论文信息 - A Highly Efficient Synthesis of Telaprevir by Strategic Use of Biocatalysis and Multicomponent Reactions.

A Highly Efficient Synthesis of Telaprevir by Strategic Use of Biocatalysis and Multicomponent Reactions.

A short and efficient synthesis of the important drug candidate telaprevir (IX), featuring a biocatalytic desymmetrization and two multicomponent reactions as the key steps is presented.

[1] N. Turner,et al. A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions. , 2010, Chemical communications.