The network construct in entrepreneurship research: a review and critique , 2001 .

[36]  Davide Chiaroni,et al.  Forms of creation of industrial clusters in biotechnology , 2006 .

[37]  Dylan Sutherland,et al.  China's Science Parks: Production Bases or a Tool for Institutional Reform? , 2005 .

[38]  P. Krugman Geography and Trade , 1992 .

[39]  POLICY-INDUCED CLUSTERS THE GENESIS OF BIOTECHNOLOGY CLUSTERING ON THE EAST COAST OF CHINA , 2005 .

[40]  Daniel A. Levinthal,et al.  ABSORPTIVE CAPACITY: A NEW PERSPECTIVE ON LEARNING AND INNOVATION , 1990 .

[41]  Wei Zhang,et al.  Financing new ventures in China: System antecedents and institutionalization , 2005 .

[42]  J. Rayner,et al.  Cloning an industry: Strategy typologies of Shanghai biotechnology companies , 2008 .

[43]  Paul A. Gompers,et al.  The Venture Capital Revolution , 2001 .

[44]  Y. Wei Beyond the Sunan Model: Trajectory and Underlying Factors of Development in Kunshan, China , 2002 .

[45]  A. Malmberg,et al.  (How) Do (Firms in) Clusters Create Knowledge? , 2005 .

[46]  Zhang Lei,et al.  Roles, models and development trends of hi-tech industrial development zones in China , 2004, Int. J. Technol. Manag..

[47]  Luc Soete,et al.  Catching up in technology: entry barriers and windows of opportunity , 1988 .

[48]  Xielin Liu,et al.  Comparing innovation systems: a framework and application to China’s transitional context , 2001 .

[49]  Ke-jing Chen,et al.  HOW MUCH DOES HISTORY MATTER? AN ANALYSIS OF THE GEOGRAPHIC DISTRIBUTION OF VENTURE CAPITAL INVESTMENT IN THE U.S. BIOTECHNOLOGY INDUSTRY , 2009 .

[50]  Technology Policies in Generating Biotechnology Clusters: A Comparison of China and the US , 2008 .

[51]  R. Sternberg,et al.  Return migration in regional innovation systems) , 2005 .

[52]  G. Pisano Using Equity Participation to Support Exchange: Evidence from the Biotechnology Industry , 1989 .

[53]  A. Daar,et al.  Chinese health biotech and the billion-patient market , 2008, Nature Biotechnology.

[54]  Yehua Dennis Wei,et al.  Restructuring Industrial Districts, Scaling Up Regional Development: A Study of the Wenzhou Model, China , 2007 .

[55]  Keun Lee,et al.  Explaining the “University-run enterprises” in China: A theoretical framework for university–industry relationship in developing countries and its application to China☆ , 2006 .

[56]  O. Williamson Comparative Economic Organization: The Analysis of Discrete Structural Alternatives , 1994 .

[57]  U. Witt Novelty and the bounds of unknowledge in economics , 2009 .

[58]  Yu-Shan Su,et al.  Spontaneous vs. policy-driven: The origin and evolution of the biotechnology cluster , 2009 .

[59]  P. Cooke,et al.  Regional innovation systems: Institutional and organisational dimensions , 1997 .

[60]  Steven Casper,et al.  How do technology clusters emerge and become sustainable? Social network formation and inter-firm mobility within the San Diego biotechnology cluster , 2007 .

[61]  A. Markusen Sticky Places in Slippery Space: A Typology of Industrial Districts* , 1996 .

[62]  Adam Brandenburger,et al.  The Right Game: Use Game Theory to Shape Strategy , 2009 .

[63]  S. Klepper Employee Startups in High‐Tech Industries , 2001 .

[64]  David L. Deeds,et al.  Exploration and Exploitation Alliances in Biotechnology: A System of New Product Development , 2004 .