Surface-enhanced Raman analysis of sulfa drugs on colloidal silver dispersion.

Surface-enhanced Raman spectrometry (SERS) of three sulfa drugs (sulfadiazine, sulfamerazine, and sulfamethazine) is reported. Silver colloidal dispersions prepared by simple borohydride reduction of silver nitrate are used as substrates. The capability of SERS for spectral fingerprinting of analytes with close structural properties using easily prepared substrates and relatively simple instrumentation is illustrated. By careful attention to the timing in the measurement, quantitative information can be obtained from silver colloids. Linearity was achieved up to 100 ng mL-1. Limits of detection range in the low nanograms per milliliter level.

[1]  A. C. Bratton,et al.  A NEW COUPLING COMPONENT FOR SULFANILAMIDE DETERMINATION , 1939 .

[2]  R. Rauh,et al.  Feasibility studies for the detection of organic surface and subsurface water contaminants by surface-enhanced Raman spectroscopy on silver electrodes. , 1987, Analytical chemistry.

[3]  J. Creighton,et al.  Plasma resonance — enhanced raman scattering by absorbates on gold colloids: The effects of aggregation , 1982 .

[4]  J. Winefordner,et al.  Studies of sample preparation for surface-enhanced raman spectrometry on silver hydrosols , 1987 .

[5]  J. M. Worlock,et al.  Surface picosecond raman gain spectroscopy of a cyanide monolayer on silver , 1979 .

[6]  A. Blades.  The role of thermal decomposition in the degradation of organic compounds in the flame ionization detector , 1984 .

[7]  K. Johnson,et al.  High-pressure liquid chromatographic determination of sulfamethazine residue in bovine tissue. , 1975, Journal of pharmaceutical sciences.

[8]  A. Nicholson.  Decomposition reactions in the flame ionization detector , 1982 .

[9]  J. Winefordner,et al.  Evaluation and optimization of experimental conditions for surface-enhanced Raman detection of analytes in flow injection analysis , 1988 .

[10]  William G. Fateley,et al.  Characteristic Raman frequencies of organic compounds , 1974 .

[11]  A. Blades.  The Flame Ionization Detector , 1973 .

[12]  Surface-enhanced Raman spectrometry on a silver-coated filter paper substrate , 1988 .

[13]  A. Blades.  Ion formation in hydrocarbon flames , 1976 .

[14]  J. Winefordner,et al.  Mixture analysis and quantitative determination of nitrogen-containing organic molecules by surface-enhanced Raman spectrometry. , 1989, Analytical chemistry.

[15]  T. Cool,et al.  Direct observations of chemi-ionization in hydrocarbon flames enhanced by laser excited CH*(A 2 Δ) and CH*(B2Σ−) , 1984 .

[16]  J. Winefordner,et al.  Trace determination of nitrogen-containing drugs by surface enhanced Raman scattering spectrometry on silver colloids. , 1987, Analytical chemistry.

[17]  T. Vo-Dinh,et al.  Investigation of Experimental Parameters for Surface-Enhanced Raman Scattering (SERS) Using Silver-Coated Microsphere Substrates , 1987 .

[18]  M. Albrecht,et al.  Plasma resonance enhancement of Raman scattering by pyridine adsorbed on silver or gold sol particles of size comparable to the excitation wavelength , 1979 .

[19]  D. E. Willis,et al.  Calculation of Flame Ionization Detector Relative Response Factors Using the Effective Carbon Number Concept , 1985 .

[20]  H. Tong,et al.  Flame ionization detector response factors for compound classes in quantitative analysis of complex organic mixtures , 1984 .

[21]  R. G. Ackman.  Fundamental Groups in the Response of Flame Ionization Detectors to Oxygenated Aliphatic Hydrocarbons , 1964 .

[22]  B. A. Schaefer.  The calculation of ion currents in hydrocarbon flames , 1984 .

[23]  A. Nicholson,et al.  Ion Formation in the Flame Ionization Detector , 1980 .

[24]  R. E. Laramy,et al.  Flame Response in the Quantitative Determination of High Molecular Weight Paraffins and Alcohols by Gas Chromatography. , 1963 .

[25]  M. Kerker,et al.  Effect of aggregates on extinction and surface-enhanced Raman scattering spectra of colloidal silver , 1984 .

[26]  J. Winefordner,et al.  Surface Enhanced Raman Spectrometry on Silver Hydrosols Studied by Flow Injection Analysis , 1987 .

[27]  T. Mernagh,et al.  Auger electron spectroscopic evidence for laser damage on silver electrodes exhibiting surface-enhanced Raman scattering , 1983 .

[28]  S. Higuchi,et al.  Determination of small amounts of some sulfonamide drugs by resonance raman spectrometry , 1980 .

[29]  T. Vo‐Dinh,et al.  Surface-enhanced Raman spectrometry of organophosphorus chemical agents. , 1987, Analytical chemistry.

[30]  Tuan Vo-Dinh,et al.  Detection of nitro-polynuclear aromatic compounds by surface-enhanced Raman spectrometry , 1986 .