ANALYSIS AND DESIGN OF INDUCTIVE BIOSENSORS FOR MAGNETIC IMMUNO ASSAY

In this paper an inductive integrated sensor for biomedical applications is investigated through analytical models and numerical simulations such to obtain an optimized device design. This biosensor addressed here is based on the use of magnetic particles that suitably coated act as markers of the bio-molecule to be detected. The sensing principle of the device is related to the magnetic field thickening determined by the presence of magnetic particles in the active device area. An accurate finite element numerical simulation is therefore necessary to optimize the sensor performances; simulations have been performed by representing the magnetic particles with an equivalent volume having the same magnetic properties. The simulations have allowed analysing the influence of the different device parameters on the sensor response. An optimized design procedure has been therefore sketched and the results are reported in this paper.

[1]  M. Zolgharni,et al.  An Inductance-based Sensor for DNA Hybridization Detection , 2007, 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems.

[2]  D. Kriz,et al.  Magnetic Transducers in Biosensors and Bioassays , 1999 .

[3]  S. Baglio,et al.  Integrated inductive sensors for the detection of magnetic microparticles , 2005, IEEE Sensors Journal.

[4]  A. Romano-Rodriguez,et al.  Microcoils for biosensors fabricated by focused ion beam (FIB) , 2005, Conference on Electron Devices, 2005 Spanish.

[5]  D. Kriz,et al.  Advancements toward magneto immunoassays. , 1998, Biosensors & bioelectronics.

[6]  Gil U. Lee,et al.  A high-sensitivity micromachined biosensor , 1997, Proc. IEEE.

[7]  R. Colton,et al.  The BARC biosensor applied to the detection of biological warfare agents. , 2000, Biosensors & bioelectronics.

[8]  Jaume Esteve,et al.  Si technology based microinductive devices for biodetection applications , 2006 .