Initial management of epilepsy.

The diagnosis and management of patient with epilepsy is often undertaken by general practitioner, pediatrician, internist and geriatrician. Referral to a neurologist may be necessary if the diagnosis of epilepsy is unclear or if the patient does not respond to initial therapy with antiepileptic drugs. General practitioners may subsequently follow up the patients in order to implement the recommendations of the neurologist. To maximize the likelihood of treatment success, general practitioners should supplement anti epileptic therapy (AED) with patient education and referral for psychosocial and vocational support when needed.4

[1]  S. Shorvon,et al.  Results of treatment changes in patients with apparently drug‐resistant chronic epilepsy , 2007, Annals of neurology.

[2]  P. Kwan,et al.  Early identification of refractory epilepsy. , 2000, The New England journal of medicine.

[3]  First Seizure.  Randomized clinical trial on the efficacy of antiepileptic drugs in reducing the risk of relapse after a first unprovoked tonic‐clonic seizure , 1993, Neurology.

[4]  A. Marson,et al.  Lamotrigine versus carbamazepine monotherapy for epilepsy. , 2006, The Cochrane database of systematic reviews.

[5]  A. Marson,et al.  Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial , 2005, The Lancet.

[6]  S. Schachter.  Antiepileptic Drug Therapy: General Treatment Principles and Application for Special Patient Populations , 1999, Epilepsia.

[7]  M. Nei,et al.  Seizure-related injury and death , 2007, Current neurology and neuroscience reports.

[8]  P. Brocklehurst,et al.  Common antiepileptic drugs in pregnancy in women with epilepsy , 2007 .

[9]  H Feldman,et al.  Seizure control and mortality in epilepsy , 1999, Annals of neurology.

[10]  Easton Jd,et al.  Seizure Recurrence After a First, Unprovoked Seizure , 1986 .

[11]  Catrin Tudur Smith,et al.  Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. , 2001, The Cochrane database of systematic reviews.

[12]  A. Berg,et al.  Risk of recurrence after a first unprovoked seizure , 2008, Epilepsia.

[13]  A. Verma.  Prediction of risk of seizure recurrence after a single seizure and early epilepsy: further results from the MESS trial , 2008 .

[14]  M. Whitehead,et al.  Labor market participation following onset of seizures and early epilepsy: Findings from a UK cohort , 2009, Epilepsia.

[15]  N. Adab.  Therapeutic monitoring of antiepileptic drugs during pregnancy and in the postpartum period: is it useful? , 2006, CNS drugs.

[16]  W. Hauser,et al.  Likelihood of seizure remission in an adult population with refractory epilepsy , 2007, Annals of neurology.

[17]  Catrin Tudur Smith,et al.  Carbamazepine versus phenobarbitone monotherapy for epilepsy. , 2003, The Cochrane database of systematic reviews.

[18]  Matti Sillanpää,et al.  Mortality of Epilepsy in Developed Countries: A Review , 2005, Epilepsia.

[19]  G. Hammond-Tooke.  The management of epilepsy in adults. , 1993, The New Zealand medical journal.

[20]  M Sculpher,et al.  Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation. , 2005, Health technology assessment.

[21]  E. Faught,et al.  Monotherapy in adults and elderly persons , 2007, Neurology.

[22]  Josemir W Sander,et al.  Cause‐Specific Mortality in Epilepsy , 2005, Epilepsia.

[23]  E. Faught,et al.  Nonadherence to antiepileptic drugs and increased mortality , 2008, Neurology.

[24]  E. Beghi,et al.  Treatment of first tonic-clonic seizure does not improve the prognosis of epilepsy , 1997, Neurology.