A “humid electronic nose” for the detection of nerve agent mimics; a case of selective sensing of DCNP (a Tabun mimic)

Abstract A “humid electronic nose” device based on pulse voltammetry has been applied to detect nerve agent simulants in gas phase. The “humid electronic nose” consists in a polypropylene piece which contains an array of eight metallic electrodes (i.e., Ir, Rh, Pt, Au Ag, Co, Cu and Ni) divided into two sets of four working electrodes housed inside a homemade steel cylinder, and a salt bridge connection to a reference electrode. The electrochemical system is fitted to a nylon membrane damped with a background solution of sodium tetraborate 0.01 M by a second polypropylene piece. The PCA analysis demonstrated that the system is able to discern principal organophosphorous nerve agent mimics (DCP, DCNP and DFP) from organophosphorous derivatives and some other potential interferents. Besides, the PLS quantification analysis showed sound accuracy in the concentration prediction for DCNP in air, good linearity and a limit of detection (LOD) of some a few ppm.

[1]  R. Martínez‐Máñez,et al.  Discrimination of nerve gases mimics and other organophosphorous derivatives in gas phase using a colorimetric probe array. , 2012, Chemical communications.

[2]  Carles Cané,et al.  Chemical warfare agents simulants detection with an optimized SAW sensor array , 2011 .

[3]  D. Aguado,et al.  A voltammetric electronic tongue as tool for water quality monitoring in wastewater treatment plants. , 2012, Water research.

[4]  van Ra Rutger Santen,et al.  The role of adsorbates in the electrochemical oxidation of ammonia on noble and transition metal electrodes , 2001 .

[5]  T. Swager,et al.  Carbon nanotube/polythiophene chemiresistive sensors for chemical warfare agents. , 2008, Journal of the American Chemical Society.

[6]  M. Pardo,et al.  Metal Oxide Nanowire and Thin-Film-Based Gas Sensors for Chemical Warfare Simulants Detection , 2008, IEEE Sensors Journal.

[7]  T. Jacobsen,et al.  Membrane-covered oxygen electrodes , 1978 .

[8]  A P Watson,et al.  The sources, fate, and toxicity of chemical warfare agent degradation products. , 1999, Environmental health perspectives.

[9]  Roberto Paolesse,et al.  Electronic tongue based on an array of metallic potentiometric sensors. , 2006, Talanta.

[10]  Ramón Martínez-Máñez,et al.  Use of a Voltammetric Electronic Tongue for Detection and Classification of Nerve Agent Mimics , 2010 .

[11]  Heidi J. VanTreeck,et al.  Quantitative detection of a simulant of organophosphonate chemical warfare agents using liquid crystals , 2011 .

[12]  I. Alnashef,et al.  Superoxide Electrochemistry in an Ionic Liquid , 2002 .

[13]  Gerhard J Mohr,et al.  New chromogenic and fluorogenic reagents and sensors for neutral and ionic analytes based on covalent bond formation–a review of recent developments , 2006, Analytical and bioanalytical chemistry.

[14]  Eduard Llobet,et al.  A novel humid electronic nose combined with an electronic tongue for assessing deterioration of wine , 2011 .

[15]  Gregory P. Harmer,et al.  Detection of chemical warfare agents using nanostructured metal oxide sensors , 2005 .

[16]  H. Hill,et al.  Conventional analytical methods for chemical warfare agents , 2002 .

[17]  Rafael Masot,et al.  A method of pulse array design for voltammetric electronic tongues , 2012 .

[18]  R. Martínez‐Máñez,et al.  Prediction of NaCl, nitrate and nitrite contents in minced meat by using a voltammetric electronic tongue and an impedimetric sensor , 2010 .

[19]  Yadong Jiang,et al.  Synthesis and evaluation of a new polysiloxane as SAW sensor coatings for DMMP detection , 2008 .

[20]  N. Gabouze,et al.  Electrochemical gas sensors based on polypyrrole-porous silicon , 2013 .

[21]  M. Soriaga,et al.  The Influence of Chemisorbed Organic Monolayers on Electrode Surface Oxidation , 1991 .

[22]  R. Martínez‐Máñez,et al.  Chromogenic detection of nerve agent mimics. , 2008, Chemical communications.

[23]  K. Persaud,et al.  Analysis of discrimination mechanisms in the mammalian olfactory system using a model nose , 1982, Nature.

[24]  Carles Cané,et al.  Love-wave sensor array to detect, discriminate and classify chemical warfare agent simulants , 2012 .

[25]  I. Lundström,et al.  Monitoring of freshness of milk by an electronic tongue on the basis of voltammetry , 1998 .

[26]  F. Winquist,et al.  Discrimination of tea by means of a voltammetric electronic tongue and different applied waveforms , 2001 .

[27]  J. Wadhawan,et al.  Voltammetry of oxygen in the room-temperature ionic liquids 1-ethyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imide and hexyltriethylammonium bis((trifluoromethyl)sulfonyl)imide: One-electron reduction to form superoxide. Steady-state and transient behavior in the same cyclic voltammogram re , 2003 .

[28]  Santiago Royo,et al.  Chromogenic and fluorogenic reagents for chemical warfare nerve agents' detection. , 2007, Chemical communications.

[29]  Mamta Khaneja,et al.  Development of handheld SAW vapor sensors for explosives and CW agents , 2009 .

[30]  Alan J Russell,et al.  Biomaterials for mediation of chemical and biological warfare agents. , 2003, Annual review of biomedical engineering.

[31]  M. Iwaki,et al.  Electrochemical gas sensor using a novel gas permeable electrode modified by ion implantation , 2007 .

[32]  N. Lawrence,et al.  Determination of ammonia based on the electro-oxidation of hydroquinone in dimethylformamide or in the room temperature ionic liquid, 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide. , 2004, Talanta.

[33]  N. Bârsan,et al.  Electronic nose: current status and future trends. , 2008, Chemical reviews.

[34]  José M. Barat,et al.  Accurate concentration determination of anions nitrate, nitrite and chloride in minced meat using a voltammetric electronic tongue , 2010 .

[35]  Lisa Tabassi,et al.  Making Treaties Work: The Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on their Destruction (Chemical Weapons Convention) , 2007 .

[36]  Joseph Wang.  Carbon‐Nanotube Based Electrochemical Biosensors: A Review , 2005 .

[37]  W. J. Albery,et al.  A mebrane electrode for the determination of CO2 and O2 , 1982 .

[38]  J. Kanwisher,et al.  Electrode System for Measuring Dissolved Oxygen , 1959 .

[39]  R. Chaudhary,et al.  Solvation, transduction and independent component analysis for pattern recognition in SAW electronic nose , 2006 .

[40]  Joseph R. Stetter,et al.  The properties and applications of amperometric gas sensors , 1992 .

[41]  Satu M. Somani,et al.  Chemical warfare agents , 1992 .

[42]  Tai Hyun Park,et al.  Recent advances in electronic and bioelectronic noses and their biomedical applications. , 2011, Enzyme and microbial technology.

[43]  Kevin J. Johnson,et al.  A novel chemical detector using cermet sensors and pattern recognition methods for toxic industrial chemicals , 2006 .

[44]  Eduardo Garcia-Breijo,et al.  A humid electronic nose based on pulse voltammetry: A proof-of-concept design , 2013 .

[45]  I. Karube,et al.  Evaluation of chemical oxygen demand (COD) based on coulometric determination of electrochemical oxygen demand (EOD) using a surface oxidized copper electrode , 1999 .

[46]  Richard G Compton,et al.  Use of room temperature ionic liquids in gas sensor design. , 2004, Analytical chemistry.

[47]  I. Alnashef,et al.  Electrochemical Generation of Superoxide in Room-Temperature Ionic Liquids , 2001 .

[48]  A. D. Wilson,et al.  Review of electronic-nose technologies and algorithms to detect hazardous chemicals in the environment , 2012 .

[49]  Félix Sancenón,et al.  Chromogenic detection of nerve agent mimics by mass transport control at the surface of bifunctionalized silica nanoparticles. , 2010, Angewandte Chemie.